Stimulating learning: A functional MRI and behavioral investigation of the effects of transcranial direct current stimulation on stochastic learning in schizophrenia

Journal article


Natasza D. Orlov, Syed Ali Muqtadir, Hooman Oroojeni, Bruno Averbeck, John Rothwell and Sukhi S. Shergill 2022. Stimulating learning: A functional MRI and behavioral investigation of the effects of transcranial direct current stimulation on stochastic learning in schizophrenia. Psychiatry Research. 317, p. 114908. https://doi.org/10.1016/j.psychres.2022.114908
AuthorsNatasza D. Orlov, Syed Ali Muqtadir, Hooman Oroojeni, Bruno Averbeck, John Rothwell and Sukhi S. Shergill
Abstract

Transcranial direct current stimulation (tDCS) of the medial prefrontal cortex (mPFC) is under clinical investigation as a treatment for cognitive deficits. We investigate the effects of tDCS over the mPFC on performance SSLT in individuals with schizophrenia, and the underlying neurophysiological effect in regions associated with learning values and stimulus-outcome relationships. In this parallel-design double-blind pilot study, 49 individuals with schizophrenia, of whom 28 completed a fMRI, were randomized into active or sham tDCS stimulation groups. Subjects participated in 4 days of SSLT training (days 1, 2, 14, 56) with tDCS applied at day-1, and during a concurrent MRI scan at day-14. The SSLT demonstrated a significant mean difference in performance in the tDCS treatment group: at day-2 and at day-56. Active tDCS was associated with increased insular activity, and reduced amygdala activation. tDCS may offer an important novel approach to modulating brain networks to ameliorate cognitive deficits in schizophrenia, with this study being the first to show a longer-term effect on SSLT.

KeywordsImaging ; Schizophrenia; tDCS; Stochastic learning; Neuromodulation; Cognition; Cognitive defects
Year2022
JournalPsychiatry Research
Journal citation317, p. 114908
PublisherElsevier
ISSN0165-1781
Digital Object Identifier (DOI)https://doi.org/10.1016/j.psychres.2022.114908
Official URLhttps://www.sciencedirect.com/science/article/pii/S0165178122004991
Publication dates
Online21 Oct 2022
Publication process dates
Accepted13 Oct 2022
Deposited24 May 2023
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https://repository.canterbury.ac.uk/item/94q9x/stimulating-learning-a-functional-mri-and-behavioral-investigation-of-the-effects-of-transcranial-direct-current-stimulation-on-stochastic-learning-in-schizophrenia

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