Exploring functional connectivity in clinical and data-driven groups of preterm and term adults
Journal article
Hadaya, L., Váša, František, Dimitrakopoulou, Konstantina, Saqi, Mansoor, Shergill, S., Edwards, A., Batalle, D., Leech, Robert and Nosarti, C. 2025. Exploring functional connectivity in clinical and data-driven groups of preterm and term adults. Brain Communications. 7 (2), p. fcaf074. https://doi.org/10.1093/braincomms/fcaf074
| Authors | Hadaya, L., Váša, František, Dimitrakopoulou, Konstantina, Saqi, Mansoor, Shergill, S., Edwards, A., Batalle, D., Leech, Robert and Nosarti, C. |
|---|---|
| Abstract | Adults born very preterm (i.e. at n = 156, 46% female). Age, sex, socio-economic status and in-scanner head motion were used as confounders in all analyses. Post hoc two-way group interactions between clinical birth status and behavioural data-driven subgrouping classification labels explored whether functional connectivity differences between very preterm and full-term adults varied according to distinct behavioural outcomes. Very preterm compared with full-term adults had poorer scores in selective measures of cognitive and socio-emotional processing and displayed complex patterns of hyper- and hypo-connectivity in sub-sections of the default mode, visual and ventral attention networks. Stratifying the study participants in terms of their behavioural profiles (irrespective of birth status) identified two data-driven subgroups: an 'At-Risk' subgroup, characterized by increased cognitive, mental health and socio-emotional difficulties, displaying hypo-connectivity anchored in frontal opercular and insular regions, relative to a 'Resilient' subgroup with more favourable outcomes. No significant interaction was noted between clinical birth status and behavioural data-driven subgrouping classification labels in terms of functional connectivity. Functional connectivity differentiating between very preterm and full-term adults was dissimilar to functional connectivity differentiating between the data-driven behavioural subgroups. We speculate that functional connectivity alterations observed in very preterm relative to full-term adults may confer both risk and resilience to developing behavioural sequelae associated with very preterm birth, while the localized functional connectivity alterations seen in the 'At-Risk' subgroup relative to the 'Resilient' subgroup may underlie less favourable behavioural outcomes in adulthood, irrespective of birth status. |
| Keywords | Behaviour; Clustering; Preterm birth; Resting state functional MRI |
| Year | 2025 |
| Journal | Brain Communications |
| Journal citation | 7 (2), p. fcaf074 |
| Publisher | Oxford University Press |
| ISSN | 2632-1297 |
| Digital Object Identifier (DOI) | https://doi.org/10.1093/braincomms/fcaf074 |
| Official URL | https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcaf074/8016394 |
| Funder | Institute of Psychiatry, Psychology and Neuroscience |
| King’s College Hospital NHS Foundation Trust | |
| Maudsley NHS Foundation Trust | |
| National Institute for Health Research (NIHR) | |
| Medical Research Council | |
| King's College London | |
| NIHR Comprehensive Biomedical Research Centre | |
| Centre for Medical Engineering at Kings College London | |
| MRC strategic | |
| Engineering and Physical Sciences Research Council | |
| Mental Health Biomedical Research Centre | |
| Publication dates | |
| Online | 17 Feb 2025 |
| 01 Jan 2025 | |
| Publication process dates | |
| Accepted | 13 Feb 2025 |
| Deposited | 26 Feb 2025 |
| Accepted author manuscript | File Access Level Restricted |
| Publisher's version | License File Access Level Open |
| Output status | Published |
| Additional information | Publications router. |
Permalink -
https://repository.canterbury.ac.uk/item/9q6vw/exploring-functional-connectivity-in-clinical-and-data-driven-groups-of-preterm-and-term-adults
Download files
29
total views2
total downloads3
views this month0
downloads this month