3D printing of solid oral dosage forms: numerous challenges with unique opportunities

Journal article

Hassanin, H. 2020. 3D printing of solid oral dosage forms: numerous challenges with unique opportunities. Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.xphs.2020.08.029
AuthorsHassanin, H.

Since the FDA approval of Spritam, there has been a growing interest in the application of 3D printing in pharmaceutical science. 3D printing is a method of manufacturing involving the layer-by-layer deposition of materials to create a final product according to a digital model. There are various techniques used to achieve this method of printing including the SLS, SLA, FDM, SSE and PB-inkjet printing. In biomanufacturing, bone and tissue engineering involving 3D printing to create scaffolds, while in pharmaceutics, 3D printing was applied in drug development, and the fabrication of drug delivery devices. This paper aims to review the use of some 3D printing techniques in the fabrication of oral solid dosage forms. FDM , SLA SLS , and PB-Inkjet printing processes were found suitable for the fabrication of oral solid dosage forms, though a great deal of the available research was focused on fused deposition modelling due to its availability and flexibility. Process parameters as well as strategies to control the characteristics of printed dosage forms are analysed and discussed. The review also presents the advantages and possible limitations of 3D printing of medicines.

Keywords3D printing; Pharmaceutical science
JournalJournal of Pharmaceutical Sciences
Digital Object Identifier (DOI)https://doi.org/10.1016/j.xphs.2020.08.029
Official URLhttps://doi.org/10.1016/j.xphs.2020.08.029
Publication dates
Online23 Sep 2020
Publication process dates
Accepted29 Aug 2020
Deposited03 Sep 2020
Accepted author manuscript
File Access Level
Output statusPublished

(1) Essa K, Hassanin H, Attallah MM, Adkins NJ, Musker AJ, Roberts GT, et al. Development and testing of an additively manufactured monolithic catalyst bed for HTP thruster applications. Applied Catalysis A: General 2017;542:125-135.
(2) Galatas A, Hassanin H, Zweiri Y, Seneviratne L. Additive Manufactured Sandwich Composite/ABS Parts for Unmanned Aerial Vehicle Applications. Polymers 2018;10(11).
(3) Sabouri A, Yetisen AK, Sadigzade R, Hassanin H, Essa K, Butt H. Three-Dimensional Microstructured Lattices for Oil Sensing. Energy and Fuels 2017;31(3):2524-2529.
(4) Mohammed A, Elshaer A, Sareh P, Elsayed M, Hassanin H. Additive Manufacturing Technologies for Drug Delivery Applications. Int J Pharm 2020;580.
(5) Zhang B, Gao L, Ma L, Luo Y, Yang H, Cui Z. 3D Bioprinting: A Novel Avenue for Manufacturing Tissues and Organs. Engineering 2019;5(4):777-794.
(6) Hassanin H, Finet L, Cox SC, Jamshidi P, Grover LM, Shepherd DET, et al. Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channels. Additive Manufacturing 2018;20:144-155.
(7) Fina F, Goyanes A, Madla CM, Awad A, Trenfield SJ, Kuek JM, et al. 3D printing of drug-loaded gyroid lattices using selective laser sintering. Int J Pharm 2018;547(1-2):44-52.
(8) Goyanes A, Fina F, Martorana A, Sedough D, Gaisford S, Basit AW. Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing. Int J Pharm 2017;527(1-2):21-30.
(9) Fina F, Madla CM, Goyanes A, Zhang J, Gaisford S, Basit AW. Fabricating 3D printed orally disintegrating printlets using selective laser sintering. Int J Pharm 2018;541(1-2):101-107.
(10) Khaled SA, Burley JC, Alexander MR, Roberts CJ. Desktop 3D printing of controlled release pharmaceutical bilayer tablets. International Journal of Pharmaceutics 2014;461(1):105-111.
(11) Liang K, Brambilla D, Leroux J. Is 3D Printing of Pharmaceuticals a Disruptor or Enabler? Advanced materials (Deerfield Beach, Fla.) 2019;31(5):e1805680.
(12) Klippstein H, Hassanin H, Alejandro, Diaz De Cerio Sanchez, Zweiri Y, Seneviratne L. Additive Manufacturing of Porous Structures for Unmanned Aerial Vehicles Applications. Adv Eng Mater 2018;20(9):1800290.
