Exercise training in heart failure with preserved and reduced ejection fraction: A systematic review and meta-analysis

Journal article

Edwards, J. and O'Driscoll, J. 2022. Exercise training in heart failure with preserved and reduced ejection fraction: A systematic review and meta-analysis. Sports Medicine - Open. 8 (1), p. 76. https://doi.org/10.1186/s40798-022-00464-5
AuthorsEdwards, J. and O'Driscoll, J.
Abstract

Background
While exercise training (ET) is an established tool in heart failure (HF), no research to date has analysed the efficacy of ET in both preserved (HFpEF) and reduced (HFrEF) ejection fraction phenotypes across the same clinically important parameters.

Methods
A comprehensive systematic search was performed to identify trials published between 1990 and May 2021. Controlled trials of adults reporting pre- and post-ET peak VO2, 6-min walk distance (6MWD), Minnesota Living with Heart Failure Questionnaire (MLHFQ), Kansas City Cardiomyopathy Questionnaire (KCCQ) and left ventricular ejection fraction (LVEF) were considered. Parameters of cardiac diastolic function, brain natriuretic peptides (BNP)/N-terminal prohormone of BNP (NTproBNP) and follow-up hospitalisation and mortality data were also analysed.

Results
Ninety-three studies (11 HFpEF and 82 HFrEF) were included in the final analysis, with a pooled sample size of 11,081 participants. HFpEF analysis demonstrated significant improvements in peak VO2 (weighted mean difference: 2.333 ml·min-1·kg-1, Pfixed < 0.001), 6MWD (WMD: 35.396 m, Pfixed < 0.001), MLHFQ (WMD: − 10.932, Prandom < 0.001), KCCQ (WMD: 3.709, Pfixed = 0.037) and E/e′ (WMD: − 1.709, [95% CI] = − 2.91–0.51, Prandom = 0.005). HFrEF analysis demonstrated significant improvements in peak VO2 (WMD: 3.050 ml·min-1·kg-1, Prandom < 0.001), 6MWD (WMD: 37.299 m, Prandom < 0.001), MLHFQ (WMD: − 10.932, Prandom < 0.001), LVEF (WMD: 2.677%, Prandom = 0.002) and BNP/NTproBNP (SMD: − 1.349, Prandom < 0.001). Outcome analysis was only performed in HFrEF, which found no significant changes in hospitalisation, all-cause mortality or composite end-points.

Conclusion
ET significantly improves exercise capacity and quality of life in both HFpEF and HFrEF patients. In HFpEF patients, ET significantly improved an important index of diastolic function, with significant improvements in LVEF and NTproBNP/BNP seen in HFrEF patients only. Such benefits did not translate into significantly reduced hospitalisation or mortality after short-term follow-up.

KeywordsHeart Failure; Exercise Training; Hfpef; Hfref
Year2022
JournalSports Medicine - Open
Journal citation8 (1), p. 76
PublisherSpringer
ISSN2198-9761
2199-1170
Digital Object Identifier (DOI)https://doi.org/10.1186/s40798-022-00464-5
Official URLhttps://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-022-00464-5
Publication dates
Online08 Jun 2022
Print01 Jun 2022
Publication process dates
Accepted13 May 2022
Deposited16 Jun 2022
Publisher's version
License
File Access Level
Open
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/91398/exercise-training-in-heart-failure-with-preserved-and-reduced-ejection-fraction-a-systematic-review-and-meta-analysis

Download files

Publisher's version
Sports Medicine Open HFrEF and HFpEF.pdf
License: CC BY 4.0
File access level: Open

  • 137
    total views
  • 35
    total downloads
  • 5
    views this month
  • 0
    downloads this month

