Fabrication and characterization of oxygen-generating polylactic acid/calcium peroxide composite filaments for bone scaffolds

Journal article


Mohammed, A., Saeed, A., Elshaer, A., Melaibari, A., Memić, A., Hassanin, H. and Essa, K. 2023. Fabrication and characterization of oxygen-generating polylactic acid/calcium peroxide composite filaments for bone scaffolds. Pharmaceuticals. 16 (4), p. 627. https://doi.org/10.3390/ph16040627
AuthorsMohammed, A., Saeed, A., Elshaer, A., Melaibari, A., Memić, A., Hassanin, H. and Essa, K.
AbstractThe latest advancements in bone scaffold technology have introduced novel biomaterials that have the ability to generate oxygen when implanted, improving cell viability and tissue maturation. In this paper, we present a new oxygen-generating polylactic acid (PLA)/calcium peroxide (CPO) composite filament that can be used in 3D printing scaffolds. The composite material was prepared using a wet solution mixing method, followed by drying and hot melting extrusion. The concentration of calcium peroxide in the composite varied from 0% to 9%. The prepared filaments were characterized in terms of the presence of calcium peroxide, the generated oxygen release, porosity, and antibacterial activities. Data obtained from scanning electron microscopy and X-ray diffraction showed that the calcium peroxide remained stable in the composite. The maximum calcium and oxygen release was observed in filaments with a 6% calcium peroxide content. In addition, bacterial inhibition was achieved in samples with a calcium peroxide content of 6% or higher. These results indicate that an optimized PLA filament with a 6% calcium peroxide content holds great promise for improving bone generation through bone cell oxygenation and resistance to bacterial infections.
Keywords3D priting filament ; Bone scaffold; Tissue engineering ; Oxygen releases; Poly lactic acid; Calcium
Year2023
JournalPharmaceuticals
Journal citation16 (4), p. 627
PublisherMDPI
ISSN1424-8247
Digital Object Identifier (DOI)https://doi.org/10.3390/ph16040627
Official URLhttps://www.mdpi.com/1424-8247/16/4/627
Publication dates
Online20 Apr 2023
Publication process dates
Accepted14 Apr 2023
Deposited27 Jul 2023
Publisher's version
License
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/947zq/fabrication-and-characterization-of-oxygen-generating-polylactic-acid-calcium-peroxide-composite-filaments-for-bone-scaffolds

Download files


Publisher's version
  • 17
    total views
  • 3
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Contactless single point incremental forming: Experimental and numerical simulation
Almadani, M., Guner, A., Hassanin, H., De Lisi, Michele. and Essa, K. 2023. Contactless single point incremental forming: Experimental and numerical simulation. The International Journal of Advanced Manufacturing Technology. https://doi.org/10.1007/s00170-023-12401-1
Hot-air contactless single-point incremental forming
Almadani, M., Guner, A., Hassanin, H. and Essa, K. 2023. Hot-air contactless single-point incremental forming. Journal of Manufacturing and Materials Processing. 7 (5), p. 179. https://doi.org/10.3390/jmmp7050179
Optimising surface roughness and density in titanium fabrication via laser powder bed fusion
Hassanin, H., El-Sayed, M., Ahmadein, M., A. Alsaleh, N., Ataya, S., Ahmed, M. and Essa, K. 2023. Optimising surface roughness and density in titanium fabrication via laser powder bed fusion. Micromachines. 14 (8), p. 1642. https://doi.org/10.3390/mi14081642
Hybrid finite element–smoothed particle hydrodynamics modelling for optimizing cutting parameters in CFRP composites
Abena, A., Ataya, S., Hassanin, H., El-Sayed, M., Ahmadein, M., A. Alsaleh, N., Ahmed, M. and Essa, K. 2023. Hybrid finite element–smoothed particle hydrodynamics modelling for optimizing cutting parameters in CFRP composites. Polymers. 15 (13), p. 2789. https://doi.org/10.3390/polym15132789
Embracing sustainable farming: Unleashing the circular economy potential of second-life EV batteries in agricultural applications
Al-Alawi, M., Cugley, J. and Hassanin, H. 2023. Embracing sustainable farming: Unleashing the circular economy potential of second-life EV batteries in agricultural applications.
Entrained defects and mechanical properties of aluminium castings
El-Sayed, M., Essa, K. and Hassanin, H. 2023. Entrained defects and mechanical properties of aluminium castings.