(13) Moritz T, Maleksaeedi S. 4 - Additive manufacturing of ceramic components. In: Zhang J, Jung Y, editors. Additive Manufacturing: Butterworth-Heinemann; 2018. p. 105-161.
(14) Qiu C, Adkins NJE, Hassanin H, Attallah MM, Essa K. In-situ shelling via selective laser melting: Modelling and microstructural characterisation. Mater Des 2015;87:845-853.
(15) Hassanin H, Essa K, Qiu C, Abdelhafeez AM, Adkins NJE, Attallah MM. Net-shape manufacturing using hybrid selective laser melting/hot isostatic pressing. Rapid Prototyping Journal 2017;23(4):720-726.
(16) El-Sayed M, Hassanin H, Essa K. Bifilm defects and porosity in Al cast alloys. Int J Adv Manuf Technol 2016;86(5-8):1173-1179.
(17) Hassanin H, Alkendi Y, Elsayed M, Essa K, Zweiri Y. Controlling the Properties of Additively Manufactured Cellular Structures Using Machine Learning Approaches. Advanced Engineering Materials 2020;22(3):n/a.
(18) Essa K, Khan R, Hassanin H, Attallah M, Reed R. An iterative approach of hot isostatic pressing tooling design for net-shape IN718 superalloy parts. Int J Adv Manuf Technol 2016;83(9-12):1835-1845.
(19) Kam D, Layani M, BarkaiMinerbi S, Orbaum D, Abrahami BenHarush S, Shoseyov O, et al. Additive Manufacturing of 3D Structures Composed of Wood Materials. Adv Mater Technol 2019;4(9):1900158.
(20) Melchels FPW, Domingos MAN, Klein TJ, Malda J, Bartolo PJ, Hutmacher DW. Additive manufacturing of tissues and organs. Progress in Polymer Science 2012;37(8):1079-1104.
(21) Mohammed Maniruzzaman, Wiley-VCH. 3D and 4D Printing in Biomedical Applications: Process Engineering and Additive Manufacturing. ; 2019.
(22) Al-Hashimi N, Begg N, Alany RG, Hassanin H, Elshaer A. Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles. Pharmaceutics 2018;10(4).
(23) Brenan CJH. 3-D Printed Pills: A New Age for Drug Delivery. IEEE pulse 2015;6(5):3.
(24) Pravin S, Sudhir A. Integration of 3D printing with dosage forms: A new perspective for modern healthcare. Biomedicine & Pharmacotherapy 2018;107:146-154.
(25) Kumar S. Selective laser sintering: A qualitative and objective approach. JOM 2003;55(10):43-47.
(26) Wang J, Goyanes A, Gaisford S, Basit AW. Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. Int J Pharm 2016;503(1-2):207-212.
(27) Skowyra J, Pietrzak K, Alhnan MA. Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. European Journal of Pharmaceutical Sciences 2015;68:11-17.
(28) Wu BM, Borland SW, Giordano RA, Cima LG, Sachs EM, Cima MJ. Solid free-form fabrication of drug delivery devices. J Controlled Release 1996;40(1-2):77-87.
(29) Franco A, Lanzetta M, Romoli L. Experimental analysis of selective laser sintering of polyamide powders: an energy perspective. Journal of Cleaner Production 2010;18(16):1722-1730.
(30) Alhnan M, Okwuosa T, Sadia M, Wan K, Ahmed W, Arafat B. Emergence of 3D Printed Dosage Forms: Opportunities and Challenges. Pharm Res 2016;33(8):1817-1832.
(31) Fina F, Goyanes A, Gaisford S, Basit AW. Selective laser sintering (SLS) 3D printing of medicines. Int J Pharm 2017;529(1-2):285-293.
(32) Mazzoli A. Selective laser sintering in biomedical engineering. Medical and Biological Engineering and Computing 2012;51(3):1-12.
(33) Dickens E.D., Lin L.B., Taylor G.A., Magistro A.J. and Ng H. Sinterable Semi-Crystalline Powder and Near Fully Dense Article Formed Therewith . 1994 August 30,.
(34) Kruth J-, Levy G, Klocke F, Childs THC. Consolidation phenomena in laser and powder-bed based layered manufacturing. CIRP Ann Manuf Technol 2007;56(2):730-759.
(35) Drummer D, Rietzel D, Kühnlein F. Development of a characterization approach for the sintering behavior of new thermoplastics for selective laser sintering. Physics Procedia 2010;5:533-542.
