Schizophrenia polygenic risk score influence on white matter microstructure
Journal article
Beatriz Simões, Evangelos Vassos, Sukhi Shergill, Colm McDonald, Timothea Toulopoulou, Sridevi Kalidindi, Fergus Kane, Robin Murray, Elvira Bramon, Hugo Ferreira and Diana Prata 2020. Schizophrenia polygenic risk score influence on white matter microstructure. Journal of Psychiatric Research. 121, pp. 62-67. https://doi.org/10.1016/j.jpsychires.2019.11.011
Authors | Beatriz Simões, Evangelos Vassos, Sukhi Shergill, Colm McDonald, Timothea Toulopoulou, Sridevi Kalidindi, Fergus Kane, Robin Murray, Elvira Bramon, Hugo Ferreira and Diana Prata |
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Abstract | Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles. |
Keywords | Ploygenic risk scores; PRS; Schizophrenia; Bipolar disorder; White matter; Diffusion tensor imaging; Psychosis; Fractional anisotropy; Mean diffusivity; GWA; Genome-wide association |
Year | 2020 |
Journal | Journal of Psychiatric Research |
Journal citation | 121, pp. 62-67 |
Publisher | Elsevier |
ISSN | 0022-3956 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jpsychires.2019.11.011 |
Official URL | https://www.sciencedirect.com/science/article/pii/S0022395619307137 |
Publication dates | |
Online | 19 Nov 2019 |
Publication process dates | |
Accepted | 18 Nov 2019 |
Deposited | 22 Jun 2023 |
Accepted author manuscript | License |
Output status | Published |
https://repository.canterbury.ac.uk/item/94y1v/schizophrenia-polygenic-risk-score-influence-on-white-matter-microstructure
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Accepted author manuscript
Bramon_Simoes Prata et al JPSYCHIATRRES_2019_651_Revision 2_V0_extracted.pdf | ||
License: CC BY-NC-ND 4.0 |
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