Exploring the effectiveness of eHealth interventions in treating Post Intensive Care Syndrome (PICS) outcomes: a systematic review

Journal article

D'Oliveira, T., Shergill, S., Dikomitis, L., Lai Jie, D., Johnston, E. and Liu, Z. 2024. Exploring the effectiveness of eHealth interventions in treating Post Intensive Care Syndrome (PICS) outcomes: a systematic review. Critical Care.
AuthorsD'Oliveira, T., Shergill, S., Dikomitis, L., Lai Jie, D., Johnston, E. and Liu, Z.
Abstract

Background:
It remains unclear how to optimise critical care rehabilitation outcomes to reduce the constellation of long-term physical, psychological and cognitive impairments known as Post Intensive Care Syndrome (PICS). Possible reasons for poor recovery include access to care and delayed treatment. eHealth could potentially aid in increasing access and provide consistent care remotely. Our review aimed to evaluate the effectiveness of eHealth interventions on PICS outcomes.

Methods:
Studies reporting eHealth interventions targeting Post Intensive Care Syndrome outcomes, published in Medline, CINAHL, PsycINFO, Embase, and Scopus from 30th January 2010 to 12th February 2024, were included in the review. Study eligibility was assessed by two reviewers and any disagreements were discussed between them or resolved by a third reviewer. Study quality and risk of bias were assessed using the Mixed Method Appraisal Tool. Further to the identification of effective strategies, our review also aimed to clarify the timeline of recovery considered and the outcomes or domains targeted by the interventions.

Results:
Out of 3,673 articles screened, 13 studies were included in our review. Most studies were conducted in the early post discharge phase (i.e., < 3 months) and presented preliminary effectiveness of eHealth interventions on physical and psychological outcomes. Despite evidence suggesting an optimisation of rehabilitative effects when multiple domains are targeted in the intervention, research has yet to concurrently target all three domains of PICS. Though the interventions were described as feasible and acceptable in all studies, the lack of robust monitoring systems to track the PICS domain outcomes is indisputable.

Conclusion:
Our systematic review highlighted the promising contributions of eHealth with preliminary support for the feasibility and effectiveness of interventions in the early stages of post-critical care rehabilitation. However, it also highlights the fragmented approach to the concept of PICS. The 3 domains should be viewed as interrelated and not as distinct areas of recovery. Future research needs to investigate an integrative approach to these three domains, explore potential domain interrelationships, consider the challenges associated with large-scale eHealth implementation, and greater use of remote monitoring systems. Despite these challenges, eHealth is a critical solution in providing access, continuity, and sustainable care in the post-critical care setting.

KeywordsCritical care; Critical illness; Critical care rehabilitation; Post intensive care syndrome; eHealth; Digital health technologies
Year2024
JournalCritical Care
PublisherBioMed Central
ISSN1364-8535
1466-609X
Official URLhttps://ccforum.biomedcentral.com/articles/10.1186/s13054-024-05089-6
Publication dates
Online27 Sep 2024
Publication process dates
Accepted08 Sep 2024
Deposited11 Sep 2024
Accepted author manuscript
License
File Access Level
Open
Output statusPublished
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Agampodi, T., Nuwangi, H., Gunasekara, Sonali, Mallawaarachchi, Asitha, Price, Helen P, Dikomitis, Lisa and Agampodi, S. 2023. Safeguarding community-centred global health research during crises. BMJ Global Health. 8 (8), p. e013304. https://doi.org/10.1136/bmjgh-2023-013304
'We do not rush to the hospital for ordinary wounds (suḷu tuvāla)': A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka.
Gunasekara, Sonali Dinushika, Wickramasinghe, Nuwan Darshana, Agampodi, S., Fernando, Manoj Sanjeewa, Weerakoon, Kosala Gayan, Liyanage, Chandani, Dikomitis, Lisa and Agampodi, Thilini Chanchala 2023. 'We do not rush to the hospital for ordinary wounds (suḷu tuvāla)': A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka. PLoS Neglected Tropical Diseases. 17 (5), p. e0010939. https://doi.org/10.1371/journal.pntd.0010939
Do loneliness and social exclusion breed paranoia? An experience sampling investigation across the psychosis continuum.
Bell, Victoria, Velthorst, Eva, Almansa, Jorge, Myin-Germeys, Inez, Shergill, Sukhi and Fett, Anne-Kathrin 2023. Do loneliness and social exclusion breed paranoia? An experience sampling investigation across the psychosis continuum. Schizophrenia Research: Cognition. 33, p. 100282. https://doi.org/10.1016/j.scog.2023.100282
The functions of self‐harm in young people and their perspectives about future general practitioner‐led care: A qualitative study
Mughal, F., Chew‐Graham, Carolyn A., Babatunde, Opeyemi O., Saunders, Benjamin, Meki, Aula and Dikomitis, Lisa 2023. The functions of self‐harm in young people and their perspectives about future general practitioner‐led care: A qualitative study. Health Expectations. 26 (3), pp. 1180-1188. https://doi.org/10.1111/hex.13733
Automatic detection of cognitive impairment with virtual reality
Mannan, Farzana A, Porffy, Lilla A, Joyce, Dan W, Shergill, Sukhwinder S and Celiktutan, O. 2023. Automatic detection of cognitive impairment with virtual reality. Sensors. 23 (2), p. 1026. https://doi.org/10.3390/s23021026
Neuroimaging glutamatergic mechanisms differentiating antipsychotic treatment-response
Mouchlianitis, Elias D, Vanes, Lucy D, Tracy, Derek K, Fett, Anne-Katherin, Joyce, Daniel and Shergill, Sukhi S 2023. Neuroimaging glutamatergic mechanisms differentiating antipsychotic treatment-response. Scientific Reports. 13 (1), p. 8938. https://doi.org/10.1038/s41598-022-26702-0
Cognitive bias modification for paranoia (CBM-pa): a randomised controlled feasibility study in patients with distressing paranoid beliefs.