Export as

Related outputs

First trimester pre‐eclampsia screening and maternal left ventricular geometry
Ridder, A., O'Driscoll, J., Khalil, A. and Thilaganathan, B. 2024. First trimester pre‐eclampsia screening and maternal left ventricular geometry. Ultrasound in Obstetrics & Gynecology. 64 (S1), pp. 1-1. https://doi.org/10.1002/uog.27721
Experiences, acceptability and feasibility of an isometric exercise intervention for stage 1 hypertension: embedded qualitative study in a randomised controlled feasibility trial.
Rees-Roberts, M., Borthwick, Rachel, Santer, Ellie, Darby, John, West, Alan, O'Driscoll, Jamie M, Pellatt-Higgins, Tracy, Gousia, Katerina, Short, Vanessa, Doulton, Tim, Wiles, Jim, Farmer, Chris and MacInnes, Douglas 2024. Experiences, acceptability and feasibility of an isometric exercise intervention for stage 1 hypertension: embedded qualitative study in a randomised controlled feasibility trial. Pilot and Feasibility Studies. 10 (1), p. 113. https://doi.org/10.1186/s40814-024-01539-8
An alternative protocol to improve accessibility to isometric exercise training to treat uncomplicated hypertension
Wiles, Jonathan, Rees-roberts, Melanie, Santer, Ellie, Lea, John, O’Driscoll, Jamie, Macinnes, Douglas, Pellatt-higgins, Tracey, Mills, Ashley, Gousia, Katerina, West, Alan, Darby, John, Borthwick, Rachel, Doulton, Tim, Swift, Pauline and Farmer, Chris 2024. An alternative protocol to improve accessibility to isometric exercise training to treat uncomplicated hypertension . Journal of Hypertension. 42 (Suppl 1), pp. e218-e219. https://doi.org/10.1097/01.hjh.0001021680.26786.d4
Left atrial mechanics following preeclamptic pregnancy
O'Driscoll, J., McCarthy, F., Giorgione, V., Jalaludeen, Navazh, Seed, P., Gill, C., Sparkes, J., Poston, L., Marber, Mike, Shennan, A., Chappell, L., Thilaganathan, B. and Leeson, P. 2024. Left atrial mechanics following preeclamptic pregnancy. Hypertension. https://doi.org/10.1161/HYPERTENSIONAHA.123.22577
International criteria for reporting study quality for sudden cardiac arrest/death tool
Edwards, J., Compton, C., Chatrath, Nikhil, Petek, Bradley J, Baggish, A., Börjesson, M., Corrado, D., Drezner, J., Gati, Sabiha, Gray, B., Kim, J., La Gerche, A., Malhotra, A., Marijon, E., Papadakis, M., Pelliccia, A., Phelan, Dermot, Semsarian, C., Sharma, S., O'Driscoll, J., Sharma, Rajan and Harmon, K. 2024. International criteria for reporting study quality for sudden cardiac arrest/death tool. Journal of the American Heart Association. 13 (11), p. e033723. https://doi.org/10.1161/JAHA.123.033723
Isometric exercise training and arterial hypertension: an updated review
Edwards, J., Coleman, D., Ritti-Dias, R.M., Farah, B.Q., Stensel, D.J., Lucas, S.J.E., Millar, P.J., Gordon, B.D.H., Cornelissen, V., Smart, N.A., Carlson, D.J., McGowan, C., Swaine, I., Pescatello, L.S., Howden, R., Bruce-Low, S., Farmer, C., Leeson, P., Sharma, R. and O'Driscoll, J. 2024. Isometric exercise training and arterial hypertension: an updated review. Sports Medicine.
Differences in biomechanical determinants of ACL injury risk in Change of Direction tasks between males and females: A systematic review and meta-analysis
Donelon, Thomas A, Edwards, Jamie, Brown, Mathew, Jones, Paul A, O'Driscoll, Jamie and Dos'Santos, T. 2024. Differences in biomechanical determinants of ACL injury risk in Change of Direction tasks between males and females: A systematic review and meta-analysis. Sports Medicine - Open. 10 (1), p. 29. https://doi.org/10.1186/s40798-024-00701-z
Characteristics associated with responsiveness to isometric handgrip training in medicated hypertensive patients: secondary data analysis.
Farah, Breno Q, Forjaz, Claudia L M, O'Driscoll, Jamie M, Millar, Philip J, Oliveira, Marcelo S, Fecchio, Rafael, Kanegusuku, Helcio, Sousa, Julio C S, Correia, Marilia A and Ritti-Dias, Raphael M 2024. Characteristics associated with responsiveness to isometric handgrip training in medicated hypertensive patients: secondary data analysis. Journal of Hypertension. https://doi.org/10.1097/HJH.0000000000003749
Acute effects of breaking up sitting time with isometric wall squat exercise on vascular function and blood pressure in sedentary adults: Randomized crossover trial
Silva, Jéssika K. T. N. F., Menêses, Annelise L., Silva, Gustavo O., O'Driscoll, Jamie M., Ritti-Dias, Raphael M., Correia, Marilia A. and Farah, B. 2024. Acute effects of breaking up sitting time with isometric wall squat exercise on vascular function and blood pressure in sedentary adults: Randomized crossover trial. Journal of Cardiopulmonary Rehabilitation and Prevention. https://doi.org/10.1097/HCR.0000000000000877
The acute impact of endurance exercise on right ventricular structure and function: A systematic review and meta-analysis
Ramcharan, Tristan, Edwards, Jamie, O’Driscoll, Jamie and Papadakis, Michael 2024. The acute impact of endurance exercise on right ventricular structure and function: A systematic review and meta-analysis. Cardiac Electrophysiology Clinics. 16 (1), pp. 25-34. https://doi.org/10.1016/j.ccep.2023.09.005
The effects of high intensity interval training on quality of life: a systematic review and meta-analysis