(36) Leong K, Chua C, Gui W, Verani W. Building Porous Biopolymeric Microstructures for Controlled Drug Delivery Devices Using Selective Laser Sintering. Int J Adv Manuf Technol 2006;31(5):483-489.
(37) Chia HN, Wu BM. Recent advances in 3D printing of biomaterials. Journal of biological engineering 2015;9(1):4.
(38) Norman J, Madurawe RD, Moore CMV, Khan MA, Khairuzzaman A. A new chapter in pharmaceutical manufacturing: 3D-printed drug products. Adv Drug Deliv Rev 2017;108:39-50.
(39) F.S. Iliescu. A double softlithography method for processing of noa63 microneedles arrays. UPB Scientific Bulletin, Series B: Chemistry and Materials Science 2017;79(2):121-132.
(40) Hassanin H, Jiang K. Multiple replication of thick PDMS micropatterns using surfactants as release agents. Microelectronic Engineering 2011;88(11):3275-3277.
(41) Zhu Z, Hassanin H, Jiang K. A soft moulding process for manufacture of net-shape ceramic microcomponents. Int J Adv Manuf Technol 2010;47(1):147-152.
(42) Hassanin H, Jiang K. Optimized process for the fabrication of zirconia micro parts. Microelectronic Engineering 2010;87(5):1617-1619.
(43) Hassanin H, Jiang K. Fabrication and characterization of stabilised zirconia micro parts via slip casting and soft moulding. Scr Mater 2013;69(6):433-436.
(44) Essa K, Modica F, Imbaby M, El-Sayed M, ElShaer A, Jiang K, et al. Manufacturing of metallic micro-components using hybrid soft lithography and micro-electrical discharge machining. Int J Adv Manuf Technol 2017;91(1-4):445-452.
(45) Hassanin H, Jiang K. Fabrication of Al 2 O 3 /SiC Composite Microcomponents using Non‐aqueous Suspension. Advanced Engineering Materials 2009;11(1):101-105.
(46) Hassanin H, Jiang K. Alumina composite suspension preparation for softlithography microfabrication. Microelectronic Engineering 2009;86(4):929-932.
(47) Hassanin H, Jiang K. Functionally graded microceramic components. Microelectronic Engineering 2010;87(5):1610-1613.
(48) Hassanin H, Jiang K. Net shape manufacturing of ceramic micro parts with tailored graded layers. J Micromech Microengineering 2013;24(1):015018.
(49) Martinez PR, Goyanes A, Basit AW, Gaisford S. Fabrication of drug-loaded hydrogels with stereolithographic 3D printing. Int J Pharm 2017;532(1):313-317.
(50) Cavallo A, Madaghiele M, Masullo U, Lionetto MG, Sannino A. Photo‐crosslinked poly(ethylene glycol) diacrylate (PEGDA) hydrogels from low molecular weight prepolymer: Swelling and permeation studies. J Appl Polym Sci 2017;134(2):n/a.
(51) Vehse M, Petersen S, Sternberg K, Schmitz K, Seitz H. Drug Delivery From Poly(ethylene glycol) Diacrylate Scaffolds Produced by DLC Based Micro‐Stereolithography. Macromolecular Symposia 2014;346(1):43-47.
(52) Gittard SD, Narayan RJ. Laser direct writing of micro- and nano-scale medical devices. Expert Review of Medical Devices 2010;7(3):343-356.
(53) Goole J, Amighi K. 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems. International Journal of Pharmaceutics 2016;499(1):376-394.
(54) Farkas B, Dante S, Brandi F. Photoinitiator-free 3D scaffolds fabricated by excimer laser photocuring. Nanotechnology 2016;28(3):034001.
(55) Applegate MB, Partlow BP, Coburn J, Marelli B, Pirie C, Pineda R, et al. Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses. Adv Mater 2016;28(12):2417-2420.
(56) Gonçalves F,A.M.M., Costa C, Fabela IGP, Farinha D, Faneca H, Simões P,N., et al. 3D printing of new biobased unsaturated polyesters by microstereo-thermal-lithography. Biofabrication 2014;6(3):035024.
(57) Applegate MB, Partlow BP, Coburn J, Marelli B, Pirie C, Pineda R, et al. Silk Fibroin: Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses (Adv. Mater. 12/2016. Adv Mater 2016;28(12):2464.