Yiend, Jenny, Lam, C., Schmidt, Nora, Crane, Bryony, Heslin, Margaret, Kabir, Thomas, McGuire, Philip, Meek, Christopher, Mouchlianitis, Elias, Peters, Emmanuelle, Stahl, Daniel, Trotta, Antonella and Shergill, Sukhwinder 2022. Cognitive bias modification for paranoia (CBM-pa): a randomised controlled feasibility study in patients with distressing paranoid beliefs. Psychological Medicine. https://doi.org/10.1017/S0033291722001520
Why care about integrated care? Part 3. Weighing sunlight: delivering integration in practice and measuring success
Tracy, D. K., Hanson, K., Underwood, B. R. and Shergill, S. 2022. Why care about integrated care? Part 3. Weighing sunlight: delivering integration in practice and measuring success. BJPsych Advances. 29 (1), pp. 31-40. https://doi.org/10.1192/bja.2022.26
Recommendations on patient-facing websites regarding diagnostic imaging for low back, knee, and shoulder pain: A scoping review
Andrew Cuff, Thomas Jesson, Gillian Yeowell, Lisa Dikomitis, Nadine E. Foster and Chris Littlewood 2022. Recommendations on patient-facing websites regarding diagnostic imaging for low back, knee, and shoulder pain: A scoping review. PEC Innovation. 1. https://doi.org/10.1016/j.pecinn.2022.100040
The experiences and needs of supporting individuals of young people who self-harm: A systematic review and thematic synthesis
Faraz Mughal, M. Isabela Troya, Lisa Dikomitis, Stephanie Tierney, Nadia Corp, Nicola Evans, Ellen Townsend and Carolyn A. Chew-Graham 2022. The experiences and needs of supporting individuals of young people who self-harm: A systematic review and thematic synthesis. eClinicalMedicine. 48, p. 101437. https://doi.org/10.1016/j.eclinm.2022.101437
Sickle cell disease in Bahia, Brazil: The social production of health policies and institutional neglect
Mota, C., Trad, L. and Dikomitis, L. 2022. Sickle cell disease in Bahia, Brazil: The social production of health policies and institutional neglect. Societies. 12 (4), p. 108. https://doi.org/10.3390/soc12040108
Update on the pathophysiology of cluster headache: Imaging and neuropeptide studies
Buture, A., Boland, J. W., Dikomitis, L. and Ahmed, F. 2022. Update on the pathophysiology of cluster headache: Imaging and neuropeptide studies. Journal of Pain Research. 12, pp. 269-281. https://doi.org/10.2147/JPR.S175312
The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin
Shergill, S., Rebekah Wigton, Derek K. Tracy, Tess M. Verneuil, Michaela Johns, Thomas White, Panayiota G. Michalopoulou, Bruno Averbeck and Sukhwinder Shergill 2022. The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin. Schizophrenia Research: Cognition. 27. https://doi.org/10.1016/j.scog.2021.100221
Stimulating learning: A functional MRI and behavioral investigation of the effects of transcranial direct current stimulation on stochastic learning in schizophrenia
Natasza D. Orlov, Syed Ali Muqtadir, Hooman Oroojeni, Bruno Averbeck, John Rothwell and Sukhi S. Shergill 2022. Stimulating learning: A functional MRI and behavioral investigation of the effects of transcranial direct current stimulation on stochastic learning in schizophrenia. Psychiatry Research. 317, p. 114908. https://doi.org/10.1016/j.psychres.2022.114908
Conceptualising and Teaching Biomedical Uncertainty to Medical Students: an Exploratory Qualitative Study
Eva Lukšaitė, Rosemary A. Fricker, Robert K. McKinley and Lisa Dikomitis 2022. Conceptualising and Teaching Biomedical Uncertainty to Medical Students: an Exploratory Qualitative Study. Medical Science Educator. 32, pp. 371-378. https://doi.org/10.1007/s40670-021-01481-x
A novel virtual reality assessment of functional cognition: Validation study
Lilla Alexandra Porffy, Mitul A Mehta, Joel Patchit, Celia Boussebaa, Jack Brett, Teresa D’Oliveira, Elias Mouchlianitis and Sukhi Shergill. 2022. A novel virtual reality assessment of functional cognition: Validation study. Journal of Medical Internet Research. 24 (1), p. e27641. https://doi.org/10.2196/27641
The potential of general practice to support young people who self-harm: a narrative review
Faraz Mughal, Lisa Dikomitis, Opeyemi O Babatunde and Carolyn A Chew-Graham 2022. The potential of general practice to support young people who self-harm: a narrative review. British Journal of General Practice Open (BJGP Open). 6 (1). https://doi.org/10.3399/BJGPO.2021.0159
Exploring the impact of the first wave of COVID-19 on social work practice: A qualitative study in England, UK
Tom Kingstone, Paul Campbell, Alina Andras, Karen Nixon, Christian Mallen, Lisa Dikomitis and The Q-COVID-19 Group 2022. Exploring the impact of the first wave of COVID-19 on social work practice: A qualitative study in England, UK. The British Journal of Social Work. 52 (4), pp. 2043-2062. https://doi.org/10.1093/bjsw/bcab166
How do people with knee osteoarthritis perceive and manage flares? A qualitative study
Parry, E., Dikomitis, L., Peat, G. and Chew-Graham, C. A. 2022. How do people with knee osteoarthritis perceive and manage flares? A qualitative study. British Journal of General Practice (BJGP). 6 (2), p. BJGPO.2021.0086. https://doi.org/10.3399/BJGPO.2021.0086
Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt - a sequential mixed-methods study designing an intervention bundle
Maatla Tshimologo, Kerry Allen, David Coyle, Sarah Damery, Lisa Dikomitis, James Fotheringham, Harry Hill, Mark Lambie, Louise Phillips-Darby, Ivonne Solis-Trapala, Iestyn Williams and Simon J Davies 2022. Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt - a sequential mixed-methods study designing an intervention bundle. BMJ Open. 12 (6).
