Understanding the mechanisms underlying cognitive control in psychosis

Journal article

Maitra, R., Lemmers-Jansen, I L J, Vooren, M, Vanes, Lucy, Szentgyorgyi, Timea, Crisp, Charlotte, Mouchlianitis, Elias and Shergill, S S 2024. Understanding the mechanisms underlying cognitive control in psychosis. Psychological Medicine. https://doi.org/10.1017/S0033291724001119
AuthorsMaitra, R., Lemmers-Jansen, I L J, Vooren, M, Vanes, Lucy, Szentgyorgyi, Timea, Crisp, Charlotte, Mouchlianitis, Elias and Shergill, S S
AbstractCognitive control (CC) involves a top-down mechanism to flexibly respond to complex stimuli and is impaired in schizophrenia. This study investigated the impact of increasing complexity of CC processing in 140 subjects with psychosis and 39 healthy adults, with assessments of behavioral performance, neural regions of interest and symptom severity. The lowest level of CC (Stroop task) was impaired in all patients; the intermediate level of CC (Faces task) with explicit emotional information was most impaired in patients with first episode psychosis. Patients showed activation of distinct neural CC and reward networks, but iterative learning based on the higher-order of CC during the trust game, was most impaired in chronic schizophrenia. Subjects with first episode psychosis, and patients with lower symptom load, demonstrate flexibility of the CC network to facilitate learning, which appeared compromised in the more chronic stages of schizophrenia. These data suggest optimal windows for opportunities to introduce therapeutic interventions to improve CC.
KeywordsPsychosis; Trust; Schizophrenia; Neuroimaging; Cognitive control
Year2024
JournalPsychological Medicine
PublisherCambridge University Press
ISSN1469-8978
Digital Object Identifier (DOI)https://doi.org/10.1017/S0033291724001119
https://doi.org/S0033291724001119
Official URLhttps://www.cambridge.org/core/journals/psychological-medicine/article/understanding-the-mechanisms-underlying-cognitive-control-in-psychosis/9E517D9B4722E35738EC0440BBD16A6C
Publication dates
Online23 May 2024
Publication process dates
Deposited05 Jun 2024
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Open
Output statusPublished
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