A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia

Journal article


di Hou, Meng, Santoro, Viviana, Biondi, Andrea, Shergill, Sukhi S and Premoli, Isabella 2021. A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia. Journal of psychiatry & neuroscience : JPN. 46 (6), pp. E675-E701. https://doi.org/10.1503/jpn.210006
Authorsdi Hou, Meng, Santoro, Viviana, Biondi, Andrea, Shergill, Sukhi S and Premoli, Isabella
AbstractTranscranial magnetic stimulation can be combined with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) to evaluate the excitatory and inhibitory functions of the cerebral cortex in a standardized manner. It has been postulated that schizophrenia is a disorder of functional neural connectivity underpinned by a relative imbalance of excitation and inhibition. The aim of this review was to provide a comprehensive overview of TMS-EMG and TMS-EEG research in schizophrenia, focused on excitation or inhibition, connectivity, motor cortical plasticity and the effect of antipsychotic medications, symptom severity and illness duration on TMS-EMG and TMS-EEG indices. We searched PsycINFO, Embase and Medline, from database inception to April 2020, for studies that included TMS outcomes in patients with schizophrenia. We used the following combination of search terms: transcranial magnetic stimulation OR tms AND interneurons OR glutamic acid OR gamma aminobutyric acid OR neural inhibition OR pyramidal neurons OR excita* OR inhibit* OR GABA* OR glutam* OR E-I balance OR excitation-inhibition balance AND schizoaffective disorder* OR Schizophrenia OR schizophreni*. TMS-EMG and TMS-EEG measurements revealed deficits in excitation or inhibition, functional connectivity and motor cortical plasticity in patients with schizophrenia. Increased duration of the cortical silent period (a TMS-EMG marker of γ-aminobutyric acid B receptor activity) with clozapine was a relatively consistent finding. Most of the studies used patients with chronic schizophrenia and medicated patients, employed cross-sectional group comparisons and had small sample sizes. TMS-EMG and TMS-EEG offer an opportunity to develop a novel and improved understanding of the physiologic processes that underlie schizophrenia and to assess the therapeutic effect of antipsychotic medications. In the future, these techniques may also help predict disease progression and further our understanding of the excitatory/inhibitory balance and its implications for mechanisms that underlie treatment-resistant schizophrenia. [Abstract copyright: © 2021 CMA Joule Inc. or its licensors.]
KeywordsSchizophrenia; Treatment; TMS; Transcranial magnetic stimulation; Electromyography; Electroencephalography
Year2021
JournalJournal of psychiatry & neuroscience : JPN
Journal citation46 (6), pp. E675-E701
ISSN1488-2434
Digital Object Identifier (DOI)https://doi.org/10.1503/jpn.210006
Official URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695525/
Publication dates
Online21 Dec 2021
Publication process dates
Accepted06 Sep 2021
Deposited12 Jan 2022
Supplemental file
License
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/900zw/a-systematic-review-of-tms-and-neurophysiological-biometrics-in-patients-with-schizophrenia