Relaxation of the criteria for entry to the UK Clozapine Central Non-Rechallenge Database: a modelling study
Ebenezer Oloyede, Eromona Whiskey, Cecilia Casetta, Olubanke Dzahini, Danielle Dunnett, Shreyans Gandhi, Prof Fiona Gaughran, Prof Sukhi Shergill, Prof Philip McGuire, Prof James H MacCabe and Prof David Taylor 2022. Relaxation of the criteria for entry to the UK Clozapine Central Non-Rechallenge Database: a modelling study. The Lancet: Psychiatry. 9 (8), pp. 636-644. https://doi.org/10.1016/S2215-0366(22)00188-2
Experiences of newly diagnosed oral cancer patients during the first wave of the COVID-19 pandemic: A qualitative study from Pakistan
Khattak, M., Khattak, Saad Ishaq, Khan, Muslim, Khan, Z., Dikomitis, L., Ul-Haq, Z. and Saddki, N. 2022. Experiences of newly diagnosed oral cancer patients during the first wave of the COVID-19 pandemic: A qualitative study from Pakistan. International Journal of Environmental Research and Public Health. 19 (14), p. 8508. https://doi.org/1660-4601/19/14/8508
Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review
Brianne Wenning, Helen Price, Hasara Nuwangi, Kelemework Tafere Reda, Ben Walters, Reem Ehsanullah, Greice Viana, Alina Andras and Lisa Dikomitis 2022. Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review. Global health research and policy. 7 (34). https://doi.org/10.1186/s41256-022-00266-y
Community-based interventions for the prevention and control of Cutaneous Leishmaniasis: A systematic review
Kay Polidano, Brianne Wenning, Alejandra Ruiz-Cadavid, Baheya Dawaishan, Jay Panchal, Sonali Gunasekara, Haftom Abebe, Marciglei Morais, Helen Price and Lisa Dikomitis 2022. Community-based interventions for the prevention and control of Cutaneous Leishmaniasis: A systematic review. Social Sciences. 11 (10), p. 490. https://doi.org/2076-0760/11/10/490
VStore: Feasibility and acceptability of a novel virtual reality functional cognition task
Lilla A. Porffy, Mitul A. Mehta, Elias Mouchlianitis and Sukhi S. Shergill 2022. VStore: Feasibility and acceptability of a novel virtual reality functional cognition task. Frontiers in Virtual Reality.
Embedding behavioral and social sciences across the medical curriculum: (Auto) ethnographic insights from medical schools in the United Kingdom
Dikomitis, Lisa, Wenning, B., Ghobrial, Andrew and Adams, K. 2022. Embedding behavioral and social sciences across the medical curriculum: (Auto) ethnographic insights from medical schools in the United Kingdom. Societies. 12 (4), p. 101. https://doi.org/10.3390/soc12040101
Rewriting the history of leishmaniasis in Sri Lanka: An untold story since 1904
Nuwangi, H., Weerakoon, Kosala Gayan, Agampodi, Thilini Chanchala, Price, Helen Philippa, Dikomitis, Lisa and Agampodi, Suneth Buddhika 2022. Rewriting the history of leishmaniasis in Sri Lanka: An untold story since 1904. PLoS Neglected Tropical Diseases. 16 (12), p. e0010918. https://doi.org/10.1371/journal.pntd.0010918
Alpha3/alpha2 power ratios relate to performance on a virtual reality shopping task in ageing adults
Patchitt, Joel, Porffy, Lilla A., Whomersley, Gabriella, Szentgyorgyi, Timea, Brett, Jack, Mouchlianitis, Elias, Mehta, Mitul A., Nottage, Judith F. and Shergill, Sukhi S. 2022. Alpha3/alpha2 power ratios relate to performance on a virtual reality shopping task in ageing adults. Frontiers in Aging Neuroscience. 14, p. 876832. https://doi.org/10.3389/fnagi.2022.876832
Patients' and healthcare professionals' perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study.
Khattak, Maria Ishaq, Dikomitis, Lisa, Khan, Muhammad Firaz, Haq, Mukhtar Ul, Saeed, Umaima, Awan, Naila Riaz, Haq, Zia Ul, Shepherd, Thomas, Mallen, Christian D and Farooq, S. 2022. Patients' and healthcare professionals' perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study. PLoS ONE. 17 (8), p. e0273286. https://doi.org/10.1371/journal.pone.0273286
The influence of trial-by-trial feedback on trust in health, first-episode and chronic psychosis
Lemmers-Jansen, I., Wichmann, Rune J., Perizonius, Sophie and Shergill, Sukhi S. 2022. The influence of trial-by-trial feedback on trust in health, first-episode and chronic psychosis. Games. 13 (5), p. e59. https://doi.org/10.3390/g13050059
Vortioxetine as adjunctive therapy in the treatment of schizophrenia
Redaelli, Sofia, Porffy, Lilla, Oloyede, Ebenezer, Dzahini, O., Lewis, Gabriella, Lobo, Maria, Whiskey, E. and Shergill, Sukhi S. 2022. Vortioxetine as adjunctive therapy in the treatment of schizophrenia. Therapeutic Advances in Psychopharmacology. 12, p. 204512532211100. https://doi.org/10.1177/20451253221110014
Culture, migration, Brexit, and COVID-19: managing the mental health of patients from Central and Eastern Europe