(58) Miao S, Zhu W, Castro NJ, Nowicki M, Zhou X, Cui H, et al. 4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate. Sci Rep 2016;6(1):27226.
(59) Martinez PR, Goyanes A, Basit AW, Gaisford S. Influence of Geometry on the Drug Release Profiles of Stereolithographic (SLA) 3D-Printed Tablets. AAPS PharmSciTech 2018;19(8):3355.
(60) Robles-Martinez P, Xu X, Trenfield SJ, Awad A, Goyanes A, Telford R, et al. 3D printing of a multi-layered polypill containing six drugs using a novel stereolithographic method. Pharmaceutics 2019;11(6).
(61) Xu X, Robles-Martinez P, Madla CM, Joubert F, Goyanes A, Basit AW, et al. Stereolithography (SLA) 3D printing of an antihypertensive polyprintlet: Case study of an unexpected photopolymer-drug reaction. Additive Manufacturing 2020;33:101071.
(62) Tan DK, Maniruzzaman M, Nokhodchi A. Advanced Pharmaceutical Applications of Hot-Melt Extrusion Coupled with Fused Deposition Modelling (FDM) 3D Printing for Personalised Drug Delivery. Pharmaceutics 2018;10(4).
(63) Kempin W, Domsta V, Grathoff G, Brecht I, Semmling B, Tillmann S, et al. Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug. Pharm Res 2018;35(6):1-12.
(64) Goyanes A, Buanz ABM, Hatton GB, Gaisford S, Basit AW. 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. European Journal of Pharmaceutics and Biopharmaceutics 2015;89:157-162.
(65) Smith DM, Kapoor Y, Klinzing GR, Procopio AT. Pharmaceutical 3D printing: Design and qualification of a single step print and fill capsule. Int J Pharm 2018;544(1):21-30.
(66) Goyanes A, Robles Martinez P, Buanz A, Basit AW, Gaisford S. Effect of geometry on drug release from 3D printed tablets. Int J Pharm 2015;494(2):657-663.
(67) Goyanes A, Wang J, Buanz A, Martínez-Pacheco R, Telford R, Gaisford S, et al. 3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics. Molecular pharmaceutics 2015;12(11):4077-4084.
(68) Holländer J, Genina N, Jukarainen H, Khajeheian M, Rosling A, Mäkilä E, et al. Three-Dimensional Printed PCL-Based Implantable Prototypes of Medical Devices for Controlled Drug Delivery. J Pharm Sci 2016;105(9):2665-2676.
(69) Gioumouxouzis CI, Baklavaridis A, Katsamenis OL, Markopoulou CK, Bouropoulos N, Tzetzis D, et al. A 3D printed bilayer oral solid dosage form combining metformin for prolonged and glimepiride for immediate drug delivery. European Journal of Pharmaceutical Sciences 2018;120:40-52.
(70) Farah S, Anderson DG, Langer R. Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review. Advanced Drug Delivery Reviews 2016;107:367-392.
(71) Eda HB, Yildirim Erbil H. Surface Modification of 3D Printed PLA Objects by Fused Deposition Modeling: A Review. Colloids and Interfaces 2019;3(2):43.
(72) Garlotta D. A literature review of poly(lactic acid). Journal of Polymers and the Environment 2001;9(2):63-84.
(73) Tokiwa Y, Calabia B. Biodegradability and biodegradation of poly(lactide). Appl Microbiol Biotechnol 2006;72(2):244-251.
(74) Demerlis CC, Schoneker DR. Review of the oral toxicity of polyvinyl alcohol (PVA). Food and Chemical Toxicology 2003;41(3):319-326.
(75) Gaaz T, Sulong AB, Akhtar M, Kadhum A, Mohamad AB, Al-Amiery AA. Properties and Applications of Polyvinyl Alcohol, Halloysite Nanotubes and Their Nanocomposites. Molecules 2015;20(12):22833-22847.
(76) MatterHackers. How To Succeed When 3D Printing With PVA Support Material. 2017; Available at: https://www.matterhackers.com/news/how-to-succeed-when-3d-printing-w... Accessed March 2, 2020.
(77) Pietrzak K, Isreb A, Alhnan MA. A flexible-dose dispenser for immediate and extended release 3D printed tablets. European Journal of Pharmaceutics and Biopharmaceutics 2015;96:380-387.
