Statins Reverse Postpartum Cardiovascular Dysfunction in a Rat Model of Preeclampsia
Journal article
Kräker, Kristin, O’Driscoll, Jamie M., Schütte, Till, Herse, Florian, Patey, Olga, Golic, Michaela, Geisberger, Sabrina, Verlohren, Stefan, Birukov, Anna, Heuser, Arnd, Müller, Dominik N., Thilaganathan, Basky, Dechend, Ralf and Haase, Nadine 2019. Statins Reverse Postpartum Cardiovascular Dysfunction in a Rat Model of Preeclampsia. Hypertension. 75 (1), pp. 202-210. https://doi.org/10.1161/hypertensionaha.119.13219
Authors | Kräker, Kristin, O’Driscoll, Jamie M., Schütte, Till, Herse, Florian, Patey, Olga, Golic, Michaela, Geisberger, Sabrina, Verlohren, Stefan, Birukov, Anna, Heuser, Arnd, Müller, Dominik N., Thilaganathan, Basky, Dechend, Ralf and Haase, Nadine |
---|---|
Abstract | Preeclampsia is associated with increased cardiovascular long-term risk; however, the underlying functional and structural mechanisms are unknown. We investigated maternal cardiac alterations after preeclampsia. Female rats harboring the human angiotensinogen gene [TGR(hAogen)L1623] develop a preeclamptic phenotype with hypertension and albuminuria during pregnancy when mated with male rats bearing the human renin gene [TGR(hRen)L10J] but behave physiologically normal before and after pregnancy. Furthermore, rats were treated with pravastatin. We tested the hypothesis that statins are a potential therapeutic intervention to reduce cardiovascular alterations due to simulated preeclamptic pregnancy. Although hypertension persists for only 8 days in pregnancy, former preeclampsia rats exhibit significant cardiac hypertrophy 28 days after pregnancy observed in both speckle tracking echocardiography and histological staining. In addition, fibrosis and capillary rarefaction was evident. Pravastatin treatment ameliorated the remodeling and improved cardiac output postpartum. Preeclamptic pregnancy induces irreversible structural changes of cardiac hypertrophy and fibrosis, which can be moderated by pravastatin treatment. This pathological cardiac remodeling might be involved in increased cardiovascular risk in later life. |
Keywords | Internal Medicine |
Year | 2019 |
Journal | Hypertension |
Journal citation | 75 (1), pp. 202-210 |
Publisher | Ovid Technologies (Wolters Kluwer Health) |
ISSN | 0194-911X |
1524-4563 | |
Digital Object Identifier (DOI) | https://doi.org/10.1161/hypertensionaha.119.13219 |
Official URL | https://doi.org/10.1161/HYPERTENSIONAHA.119.13219 |
Publication dates | |
2020 | |
Publication process dates | |
Accepted | 02 Dec 2019 |
Deposited | 18 Dec 2019 |
Accepted author manuscript | |
Output status | Published |
Permalink -
https://repository.canterbury.ac.uk/item/8q219/statins-reverse-postpartum-cardiovascular-dysfunction-in-a-rat-model-of-preeclampsia
Download files
134
total views103
total downloads0
views this month2
downloads this month