Vortioxetine as adjunctive therapy in the treatment of schizophrenia

Journal article

Redaelli, Sofia, Porffy, Lilla, Oloyede, Ebenezer, Dzahini, O., Lewis, Gabriella, Lobo, Maria, Whiskey, E. and Shergill, Sukhi S. 2022. Vortioxetine as adjunctive therapy in the treatment of schizophrenia. Therapeutic Advances in Psychopharmacology. 12, p. 204512532211100. https://doi.org/10.1177/20451253221110014
AuthorsRedaelli, Sofia, Porffy, Lilla, Oloyede, Ebenezer, Dzahini, O., Lewis, Gabriella, Lobo, Maria, Whiskey, E. and Shergill, Sukhi S.
AbstractBackground: The evidence for safe and effective interventions to treat the negative and cognitive symptoms of schizophrenia is lacking. Objectives: Vortioxetine is a novel antidepressant that has been used as adjunctive therapy for the treatment of psychosis; however, its effectiveness in clinical practice is relatively unknown. In this study, we aimed to determine the potential clinical effectiveness and safety and tolerability of vortioxetine in psychosis. Design: This is a non-interventional, retrospective study on the add-on use of vortioxetine in a group of people with schizophrenia-spectrum disorders in a large UK NHS mental health trust. Methods: Clinical effectiveness of vortioxetine was retrospectively assessed through the Clinical Global Impression – Severity (CGI-S) scale at 3 months. Safety and tolerability were evaluated through treatment discontinuation rates at 3, 6, and 12 months, and clinical reasons were evaluated at the primary endpoint of 3 months. Results: Data were available for 40 subjects with a diagnosis of schizophrenia or schizoaffective disorder–prescribed vortioxetine treatment; 30 (75%) remained on treatment at 3 months. At CGI-S assessment, 15 of the 35 evaluated subjects reported at least a 1-point improvement, from 5 at baseline to 4 after 3 months of treatment. Twenty-six (65%) remained on treatment at 1-year follow-up. The main reasons for those discontinuing treatment were inadequate response (10%) and manic switch (7.5%), while one subject refused treatment. Tolerability to treatment was good, and 36 subjects (90%) reported no adverse events specific to vortioxetine treatment. Conclusion: Schizophrenia is a complex illness, and there is insufficient treatment response in many individuals. A significant proportion of whom may require adjunctive treatments depending on the nature of the residual symptoms. Vortioxetine could be a potentially safe and effective option in such people, but further controlled studies are required.
KeywordsVortioxetine ; Schizophrenia; Treatment
Year2022
JournalTherapeutic Advances in Psychopharmacology
Journal citation12, p. 204512532211100
PublisherSAGE Publications
ISSN2045-1253
2045-1261
Digital Object Identifier (DOI)https://doi.org/10.1177/20451253221110014
Official URLhttps://journals.sagepub.com/doi/full/10.1177/20451253221110014
FunderKing's College London
Publication dates
Online05 Jul 2022
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Accepted08 Jun 2022
Deposited18 Jul 2022
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Lucy D. Vanes, Elias Mouchlianitis, Krisna Patel, Erica Barry, Katie Wong, Megan Thomas, Timea Szentgyorgyi, Dan Joyce and Sukhwinder Shergill 2019. Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia. Scientific Reports. 9, p. 14444. https://doi.org/10.1038/s41598-019-51023-0
Girls-boys: an investigation of gender differences in the behavioral and neural mechanisms of trust and reciprocity in adolescence
Imke L. J. Lemmers-Jansen, Anne-Kathrin J. Fett, Sukhi Shergill, Marlieke T. R. van Kesteren and Lydia Krabbendam 2017. Girls-boys: an investigation of gender differences in the behavioral and neural mechanisms of trust and reciprocity in adolescence. Frontiers in Human Neuroscience. 13 (257).