Poppleton, Aaron, Saunders, Caroline, Chew-Graham, Carolyn A, Kingstone, Tom, Chudyk, Adrian and Dikomitis, Lisa 2022. Culture, migration, Brexit, and COVID-19: managing the mental health of patients from Central and Eastern Europe. The British Journal of General Practice : The Journal of the Royal College of General Practitioners. 72 (720), pp. 308-309. https://doi.org/72/720/308
Placing Leishmaniasis in the limelight through the communicable disease surveillance system: An experience from Sri Lanka
Gunasekara, S., Nuwangi, H., Wickramasinghe, N., Weerakoon, Kosala, Price, H., Dikomitis, Lisa and Agampodi, Suneth Buddhika 2022. Placing Leishmaniasis in the limelight through the communicable disease surveillance system: An experience from Sri Lanka. Pathogens (Basel, Switzerland). 11 (6), p. 680. https://doi.org/pathogens11060680
Burnout among primary health-care professionals in low- and middle-income countries: systematic review and meta-analysis
Wright, Tanya, Mughal, Faraz, Babatunde, Opeyemi O., Dikomitis, Lisa, Mallen, Christian D. and Helliwell, Toby 2022. Burnout among primary health-care professionals in low- and middle-income countries: systematic review and meta-analysis. Bulletin of the World Health Organization. 100 (6), pp. 385-401A. https://doi.org/10.2471/BLT.22.288300
The role of cognitive control in the positive symptoms of psychosis
Horne, Charlotte M., Sahni, Angad, Pang, Sze W., Vanes, Lucy D., Szentgyorgyi, Timea, Averbeck, Bruno, Moran, Rosalyn J. and Shergill, Sukhwinder S. 2022. The role of cognitive control in the positive symptoms of psychosis. NeuroImage. Clinical. 34, p. 103004. https://doi.org/S2213-1582(22)00069-9
Direct eye gaze enhances the ventriloquism effect
Lavan, N., Chan, Wing Yue, Zhuang, Yongping, Mareschal, Isabelle and Shergill, Sukhwinder S. 2022. Direct eye gaze enhances the ventriloquism effect. Attention, Perception & Psychophysics. https://doi.org/10.3758/s13414-022-02468-5
Community engagement in Cutaneous Leishmaniasis research in Brazil, Ethiopia, and Sri Lanka: A decolonial approach for global health.
Polidano, Kay, Parton, Linda, Agampodi, Suneth B, Agampodi, Thilini C, Haileselassie, Binega H, Lalani, Jayasundara M G, Mota, Clarice, Price, Helen P, Rodrigues, Steffane, Tafere, Getachew R, Trad, Leny A B, Zerihun, Zenawi and Dikomitis, Lisa 2022. Community engagement in Cutaneous Leishmaniasis research in Brazil, Ethiopia, and Sri Lanka: A decolonial approach for global health. Frontiers in Public Health. 10, p. 823844. https://doi.org/10.3389/fpubh.2022.823844
What does "good" community and public engagement look like? Developing relationships with community members in global health research
Hickey, Gary, Porter, Katie, Tembo, Doreen, Rennard, Una, Tholanah, Martha, Beresford, Peter, Chandler, David, Chimbari, Moses, Coldham, Tina, Dikomitis, Lisa, Dziro, Biggy, Ekiikina, Peter O, Khattak, Maria I, Montenegro, Cristian R, Mumba, Noni, Musesengwa, Rosemary, Nelson, Erica, Nhunzvi, Clement, Ramirez, Caroline M and Staniszewska, Sophie 2022. What does "good" community and public engagement look like? Developing relationships with community members in global health research. Frontiers in Public Health. 9, p. 776940. https://doi.org/10.3389/fpubh.2021.776940
The perceptions of general practice among Central and Eastern Europeans in the United Kingdom: A systematic scoping review
Poppleton, A., Howells, K., Adeyemi, I., Chew‐Graham, C., Dikomitis, L. and Sanders, C. 2022. The perceptions of general practice among Central and Eastern Europeans in the United Kingdom: A systematic scoping review. Health Expectations. https://doi.org/10.1111/hex.13433
Cutaneous leishmaniasis and mental health: Exploring psychosocial impact and CL-associated stigma (the ECLIPSE programme)
Dikomitis, L., Agampodi, Suneth Buddhika, Machado, P., Mulugeta, Afework, Trad, Leny A. B. and Price, Helen 2021. Cutaneous leishmaniasis and mental health: Exploring psychosocial impact and CL-associated stigma (the ECLIPSE programme). Research Meeting and Webinar on Cutaneous Leishmaniasis (CL): Research and development for neglected diseases and associated social issues. 49 (2), pp. 201-209.
The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial
James Gilleen, Judith Nottage, Farah Yakub, Sarah Kerins, Lorena Valdearenas, Tolga Uz, Gez Lahu, Max Tsai, Frank Ogrinc, Steve C Williams, Dominic Ffytche, Mitul A Mehta and Sukhi Shergill 2021. The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial. Journal of Psychopharmacology. 35 (1), pp. 15-22. https://doi.org/10.1177/0269881120946300
Cognitive performance in early, treatment-resistant psychosis patients: Could cognitive control play a role in persistent symptoms?
Shergill, S., Megan Thomas, Timea Szentgyorgy, Lucy D. Vanes, Elias Mouchlianitis, Erica F. Barry, Krisna Patel, Katie Wong and Dan Joyce 2021. Cognitive performance in early, treatment-resistant psychosis patients: Could cognitive control play a role in persistent symptoms? Psychiatry Research. 295, p. 113607.
