Understanding and managing cardiac side-effects of second-generation antipsychotics in the treatment of schizophrenia

Journal article

Mark Sweeney, Eromona Whiskey, Rishi K. Patel, Derek K. Tracy, Sukhi S. Shergill and Carla M. Plymen 2019. Understanding and managing cardiac side-effects of second-generation antipsychotics in the treatment of schizophrenia. BJPsych Advances. 26 (1), pp. 26-40. https://doi.org/10.1192/bja.2019.49
AuthorsMark Sweeney, Eromona Whiskey, Rishi K. Patel, Derek K. Tracy, Sukhi S. Shergill and Carla M. Plymen
Abstract

Second-generation antipsychotic medications (SGAs) have advanced the treatment of schizophrenia over the past 30 years. However, a number of potentially life-threatening cardiac side-effects associated with these treatments concern and can discourage prescribers from administering these evidence-based treatments. This review provides a practical, psychiatrist-oriented understanding of the relative frequencies, mechanisms, investigations and treatments associated with these cardiac toxicities. We aim to highlight that these are relatively rare complications of an effective class of drug and to promote the advantages of early involvement of cardiologists in the psychiatric multidisciplinary team to guide the investigation and management of these conditions.

KeywordsAntipsychotics; Cardiomyopathy; Myocarditis; Sudden death; Tachycardia
Year2019
JournalBJPsych Advances
Journal citation26 (1), pp. 26-40
PublisherCambridge University Press
ISSN2056-4678
2056-4686
Digital Object Identifier (DOI)https://doi.org/10.1192/bja.2019.49
Official URLhttps://doi.org/10.1192/bja.2019.49
Publication dates
Online11 Sep 2019
Publication process dates
Deposited23 Jun 2023
Output statusPublished
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