(78) Melocchi A, Parietti F, Maroni A, Foppoli A, Gazzaniga A, Zema L. Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by fused deposition modeling. Int J Pharm 2016;509(1-2):255-263.
(79) Alhijjaj M, Belton P, Qi S. An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing. European Journal of Pharmaceutics and Biopharmaceutics 2016;108:111-125.
(80) Zhang J, Feng X, Patil H, Tiwari RV, Repka MA. Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets. Int J Pharm 2017;519(1-2):186-197.
(81) Jamróz W, Szafraniec J, Kurek M, Jachowicz R. 3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges. Pharm Res 2018;35(9):1-22.
(82) Goyanes A, Buanz ABM, Basit AW, Gaisford S. Fused-filament 3D printing (3DP) for fabrication of tablets. Int J Pharm 2014;476(1-2):88-92.
(83) Goyanes A, Chang H, Sedough D, Hatton GB, Wang J, Buanz A, et al. Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing. Int J Pharm 2015;496(2):414-420.
(84) Okwuosa TC, Stefaniak D, Arafat B, Isreb A, Wan K, Alhnan MA. A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets. Pharm Res 2016;33(11):2704-2712.
(85) Goyanes A, Kobayashi M, Martínez-Pacheco R, Gaisford S, Basit AW. Fused-filament 3D printing of drug products: Microstructure analysis and drug release characteristics of PVA-based caplets. Int J Pharm 2016;514(1):290-295.
(86) Sadia M, Sośnicka A, Arafat B, Isreb A, Ahmed W, Kelarakis A, et al. Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets. Int J Pharm 2016;513(1-2):659-668.
(87) Nasereddin J, Wellner N, Alhijjaj M, Belton P, Qi S. Development of a Simple Mechanical Screening Method for Predicting the Feedability of a Pharmaceutical FDM 3D Printing Filament. Pharm Res 2018;35(8):1-13.
(88) Chai X, Chai H, Wang X, Yang J, Li J, Zhao Y, et al. Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone. Sci Rep 2017;7(1):2829.
(89) GBI Research. Oral Drug Delivery Market Report. 2012; Available at: https://www.contractpharma.com/issues/2012-06/view_features/oral-dru... Accessed February 14, 2020.
(90) Sadia M, Arafat B, Ahmed W, Forbes RT, Alhnan MA. Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets. J Controlled Release 2018;269:355-363.
(91) Scoutaris N, Ross S, Douroumis D. Current Trends on Medical and Pharmaceutical Applications of Inkjet Printing Technology. Pharm Res 2016;33(8):1799-1816.
(92) Derby B. Additive Manufacture of Ceramics Components by Inkjet Printing. Engineering 2015;1(1):113-123.
(93) Scoutaris N, Alexander MR, Gellert PR, Roberts CJ. Inkjet printing as a novel medicine formulation technique. J Controlled Release 2011;156(2):179-185.
(94) Rose D. Microdispensing technologies in drug discovery. Drug Discov Today 1999;4(9):411-419.
(95) Gbureck U, Hölzel T, Doillon C , Müller F , Barralet J . Direct Printing of Bioceramic Implants with Spatially Localized Angiogenic Factors. Adv Mater 2007;19(6):795-800.
(96) Arrabito G, Pignataro B. Inkjet printing methodologies for drug screening. Anal Chem 2010;82(8):3104-3107.
(97) Walter G, Büssow K, Cahill D, Lueking A, Lehrach H. Protein arrays for gene expression and molecular interaction screening. Curr Opin Microbiol 2000;3(3):298-302.
(98) Boehm RD, Miller PR, Daniels J, Stafslien S, Narayan RJ. Inkjet printing for pharmaceutical applications. Materials Today 2014;17(5):247-252.
(99) Kulkarni RB, Manners C, inventors. 3D Systems, Inc. (Valencia, CA), assignee. Rapid prototyping method and apparatus with simplified build preparation for production of three dimensional objects. . 2000 December 12,.
(100) WIGAND J, Theodore, WINEY, Calvin, McCoy, III, ARANKA M, inventors. SOLIDSCAPE INC, assignee. Method and apparatus for fabricating three dimensional models. WIPO (PCT) patent WO 2007/016469 A2. 2007 February 8.
(101) Sachs, Emanuel M, Haggerty, John S, Cima, Michael J, et al, inventors. Massachusetts Institute of Technology, assignee. Three-dimensional printing techniques. United States patent 5,204,055. 1993 Apr. 20,.
