Fabrication and characterization of oxygen-generating polylactic acid/calcium peroxide composite filaments for bone scaffolds

Journal article

Mohammed, A., Saeed, A., Elshaer, A., Melaibari, A., Memić, A., Hassanin, H. and Essa, K. 2023. Fabrication and characterization of oxygen-generating polylactic acid/calcium peroxide composite filaments for bone scaffolds. Pharmaceuticals. 16 (4), p. 627. https://doi.org/10.3390/ph16040627
AuthorsMohammed, A., Saeed, A., Elshaer, A., Melaibari, A., Memić, A., Hassanin, H. and Essa, K.
AbstractThe latest advancements in bone scaffold technology have introduced novel biomaterials that have the ability to generate oxygen when implanted, improving cell viability and tissue maturation. In this paper, we present a new oxygen-generating polylactic acid (PLA)/calcium peroxide (CPO) composite filament that can be used in 3D printing scaffolds. The composite material was prepared using a wet solution mixing method, followed by drying and hot melting extrusion. The concentration of calcium peroxide in the composite varied from 0% to 9%. The prepared filaments were characterized in terms of the presence of calcium peroxide, the generated oxygen release, porosity, and antibacterial activities. Data obtained from scanning electron microscopy and X-ray diffraction showed that the calcium peroxide remained stable in the composite. The maximum calcium and oxygen release was observed in filaments with a 6% calcium peroxide content. In addition, bacterial inhibition was achieved in samples with a calcium peroxide content of 6% or higher. These results indicate that an optimized PLA filament with a 6% calcium peroxide content holds great promise for improving bone generation through bone cell oxygenation and resistance to bacterial infections.
Keywords3D priting filament ; Bone scaffold; Tissue engineering ; Oxygen releases; Poly lactic acid; Calcium
Year2023
JournalPharmaceuticals
Journal citation16 (4), p. 627
PublisherMDPI
ISSN1424-8247
Digital Object Identifier (DOI)https://doi.org/10.3390/ph16040627
Official URLhttps://www.mdpi.com/1424-8247/16/4/627
Publication dates
Online20 Apr 2023
Publication process dates
Accepted14 Apr 2023
Deposited27 Jul 2023
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