If not now, when? Enhancing cardiologists’ psychological well-being as a COVID-19 gain
Rishi K Patel, Mark D Sweeney, Christopher S R Baker, Neil Greenberg, Susan E Piper, Sukhi S. Shergill, Derek K Tracy and Carla M Plymen 2021. If not now, when? Enhancing cardiologists’ psychological well-being as a COVID-19 gain. Heart. 2021 (107), pp. 593-595. https://doi.org/10.1136/heartjnl-2020-318852
An evaluation of the variation and underuse of clozapine in the United Kingdom
Eromona Whiskey, Alex Barnard, Ebenezer Oloyede, Olubanke Dzahini, David M. Taylor and Sukhwinder S. Shergill 2021. An evaluation of the variation and underuse of clozapine in the United Kingdom. Acta Psychiatrica Scandinavica. 143 (4), pp. 339-347. https://doi.org/10.1111/acps.13280
There is life after the UK Clozapine Central Non-Rechallenge Database
Ebenezer Oloyede, Cecilia Casetta, Olubanke Dzahini, Aviv Segev, Fiona Gaughran, Sukhi Shergill, Alek Mijovic, Marinka Helthuis, Eromona Whiskey, James Hunter MacCabe and David Taylor 2021. There is life after the UK Clozapine Central Non-Rechallenge Database . Schizophrenia Bulletin. 47 (4), pp. 1088-1098. https://doi.org/10.1093/schbul/sbab006
Effective engagement and involvement with community stakeholders in the co-production of global health research
Doreen Tembo, Gary Hickey, Cristian Montenegro, David Chandler, Erica Nelson, Katie Porter, Lisa Dikomitis, Lisa Dikomitis, Mary Chambers, Moses Chimbari, Peter Beresford, Peter O Ekiikina, Rosemary Musesengwa, Sophie Staniszewska, Tina Coldham and Una Rennard 2021. Effective engagement and involvement with community stakeholders in the co-production of global health research. British Medical Journal (BMJ). 2021 (372), p. n178. https://doi.org/10.1136/bmj.n178
The effect of training intensity on implicit learning rates in schizophrenia
Natasza D. Orlov, Jessica Sanderson, Syed Ali Muqtadir, Anastasia K. Kalpakidou, Panayiota G. Michalopoulou, Jie Lu and Sukhi S. Shergill 2021. The effect of training intensity on implicit learning rates in schizophrenia. Scientific Reports. 11 (6511). https://doi.org/10.1038/s41598-021-85686-5
Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis
Ismail Yahaya, Tanya Wright, Opeyemi O. Babatunde, Nadia Corp, Toby Helliwell, Lisa Dikomitis and Christian D. Mallen 2021. Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis. Rheumatology International. 41, pp. 1221-1231. https://doi.org/10.1007/s00296-021-04838-y
Preliminary evidence for the phosphodiesterase type-4 inhibitor, roflumilast, in ameliorating cognitive flexibility deficits in patients with schizophrenia
Nicholas R Livingston, Peter CT Hawkins, James Gilleen, Rong Ye, Lorena Valdearenas, Sukhi Shergill and Mitul A Mehta 2021. Preliminary evidence for the phosphodiesterase type-4 inhibitor, roflumilast, in ameliorating cognitive flexibility deficits in patients with schizophrenia. Journal of Psychopharmacology. 35 (9). https://doi.org/10.1177/02698811211000778
Contextual perception under active inference
Berk Mirza, M., Cullen, M., Parr, T., Shergill, S. and Moran, R. 2021. Contextual perception under active inference. Scientific Reports. 11 (16223). https://doi.org/s41598-021-95510-9
Experiences of general practice care for self-harm: A qualitative study of young people's perspectives
Mughal, F., Dikomitis, L., Babtunde, O.O. and Chew-Graham, C. A. 2021. Experiences of general practice care for self-harm: A qualitative study of young people's perspectives. British Journal of General Practice (BJGP). 71 (711), pp. 3744-e752. https://doi.org/10.3399/BJGP.2021.0091
Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations
Shergill, S., Amir Krivoy, Eromona Whiskey, Henrietta Webb-Wilson, Dan Joyce, Derek K. Tracy, Fiona Gaughran, James H. MacCabe and Sukhwinder S. Shergill 2021. Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations. Therapeutic Advances in Psychopharmacology. 11. https://doi.org/10.1177/20451253211037179
How medical students in the United Kingdom think: About anthropology, for example
Dikomitis, L. 2021. How medical students in the United Kingdom think: About anthropology, for example. in: Martinez, I. and Wiedman, D. W. (ed.) Anthropology in Medical Education: Sustaining Engagement and Impact Cham Springer. pp. 91-113
New approaches to antipsychotic medication adherence – safety, tolerability and acceptability
Taub, Sharon, Krivoy, Amir, Whiskey, Eromona and Shergill, Sukhi S. 2021. New approaches to antipsychotic medication adherence – safety, tolerability and acceptability. Expert Opinion on Drug Safety. 21 (4), pp. 517-524. https://doi.org/10.1080/14740338.2021.1983540
A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia
di Hou, Meng, Santoro, Viviana, Biondi, Andrea, Shergill, Sukhi S and Premoli, Isabella 2021. A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia. Journal of psychiatry & neuroscience : JPN. 46 (6), pp. E675-E701. https://doi.org/10.1503/jpn.210006
Patients' perspectives on flares in knee osteoarthritis: a qualitative study
Parry, E., Dikomitis, L., Peat, G. and Chew-Graham, C. 2020. Patients' perspectives on flares in knee osteoarthritis: a qualitative study. Osteoarthritis and Cartilage. 28 (S1), p. S392. https://doi.org/10.1016/j.joca.2020.02.611
Why care about integrated care? Part 2. Integrated care systems: an irresistible force changing mental health services
Tracy, D. K., Holloway, F., Hanson, K., Kanani, N., Trainer, M., Dimond, I., James, A., Kalidini, S. and Shergill, S. 2020. Why care about integrated care? Part 2. Integrated care systems: an irresistible force changing mental health services. BJPsych Advances. 29 (1), pp. 19-30. https://doi.org/10.1192/bja.2020.3
Why care about integrated care? Part I. Demographics, finances and workforce: immovable objects facing mental health services
Tracy, D. K., Holloway, F., Hanson, K., James, A., Strathdee, G., Holmes, D., Kalidini, S. and Shergill, S. 2020. Why care about integrated care? Part I. Demographics, finances and workforce: immovable objects facing mental health services. BJPsych Advances. 29 (1), pp. 8-18. https://doi.org/10.1192/bja.2019.78
A retrospective study of intramuscular clozapine prescription for treatment initiation and maintenance in treatment-resistant psychosis
Whiskey, E., Shergill, S. and Dzahini, O. 2020. A retrospective study of intramuscular clozapine prescription for treatment initiation and maintenance in treatment-resistant psychosis. British Journal of Psychiatry.