Review on engineering of bone scaffolds using conventional and additive manufacturing technologies
Mohammed, A., Jiménez, A., Bidare, P., Elshaer, A., Memić, A., Hassanin, H. and Essa, K. 2023. Review on engineering of bone scaffolds using conventional and additive manufacturing technologies. 3D Printing and Additive Manufacturing. https://doi.org/10.1089/3dp.2022.0360
Preparation of polylactic acid/calcium peroxide compo-site filaments for fused deposition modelling
Mohammed, A., Kovacev , N., Elshaer, A., Melaibari, A., Iqbal, J., Hassanin, H., Essa, K. and Memić, A. 2023. Preparation of polylactic acid/calcium peroxide compo-site filaments for fused deposition modelling. Polymers. 15 (9), p. 2229. https://doi.org/10.3390/polym15092229
Non-destructive disassembly of interference fit under wear conditions for sustainable remanufacturing
Yeung, H., Ataya, S., Hassanin, H., El-Sayed, M., Ahmadein, M., A. Alsaleh, N., Ahmed, M. and Essa, K. 2023. Non-destructive disassembly of interference fit under wear conditions for sustainable remanufacturing. Machines. 11 (5), p. 538. https://doi.org/10.3390/machines11050538
Using second-life batteries and solar power to help farms become energy efficient.
Al-Alawi, M., Cugley, J. and Hassanin, H. 2023. Using second-life batteries and solar power to help farms become energy efficient. Canterbury Christ Church University.
Chip formation and orthogonal cutting optimisation of unidirectional carbon fibre composites
Hassanin, H., Abena, A., Soo, L., Ataya, S., El-Sayed, M., Ahmadein, M., A. Alsaleh, N., Ahmed, M. and Essa, K. 2023. Chip formation and orthogonal cutting optimisation of unidirectional carbon fibre composites. Polymers. 15 (8), p. 1897. https://doi.org/10.3390/polym15081897
Fabrication and Optimisation of Ti-6Al-4V Lattice-Structured Total Shoulder Implants Using Laser Additive Manufacturing
Bittredge, Oliver, Hassanin, H., El-Sayed, M., Eldessouky, Hossam Mohamed, A. Alsaleh, N., Alrasheedi, Nashmi H., Essa, K. and Ahmadein, M. 2022. Fabrication and Optimisation of Ti-6Al-4V Lattice-Structured Total Shoulder Implants Using Laser Additive Manufacturing. Materials (Basel, Switzerland). 15 (9), p. e3095. https://doi.org/10.3390/ma15093095
Influence of Bifilm Defects Generated during Mould Filling on the Tensile Properties of Al−Si−Mg Cast Alloys
El-Sayed, M., Essa, K. and Hassanin, H. 2022. Influence of Bifilm Defects Generated during Mould Filling on the Tensile Properties of Al−Si−Mg Cast Alloys. Metals. 12 (1), p. e160. https://doi.org/10.3390/met12010160
Elastomer-based visuotactile sensor for normality of robotic manufacturing systems
Hassanin, H., Zaid, I., Halwani, M., Ayyad, A., Imam, A., Almaskari, F. and Zweiri, Y. 2022. Elastomer-based visuotactile sensor for normality of robotic manufacturing systems. Polymers. 14 (23), p. 5097. https://doi.org/10.3390/polym14235097
Techno-economic feasibility of retired electric-vehicle batteries repurpose/reuse in second-life applications: A systematic review
Hassanin, H., Al-Alawi, M. and Cugley, J. 2022. Techno-economic feasibility of retired electric-vehicle batteries repurpose/reuse in second-life applications: A systematic review. Energy and Climate Change. 3 (100086). https://doi.org/10.1016/j.egycc.2022.100086
Planning, operation, and design of market-based virtual power plant considering uncertainty
Hassanin, H., Ullah, Z., Arshad, Cugley, J. and Al-Alawi, M. 2022. Planning, operation, and design of market-based virtual power plant considering uncertainty. Energies. 19 (15), p. 7290. https://doi.org/10.3390/en15197290
The epistemic insight digest: Issue : Autumn 2022
Gordon, A., Shalet, D., Simpson, S., Hassanin, H., Lawson, F., Lawson, M., Litchfield, A., Thomas, C., Canetta, E., Manley, K. and Choong, C. Shalet, D. (ed.) 2022. The epistemic insight digest: Issue : Autumn 2022. Canterbury Canterbury Christ Church University.
Modeling, optimization, and analysis of a virtual power plant demand response mechanism for the internal electricity market considering the uncertainty of renewable energy sources
Ullah, Z., Arshad and Hassanin, H. 2022. Modeling, optimization, and analysis of a virtual power plant demand response mechanism for the internal electricity market considering the uncertainty of renewable energy sources. Energies. 15 (14), p. 5296. https://doi.org/doi.org/10.3390/en15145296
Interdisciplinary engineering education - essential for the 21st century
Gordon, A., Simpson, S. and Hassanin, H. 2022. Interdisciplinary engineering education - essential for the 21st century.