(102) Katstra WE, Palazzolo RD, Rowe CW, Giritlioglu B, Teung P, Cima MJ. Oral dosage forms fabricated by Three Dimensional Printingâ„¢. Journal of Controlled Release 2000;66(1):1-9.
(103) Rowe CW, Katstra WE, Palazzolo RD, Giritlioglu B, Teung P, Cima MJ. Multimechanism oral dosage forms fabricated by three dimensional printing™. J Controlled Release 2000;66(1):11-17.
(104) Yu D, Branford-White C, Yang Y, Zhu L, Welbeck EW, Yang X. A novel fast disintegrating tablet fabricated by three-dimensional printing. Drug Dev Ind Pharm 2009;35(12):1530-1536.
(105) Clark EA, Alexander MR, Irvine DJ, Roberts CJ, Wallace MJ, Sharpe S, et al. 3D printing of tablets using inkjet with UV photoinitiation. Int J Pharm 2017;529(1-2):523-530.
(106) Khaled SA, Burley JC, Alexander MR, Yang J, Roberts CJ. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. J Controlled Release 2015;217:308-314.
(107) Tagami T, Fukushige K, Ogawa E, Hayashi N, Ozeki T. 3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets. Biological and Pharmaceutical Bulletin 2017;40(3):357-364.
(108) Melocchi A, Uboldi M, Maroni A, Foppoli A, Palugan L, Zema L, et al. 3D printing by fused deposition modeling of single- and multi-compartment hollow systems for oral delivery – A review. International Journal of Pharmaceutics 2020;579:119155.
(109) Huanbutta K, Sangnim T. Design and development of zero-order drug release gastroretentive floating tablets fabricated by 3D printing technology. Journal of Drug Delivery Science and Technology 2019;52:831-837.
(110) Redekop WK, Mladsi D. The Faces of Personalized Medicine: A Framework for Understanding Its Meaning and Scope. Value in Health 2013;16(6):S4-S9.
(111) Rollason V, Vogt N. Reduction of Polypharmacy in the Elderly. Drugs Aging 2003;20(11):817-832.
(112) Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opinion on Drug Safety 2014;13(1):57-65.
(113) Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. The American Journal of Geriatric Pharmacotherapy 2007;5(4):345-351.
(114) Colley CA, Lucas LM. Polypharmacy: the cure becomes the disease. Journal of general internal medicine 1993;8(5):278-283.
(115) Vik SA, Maxwell CJ, Hogan DB. Measurement, correlates, and health outcomes of medication adherence among seniors. Ann Pharmacother 2004;38(2):303-312.
(116) Lee VW, Pang KK, Hui KC, Kwok JC, Leung SL, Yu DSF, et al. Medication adherence: Is it a hidden drug-related problem in hidden elderly? Geriatrics and Gerontology International 2013;13(4).
(117) Richard Matthews. Proposed new regulations for 3D printed medical devices must go further. 2018; Available at: https://theconversation.com/proposed-new-regulations-for-3d-printed-... Accessed February 14, 2020.
(118) Drues Michael. Printing medical devices at home is just the beginning: Part II. 2014; Available at: https://www.healthcarepackaging.com/machinery-materials/package-desi... Accessed February 14., 2020.
(119) Trenfield SJ, Goyanes A, Telford R, Wilsdon D, Rowland M, Gaisford S, et al. 3D printed drug products: Non-destructive dose verification using a rapid point-and-shoot approach. International Journal of Pharmaceutics 2018;549(1):283-292.
(120) Vakili H, Kolakovic R, Genina N, Marmion M, Salo H, Ihalainen P, et al. Hyperspectral imaging in quality control of inkjet printed personalised dosage forms. International Journal of Pharmaceutics 2015;483(1):244-249.

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El-Sayed, M.A., Essa, K., Ghazy, M. and Hassanin, H. 2020. Design optimisation of additively manufactured titanium lattice structures for biomedical implants. The International Journal of Advanced Manufacturing Technology. https://doi.org/10.1007/s00170-020-05982-8
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Hassanin, H., Abena, A., Elsayed, M.A. and Essa, K. 2020. 4D Printing of NiTi auxetic structure with improved ballistic performance. Micromachines. 11 (8), p. 745. https://doi.org/doi.org/10.3390/mi11080745