Schizophrenia polygenic risk score influence on white matter microstructure
Beatriz Simões, Evangelos Vassos, Sukhi Shergill, Colm McDonald, Timothea Toulopoulou, Sridevi Kalidindi, Fergus Kane, Robin Murray, Elvira Bramon, Hugo Ferreira and Diana Prata 2020. Schizophrenia polygenic risk score influence on white matter microstructure. Journal of Psychiatric Research. 121, pp. 62-67. https://doi.org/10.1016/j.jpsychires.2019.11.011
In the eye of the beholder? Oxytocin effects on eye movements in schizophrenia
Lilla A. Porffy, Victoria Bell, Antoine Coutrot, Rebekah Wigton, Teresa D'Oliveira, Isabelle Mareschal and Sukhwinder S. Shergill 2020. In the eye of the beholder? Oxytocin effects on eye movements in schizophrenia. Schizophrenia Research. 216, pp. 279-287.
Role of the GP in the management of patients with self-harm behaviour: A systematic review
Dikomitis, L., Faraz Mughal, M. Isabela Troya, Lisa Dikomitis, Carolyn A. Chew-Graham, Nadia Corp and Opeyemi O Babatunde 2020. Role of the GP in the management of patients with self-harm behaviour: A systematic review. British Journal of General Practice (BJGP). 70 (694), pp. e364-e373. https://doi.org/10.3399/bjgp20X708257
Development and evaluation of a screening tool to aid the diagnosis of a cluster headache
Alina Buture, Jason W. Boland, Lisa Dikomitis, Chao Huang and Fayyaz Ahmed 2020. Development and evaluation of a screening tool to aid the diagnosis of a cluster headache. Brain Sciences. 10 (2), p. 77. https://doi.org/10.3390/brainsci10020077
Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces
Sukhi Shergill, Evangelos Papanastasiou, Elias Mouchlianitis, Dan W. Joyce, Philip McGuire, Celia Boussebaa, Tobias Banaschewski, Arun L. W. Bokde, Christian Büchel, Erin Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Philip Spechler, Penny Gowland, Andreas Heinz, Bernd Ittermann, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sabina Millenet, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann and Sukhwinder S. Shergill 2020. Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces. Scientific Reports. 10, p. 5164. https://doi.org/10.1038/s41598-020-62026-7
Cognitive remediation for inpatients with psychosis: a systematic review and meta-analysis
Matteo Cella, Tom Price, Holly Corboy, Juliana Onwumere, Sukhi Shergill and Antonio Preti 2020. Cognitive remediation for inpatients with psychosis: a systematic review and meta-analysis. Psychological Medicine. 50 (7), pp. 1062-1076. https://doi.org/10.1017/S0033291720000872
Biased interpretation in paranoia and its modification
George Savulich, Annabel Edwards, Sara Assadi, Husniye Guven, Emily Leathers-Smith, Sukhi Shergill and Jenny Yiend 2020. Biased interpretation in paranoia and its modification. Journal of Behavior Therapy and Experimental Psychiatry. 69, p. 101575. https://doi.org/10.1016/j.jbtep.2020.101575
Acute oxytocin effects in inferring others' beliefs and social emotions in people at clinical high risk for psychosis
André Schmidt, Cathy Davies, Yannis Paloyelis, Nicholas Meyer, Andrea De Micheli, Valentina Ramella-Cravaro, Umberto Provenzani, Yuta Aoki, Grazia Rutigliano, Marco Cappucciati, Dominic Oliver, Silvia Murguia, Fernando Zelaya, Paul Allen, Sukhi Shergill, Paul Morrison, Steve Williams, David Taylor, Stefan Borgwardt, Hidenori Yamasue, Philip McGuire and Paolo Fusar-Poli 2020. Acute oxytocin effects in inferring others' beliefs and social emotions in people at clinical high risk for psychosis. Translational Psychiatry. 10 (203). https://doi.org/10.1038/s41398-020-00885-4
Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan
Thomas Andrew Shepherd, Zia Ul-Haq, Mian Ul-Haq, Muhammad Firaz Khan, Adil Afridi, Lisa Dikomitis, Michelle E Robinson, Martyn Lewis, Atif Rahman, Krysia Dziedzic, Umaima Saeed, Naila Riaz Awan, Christian Mallen and Saeed Farooq 2020. Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan. BMJ Open. 2020 (10), p. e034709. https://doi.org/10.1136/bmjopen-2019-034709
Perceptions, experiences, and understandings of cluster headache among GPs and neurologists: a qualitative study
Alina Buture, Fayyaz Ahmed, Yachna Mehta, Koen Paemeleire, Peter J Goadsby and Lisa Dikomitis 2020. Perceptions, experiences, and understandings of cluster headache among GPs and neurologists: a qualitative study. British Journal of General Practice (BJGP). 70 (696), pp. e514-e522. https://doi.org/10.3399/bjgp20X710417
Real-world effectiveness of admissions to a tertiary treatment-resistant psychosis service: 2-year mirror-image study
Cecilia Casetta, Fiona Gaughran, Ebenezer Oloyede, Juliana Onwumere, Megan Pritchard, Sukhi S. Shergill, Eromona Whiskey and James Hunter MacCabe 2020. Real-world effectiveness of admissions to a tertiary treatment-resistant psychosis service: 2-year mirror-image study. BJPsych Open. 6 (5), p. E82. https://doi.org/10.1192/bjo.2020.51
Guidelines for the use of diagnostic imaging in musculoskeletal pain conditions affecting the lower back, knee and shoulder: A scoping review
Andrew Cuff, Stephen Parton, Robert Tyer, Lisa Dikomitis, Nadine Foster and Chris Littlewood 2020. Guidelines for the use of diagnostic imaging in musculoskeletal pain conditions affecting the lower back, knee and shoulder: A scoping review. Musculoskeletal Care. 18 (4), p. 5460554. https://doi.org/10.1002/msc.1497
Rehabilitation following rotator cuff repair: A multi-centre pilot & feasibility randomised controlled trial (RaCeR)
Chris Littlewood, Marcus Bateman, Stephanie Butler-Walley, Sarah Bathers, Kieran Bromley, Martyn Lewis, Lennard Funk, Jean Denton, Maria Moffatt, Rachel Winstanley, Saurabh Mehta, Gareth Stephens, Lisa Dikomitis and Nadine E Foster 2020. Rehabilitation following rotator cuff repair: A multi-centre pilot & feasibility randomised controlled trial (RaCeR). Clinical Rehabilitation. 35 (6), pp. 829-836. https://doi.org/10.1177/0269215520978859
Rehabilitation following rotator cuff repair: A nested qualitative study exploring the perceptions and experiences of participants in a randomised controlled trial
Stephens, G., Littlewood, C., Foster, N. E. and Dikomitis, L. 2020. Rehabilitation following rotator cuff repair: A nested qualitative study exploring the perceptions and experiences of participants in a randomised controlled trial. Clinical Rehabilitation. 35 (6), pp. 911-919. https://doi.org/10.1177/0269215520984025
The politics of restoring religious sites and cemeteries in the north of Cyprus: an ethnography among Greek Cypriot refugees
Dikomitis, L. and Argyrou, V. 2020. The politics of restoring religious sites and cemeteries in the north of Cyprus: an ethnography among Greek Cypriot refugees. in: Kruse, T., Faustmann, H. and Rogge, S. (ed.) When the Cemetery Becomes Political - Dealing with the Religious Heritage in Multi-Ethnic Regions Munich and New York University of Münster.