Download files


Supplemental file
TMSschizophrenia.pdf
License: CC BY-NC-ND 4.0

  • 46
    total views
  • 11
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Do loneliness and social exclusion breed paranoia? An experience sampling investigation across the psychosis continuum.
Bell, Victoria, Velthorst, Eva, Almansa, Jorge, Myin-Germeys, Inez, Shergill, Sukhi and Fett, Anne-Kathrin 2023. Do loneliness and social exclusion breed paranoia? An experience sampling investigation across the psychosis continuum. Schizophrenia Research: Cognition. 33, p. 100282. https://doi.org/10.1016/j.scog.2023.100282
Automatic detection of cognitive impairment with virtual reality
Mannan, Farzana A, Porffy, Lilla A, Joyce, Dan W, Shergill, Sukhwinder S and Celiktutan, O. 2023. Automatic detection of cognitive impairment with virtual reality. Sensors. 23 (2), p. 1026. https://doi.org/10.3390/s23021026
Neuroimaging oxytocin modulation of social reward learning in schizophrenia.
Mouchlianitis, Elias D, Tracy, D., Wigton, Rebekah, Vanes, Lucy D, Fett, A. and Shergill, Sukhi S 2022. Neuroimaging oxytocin modulation of social reward learning in schizophrenia. BJPsych Open. 8 (5), p. e175. https://doi.org/10.1192/bjo.2022.577
Cognitive bias modification for paranoia (CBM-pa): a randomised controlled feasibility study in patients with distressing paranoid beliefs.
Yiend, Jenny, Lam, C., Schmidt, Nora, Crane, Bryony, Heslin, Margaret, Kabir, Thomas, McGuire, Philip, Meek, Christopher, Mouchlianitis, Elias, Peters, Emmanuelle, Stahl, Daniel, Trotta, Antonella and Shergill, Sukhwinder 2022. Cognitive bias modification for paranoia (CBM-pa): a randomised controlled feasibility study in patients with distressing paranoid beliefs. Psychological Medicine. https://doi.org/10.1017/S0033291722001520
The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin
Shergill, S., Rebekah Wigton, Derek K. Tracy, Tess M. Verneuil, Michaela Johns, Thomas White, Panayiota G. Michalopoulou, Bruno Averbeck and Sukhwinder Shergill 2022. The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin. Schizophrenia Research: Cognition. 27. https://doi.org/10.1016/j.scog.2021.100221
Stimulating learning: A functional MRI and behavioral investigation of the effects of transcranial direct current stimulation on stochastic learning in schizophrenia
Natasza D. Orlov, Syed Ali Muqtadir, Hooman Oroojeni, Bruno Averbeck, John Rothwell and Sukhi S. Shergill 2022. Stimulating learning: A functional MRI and behavioral investigation of the effects of transcranial direct current stimulation on stochastic learning in schizophrenia. Psychiatry Research. 317, p. 114908. https://doi.org/10.1016/j.psychres.2022.114908
A novel virtual reality assessment of functional cognition: Validation study
Lilla Alexandra Porffy, Mitul A Mehta, Joel Patchit, Celia Boussebaa, Jack Brett, Teresa D’Oliveira, Elias Mouchlianitis and Sukhi Shergill. 2022. A novel virtual reality assessment of functional cognition: Validation study. Journal of Medical Internet Research. 24 (1), p. e27641. https://doi.org/10.2196/27641
Relaxation of the criteria for entry to the UK Clozapine Central Non-Rechallenge Database: a modelling study
Ebenezer Oloyede, Eromona Whiskey, Cecilia Casetta, Olubanke Dzahini, Danielle Dunnett, Shreyans Gandhi, Prof Fiona Gaughran, Prof Sukhi Shergill, Prof Philip McGuire, Prof James H MacCabe and Prof David Taylor 2022. Relaxation of the criteria for entry to the UK Clozapine Central Non-Rechallenge Database: a modelling study. The Lancet: Psychiatry. 9 (8), pp. 636-644. https://doi.org/10.1016/S2215-0366(22)00188-2
VStore: Feasibility and acceptability of a novel virtual reality functional cognition task
Lilla A. Porffy, Mitul A. Mehta, Elias Mouchlianitis and Sukhi S. Shergill 2022. VStore: Feasibility and acceptability of a novel virtual reality functional cognition task. Frontiers in Virtual Reality.
Alpha3/alpha2 power ratios relate to performance on a virtual reality shopping task in ageing adults
Patchitt, Joel, Porffy, Lilla A., Whomersley, Gabriella, Szentgyorgyi, Timea, Brett, Jack, Mouchlianitis, Elias, Mehta, Mitul A., Nottage, Judith F. and Shergill, Sukhi S. 2022. Alpha3/alpha2 power ratios relate to performance on a virtual reality shopping task in ageing adults. Frontiers in Aging Neuroscience. 14, p. 876832. https://doi.org/10.3389/fnagi.2022.876832
The influence of trial-by-trial feedback on trust in health, first-episode and chronic psychosis
Lemmers-Jansen, I., Wichmann, Rune J., Perizonius, Sophie and Shergill, Sukhi S. 2022. The influence of trial-by-trial feedback on trust in health, first-episode and chronic psychosis. Games. 13 (5), p. e59. https://doi.org/10.3390/g13050059
Vortioxetine as adjunctive therapy in the treatment of schizophrenia
Redaelli, Sofia, Porffy, Lilla, Oloyede, Ebenezer, Dzahini, O., Lewis, Gabriella, Lobo, Maria, Whiskey, E. and Shergill, Sukhi S. 2022. Vortioxetine as adjunctive therapy in the treatment of schizophrenia. Therapeutic Advances in Psychopharmacology. 12, p. 204512532211100. https://doi.org/10.1177/20451253221110014
The role of cognitive control in the positive symptoms of psychosis
Horne, Charlotte M., Sahni, Angad, Pang, Sze W., Vanes, Lucy D., Szentgyorgyi, Timea, Averbeck, Bruno, Moran, Rosalyn J. and Shergill, Sukhwinder S. 2022. The role of cognitive control in the positive symptoms of psychosis. NeuroImage. Clinical. 34, p. 103004. https://doi.org/S2213-1582(22)00069-9
Direct eye gaze enhances the ventriloquism effect
Lavan, N., Chan, Wing Yue, Zhuang, Yongping, Mareschal, Isabelle and Shergill, Sukhwinder S. 2022. Direct eye gaze enhances the ventriloquism effect. Attention, Perception & Psychophysics. https://doi.org/10.3758/s13414-022-02468-5
Preliminary evidence for the phosphodiesterase type-4 inhibitor, roflumilast, in ameliorating cognitive flexibility deficits in patients with schizophrenia
Nicholas R Livingston, Peter CT Hawkins, James Gilleen, Rong Ye, Lorena Valdearenas, Sukhi Shergill and Mitul A Mehta 2021. Preliminary evidence for the phosphodiesterase type-4 inhibitor, roflumilast, in ameliorating cognitive flexibility deficits in patients with schizophrenia. Journal of Psychopharmacology. 35 (9). https://doi.org/10.1177/02698811211000778
Contextual perception under active inference
Berk Mirza, M., Cullen, M., Parr, T., Shergill, S. and Moran, R. 2021. Contextual perception under active inference. Scientific Reports. 11 (16223). https://doi.org/s41598-021-95510-9
Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations
Shergill, S., Amir Krivoy, Eromona Whiskey, Henrietta Webb-Wilson, Dan Joyce, Derek K. Tracy, Fiona Gaughran, James H. MacCabe and Sukhwinder S. Shergill 2021. Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations. Therapeutic Advances in Psychopharmacology. 11. https://doi.org/10.1177/20451253211037179
New approaches to antipsychotic medication adherence – safety, tolerability and acceptability
Taub, Sharon, Krivoy, Amir, Whiskey, Eromona and Shergill, Sukhi S. 2021. New approaches to antipsychotic medication adherence – safety, tolerability and acceptability. Expert Opinion on Drug Safety. 21 (4), pp. 517-524. https://doi.org/10.1080/14740338.2021.1983540