Multipoint forming using hole-type rubber punch
Hassanin, H., Tolipov, A., El-Sayed, M., Eldessouky, H., A. Alsaleh, N., Alfozan, A., Essa, K. and Ahmadein, M. 2022. Multipoint forming using hole-type rubber punch. Metals. 12 (3), p. 491. https://doi.org/10.3390/met12030491
Multistage Tool Path Optimisation of Single-Point Incremental Forming Process
Yan, Zhou, Hassanin, H., El-Sayed, M., Eldessouky, Hossam Mohamed, Djuansjah, Joy Rizki Pangestu, A. Alsaleh, N., Essa, K. and Ahmadein, M. 2021. Multistage Tool Path Optimisation of Single-Point Incremental Forming Process. Materials (Basel, Switzerland). 14 (22), p. e6794. https://doi.org/10.3390/ma14226794
Effect of runner thickness and hydrogen content on the mechanical properties of A356 alloy castings
El-Sayed, M., Essa, K. and Hassanin, H. 2021. Effect of runner thickness and hydrogen content on the mechanical properties of A356 alloy castings . International Journal of Metalcasting. https://doi.org/10.1007/s40962-021-00753-x
Parts design and process optimization
Hassanin, Hany, Bidare, Prveen, Zweiri, Yahya and Essa, Khamis 2021. Parts design and process optimization. in: Salunkhe, S., Hussein, H. and Davim, J. (ed.) Applications of Artificial Intelligence in Additive Manufacturing USA IGI Global. pp. 25-49
Micro-additive manufacturing technologies of three-dimensional MEMS
Hassanin, H., Sheikholeslami, G., Pooya, S. and Ishaq, R. 2021. Micro-additive manufacturing technologies of three-dimensional MEMS . Advanced Engineering Materials. https://doi.org/10.1002/adem.202100422
Machine learning applied to the design and inspection of reinforced concrete bridges: Resilient methods and emerging applications
Fan , W., Chen, Y., Li, J., Sun, Y., Feng, F., Hassanin, H. and Sareh, P. 2021. Machine learning applied to the design and inspection of reinforced concrete bridges: Resilient methods and emerging applications. Structures. 33, pp. 3954-3963. https://doi.org/10.1016/j.istruc.2021.06.110
Porosity, cracks, and mechanical properties of additively manufactured tooling alloys: A review
Bidare, P., Jiménez, A., Hassanin, H. and Essa, K. 2021. Porosity, cracks, and mechanical properties of additively manufactured tooling alloys: A review. Advances in Manufacturing. https://doi.org/10.1007/s40436-021-00365-y
Laser powder bed fusion of Ti-6Al-2Sn-4Zr-6Mo alloy and properties prediction using deep learning approaches
Hassanin, H., Zweiri, Y., Finet, L., Essa, K., Qiu, C. and Attallah, M. 2021. Laser powder bed fusion of Ti-6Al-2Sn-4Zr-6Mo alloy and properties prediction using deep learning approaches. Materials. 14 (8), p. 2056. https://doi.org/10.3390/ma14082056
3DP printing of oral solid formulations: a systematic review
Brambilla, C., Okafor-Muo, O., Hassanin, H. and ElShaer, A. 2021. 3DP printing of oral solid formulations: a systematic review. Pharmaceutics. 13 (3), p. 358. https://doi.org/10.3390/pharmaceutics13030358
Powder-based laser hybrid additive manufacturing of metals: A review
Hassanin, H. 2021. Powder-based laser hybrid additive manufacturing of metals: A review. The International Journal of Advanced Manufacturing Technology.
Micro-fabrication of ceramics: additive manufacturing and conventional technologies
Hassanin, H., Essa, K., Elshaer, A., Imbaby, M. and El-Sayed, T. E. 2021. Micro-fabrication of ceramics: additive manufacturing and conventional technologies. Journal of Advanced Ceramics. 10, pp. 1-27. https://doi.org/10.1007/s40145-020-0422-5
4D Printing of origami structures for minimally invasive surgeries using functional scaffold
Langford, T, Mohammed, A., Essa, K., Elshaer, A. and Hassanin, H. 2020. 4D Printing of origami structures for minimally invasive surgeries using functional scaffold. Applied Sciences. 11 (1), p. 332. https://doi.org/10.3390/app11010332
Reconfigurable multipoint forming using waffle-type elastic cushion and variable loading profile
Hassanin, H., Mohammed, M., Abdel-Wahab, A. and Essa, K 2020. Reconfigurable multipoint forming using waffle-type elastic cushion and variable loading profile. Materials.
3D printing of solid oral dosage forms: numerous challenges with unique opportunities
Hassanin, H. 2020. 3D printing of solid oral dosage forms: numerous challenges with unique opportunities. Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.xphs.2020.08.029
Design optimisation of additively manufactured titanium lattice structures for biomedical implants
El-Sayed, M.A., Essa, K., Ghazy, M. and Hassanin, H. 2020. Design optimisation of additively manufactured titanium lattice structures for biomedical implants. The International Journal of Advanced Manufacturing Technology. https://doi.org/10.1007/s00170-020-05982-8
4D Printing of NiTi auxetic structure with improved ballistic performance
Hassanin, H., Abena, A., Elsayed, M.A. and Essa, K. 2020. 4D Printing of NiTi auxetic structure with improved ballistic performance. Micromachines. 11 (8), p. 745. https://doi.org/doi.org/10.3390/mi11080745