Understanding self-harm in older adults: a qualitative study
M. Isabela Troya, Lisa Dikomitis, Opeyemi O. Babatunde, Bernadette Bartlam and Carolyn A. Chew-Graham 2019. Understanding self-harm in older adults: a qualitative study. eClinicalMedicine. 12, pp. 52-61. https://doi.org/10.1016/j.eclinm.2019.06.002
Self-harm in older adults: Systematic review
M. Isabela Troya, Opeyemi Babatunde, Kay Polidano, Bernadette Bartlam, McCloskey, E., Lisa Dikomitis and Carolyn A. Chew-Graham 2019. Self-harm in older adults: Systematic review. British Journal of Psychology. 214 (4), pp. 186-200. https://doi.org/10.1192/bjp.2019.11
Dopamine manipulations drive changes in information sampling in healthy volunteers
Shergill, S. 2019. Dopamine manipulations drive changes in information sampling in healthy volunteers. Journal of Psychopharmacology. 33 (6), pp. 670-677. https://doi.org/10.1177/0269881118822080
Integrated care in mental health: Next steps after the NHS Long Term Plan
Derek K. Tracy, Kara Hanson, Tom Brown, Adrian J. B. James, Holly Paulsen, Zoé Mulliez and Sukhwinder Shergill 2019. Integrated care in mental health: Next steps after the NHS Long Term Plan. British Journal of Psychiatry. 214 (6), pp. 315-317. https://doi.org/10.1192/bjp.2019.46
Cognitive correlates of abnormal myelination in psychosis
Lucy D. Vanes, Elias Mouchlianitis, Erica Barry, Krisna Patel, Katie Wong and Sukhwinder S. Shergill. 2019. Cognitive correlates of abnormal myelination in psychosis. Scientific Reports. 9 (5162). https://doi.org/10.1038/s41598-019-41679-z
Self-harm in young people: the exceptional potential of the general practice consultation
Faraz Mughal, Opeyemi Babatunde, Lisa Dikomitis, Judith Shaw, Ellen Townsend, M. Isabela Troya and Carolyn A. Chew-Graham 2019. Self-harm in young people: the exceptional potential of the general practice consultation. British Journal of General Practice (BJGP). 69 (681), pp. 168-169. https://doi.org/10.3399/bjgp19X701393
Patient and public involvement and engagement in a doctoral research project exploring self-harm in older adults
M. Isabela Troya, Carolyn A. Chew-Graham, Opeyemi Babatunde, Bernadette Bartlam, Adele Higginbottom and Lisa Dikomitis 2019. Patient and public involvement and engagement in a doctoral research project exploring self-harm in older adults. Health Expectations. 22 (4), pp. 617-631. https://doi.org/10.1111/hex.12917
Protocol for a multi-centre pilot and feasibility randomised controlled trial with a nested qualitative study: rehabilitation following rotator cuff repair (the RaCeR study)
Chris Littlewood, Marcus Bateman, Kendra Cooke, Susie Hennnings, Tina Cookson, Kieran Bromley, Martyn Lewis, Lennard Funk, Jean Denton, Maria Moffatt, Rachel Winstanley, Saurabh Mehta, Gareth Stephens, Lisa Dikomitis, Linda Chesterton and Nadine E. Foster 2019. Protocol for a multi-centre pilot and feasibility randomised controlled trial with a nested qualitative study: rehabilitation following rotator cuff repair (the RaCeR study). Trials. 20 (328). https://doi.org/10.1186/s13063-019-3407-3
Exploring differences in individual and group judgements in standard setting
Peter Yeates, Natalie Cope, Eva Luksaite, Andrew Hassell and Lisa Dikomitis 2019. Exploring differences in individual and group judgements in standard setting. Medical Education. 53 (9), pp. 941-962. https://doi.org/10.1111/medu.13915
Clozapine and cardiotoxicity – A guide for psychiatrists written by cardiologists
Rishi K. Patel, Alice M. Moore, Susan Piper, Mark Sweeney, Eromona Whiskey, Graham Cole, Suhki Shergill and Carla M. Plymen 2019. Clozapine and cardiotoxicity – A guide for psychiatrists written by cardiologists. Psychiatry Research. 282, p. 112491. https://doi.org/10.1016/j.psychres.2019.112491
Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study
Dikomitis, L. 2019. Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study. Journal of Multidisciplinary Healthcare. 2019 (12), pp. 691-698. https://doi.org/10.2147/JMDH.S207128
Understanding and managing cardiac side-effects of second-generation antipsychotics in the treatment of schizophrenia
Mark Sweeney, Eromona Whiskey, Rishi K. Patel, Derek K. Tracy, Sukhi S. Shergill and Carla M. Plymen 2019. Understanding and managing cardiac side-effects of second-generation antipsychotics in the treatment of schizophrenia. BJPsych Advances. 26 (1), pp. 26-40. https://doi.org/10.1192/bja.2019.49
Real-world outcomes in the management of refractory psychosis
Amir Krivoy, Dan Joyce, Derek Tracy, Fiona Gaughran, James MacCabe, John Lally, Eromona Whiskey, S. Neil Sarkar and Sukhwinder S. Shergill 2019. Real-world outcomes in the management of refractory psychosis. Journal of Clinical Psychiatry. 80 (5), p. 18m12716. https://doi.org/10.4088/JCP.18m12716
Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia
Lucy D. Vanes, Elias Mouchlianitis, Krisna Patel, Erica Barry, Katie Wong, Megan Thomas, Timea Szentgyorgyi, Dan Joyce and Sukhwinder Shergill 2019. Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia. Scientific Reports. 9, p. 14444. https://doi.org/10.1038/s41598-019-51023-0
Images depicting pain: a screening tool for cluster headache
Buture, A., Dikomitis, L., Boland, L. and Ahmed, F. 2018. Images depicting pain: a screening tool for cluster headache. Cephalalgia. 38 (Supp 1), pp. 114-115. https://doi.org/10.1177/0333102418789865
Delays in the diagnosis and misdiagnosis of cluster headache – a systematic literature review
Buture, A., Boland, J. W., Dikomitis, L. and Ahmed, F. 2018. Delays in the diagnosis and misdiagnosis of cluster headache – a systematic literature review. Cephalalgia. 38 (Supp 1), pp. MTIS2018-145.
Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache
Buture, A., Boland, J. W., Dikomitis, L. and Ahmed, F. 2018. Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache. Neurological Sciences. 40, pp. 25-39. https://doi.org/10.1007/s10072-018-3598-5
Visual images: an additional tool for the screening of cluster headache
Buture, A., Dikomitis, L., Boland, J. W. and Ahmed, F. 2017. Visual images: an additional tool for the screening of cluster headache. Cephalalgia. 37, p. 219.
So looking at this, you look like you've got some issues going on with your joints: Exploring case-finding in long-tern condition review consultations - the ENHANCE pilot trial
Liddle, J., Chew-Graham, C. A., Mallen, C. D., Healey, E. L., Jinks, C. and Dikomitis, L. 2017. So looking at this, you look like you've got some issues going on with your joints: Exploring case-finding in long-tern condition review consultations - the ENHANCE pilot trial. Rheumatology. 56 (IS 2). https://doi.org/10.1093/rheumatology/kex062.181
Girls-boys: an investigation of gender differences in the behavioral and neural mechanisms of trust and reciprocity in adolescence
Imke L. J. Lemmers-Jansen, Anne-Kathrin J. Fett, Sukhi Shergill, Marlieke T. R. van Kesteren and Lydia Krabbendam 2017. Girls-boys: an investigation of gender differences in the behavioral and neural mechanisms of trust and reciprocity in adolescence. Frontiers in Human Neuroscience. 13 (257).
'"The man who closed the asylums": Franco Basaglia and the revolution in mental health care', by John Foot (Verso, 2015)
Dikomitis, L. 2016. '"The man who closed the asylums": Franco Basaglia and the revolution in mental health care', by John Foot (Verso, 2015). Durham University Institute for Medical Humanities.
How do clinicians think about cluster headache
Dikomitis, L., Paemeleire, K., Goadsby, P. J. and Ahmed, F. 2016. How do clinicians think about cluster headache. Cephalalgia. 36 (S 1).
Developing a diagnostic tool for the early diagnosis of cluster headache
Buture, A., Dikomitis, L. and Ahmed, F. 2016. Developing a diagnostic tool for the early diagnosis of cluster headache. Cephalalgia.
Perceptions, understandings and experiences of cluster headache patients in the north of England: a qualitative study
Dikomitis, L., Quarshie, V., Paemeleire, K., Goadsby, P. J. and Ahmed, F. 2015. Perceptions, understandings and experiences of cluster headache patients in the north of England: a qualitative study. Cephalalgia. 25 (S6).
[Review of] The Past in Pieces: Belonging in the New Cyprus, by Rebecca Bryant. Contemporary Ethnography series. Philadelphia: University of Pennsylvania Press, 2010. 224 pp.
Dikomitis, L. 2014. [Review of] The Past in Pieces: Belonging in the New Cyprus, by Rebecca Bryant. Contemporary Ethnography series. Philadelphia: University of Pennsylvania Press, 2010. 224 pp. American Anthropologist. 116 (1), pp. 194-195. https://doi.org/10.1111/aman.12085_9
Perceptions and experiences of cluster headache among patients, general practitioners and neurologists in the north of england: A qualitative study
Ahmed, F., Dikomitis, L., Zafar, H. W., Goadsby, P. and Paemeliere, P. 2014. Perceptions and experiences of cluster headache among patients, general practitioners and neurologists in the north of england: A qualitative study. Journal of Headache and Pain. 15 (S1).
Patients perceptions of the causes of migraine in Flanders (Belgium): A qualitative study
Dikomitis, L., Bonte, M., Willems, S. and Paemeleire, K. 2013. Patients perceptions of the causes of migraine in Flanders (Belgium): A qualitative study. Cephalalgia. 33 (S 8), p. 198. https://doi.org/10.1177/0333102413490487