Griffiths, M., Edwards, J., McNamara, J., Galbraith, A., Bruce-Low, S. and O'Driscoll, J. 2024. The effects of high intensity interval training on quality of life: a systematic review and meta-analysis. Journal of Public Health. https://doi.org/10.1007/s10389-024-02192-4
Artificial intelligence calculated global longitudinal strain and left ventricular ejection fraction predicts cardiac events and all‐cause mortality in patients with chest pain
O'Driscoll, J., Tuttolomondo, Domenico and Gaibazzi, Nicola 2023. Artificial intelligence calculated global longitudinal strain and left ventricular ejection fraction predicts cardiac events and all‐cause mortality in patients with chest pain. Echocardiography. 40 (12), pp. 1356-1364. https://doi.org/10.1111/echo.15714
Automated echocardiographic detection of heart failure with preserved ejection fraction using artificial intelligence
Akerman, A.P., Porumb, M., Scott, C.G., Beqiri, A., Chartsiad, A., Ryu, A.J., Hawkes, W., Huntley, G.D., Arystan, A.Z., Kane, G.C., Pislaru, S.V., Lopez-Jimenez, F., Sarwar, R., O'Driscoll, J., Leeson, P., Upton, R., Woodward, G. and Pellikka, P.A. 2023. Automated echocardiographic detection of heart failure with preserved ejection fraction using artificial intelligence. JACC Advances - Journal of the American College of Cardiology. 2 (6), p. 100452. https://doi.org/10.1016/j.jacadv.2023.100452
Aortic regurgitation in athletes: The challenges of echocardiographic interpretation
Chatrath, N., O'Driscoll, J., Sharma, S. and Papadakis, M. 2023. Aortic regurgitation in athletes: The challenges of echocardiographic interpretation. Echo Research and Practice. 10 (20).
Angiogenic markers and maternal echocardiographic indices in women with hypertensive disorders of pregnancy.
Giorgione, G., Di Fabrizio, C, Giallongo, E, Khalil, A., O'Driscoll, J, Whitley, G, Kennedy, G, Murdoch, C E and Thinagalathan, B. 2023. Angiogenic markers and maternal echocardiographic indices in women with hypertensive disorders of pregnancy. Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.27474
Infographic. Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials.
Edwards, J., Deenmamode, Algis H P, Griffiths, Megan, Arnold, Oliver, Cooper, Nicola J., Wiles, Jonathan D. and O'Driscoll, J. 2023. Infographic. Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine. 2023 (57), pp. 1335-1336. https://doi.org/10.1136/bjsports-2023-107513
Routine first-trimester pre-eclampsia screening and maternal left ventricular geometry.
Ridder, A., O'Driscoll, J, Khalil, A. and Thilaganathan, B. 2023. Routine first-trimester pre-eclampsia screening and maternal left ventricular geometry. Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.26306
Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials
Edwards, J., Deenmamode, A.H.P., Griffiths, M., Arnold, O., Cooper, N.J., Wiles, J. and O'Driscoll, J. 2023. Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine. https://doi.org/10.1136/bjsports-2022-106503
Real world hospital costs following stress echocardiography in the UK: a costing study from the EVAREST/BSE-NSTEP multi-entre study.
Johnson, Casey L, Woodward, William, McCourt, Annabelle, Dockerill, Cameron, Krasner, Samuel, Monaghan, Mark, Senior, Roxy, Augustine, Daniel X, Paton, Maria, O'Driscoll, Jamie, Oxborough, David, Pearce, Keith, Robinson, Shaun, Willis, James, Sharma, Rajan, Tsiachristas, Apostolos, Leeson, Paul and EVAREST/BSE-NSTEP Investigators 2023. Real world hospital costs following stress echocardiography in the UK: a costing study from the EVAREST/BSE-NSTEP multi-entre study. Echo Research and Practice. 10 (1), p. 8. https://doi.org/10.1186/s44156-023-00020-1
High intensity interval training and cardiometabolic health in the general population: A systematic review and meta-analysis of randomised controlled trials
Edwards, J., Griffiths, M, Deenmamode, A.H.P and O'Driscoll, J. 2023. High intensity interval training and cardiometabolic health in the general population: A systematic review and meta-analysis of randomised controlled trials. Sports Medicine. https://doi.org/10.1007/s40279-023-01863-8
The effect of isometric exercise training on arterial stiffness: a randomised crossover controlled study
Edwards, J., Jalaludeen, N, Beqiri, A, Wiles, J., Sharma, R and O'Driscoll, J. 2023. The effect of isometric exercise training on arterial stiffness: a randomised crossover controlled study. Physiological Reports. 11 (10), p. e15690. https://doi.org/10.14814/phy2.15690
Delivering clinical studies of exercise in the COVID-19 pandemic: challenges and adaptations using a feasibility trial of isometric exercise to treat hypertension as an exemplar.
Farmer, Chris, Santer, Ellie, West, Alan, Darby, John, Rees-Roberts, Melanie, Doulton, Timothy, MacInnes, D., O'Driscoll, J., Borthwick, Rachel, Pellatt-Higgins, Tracy, Gousia, Katerina, Short, Vanessa, Swift, Pauline A and Wiles, J. 2023. Delivering clinical studies of exercise in the COVID-19 pandemic: challenges and adaptations using a feasibility trial of isometric exercise to treat hypertension as an exemplar. BMJ Open. 13 (3), p. e068204. https://doi.org/10.1136/bmjopen-2022-068204
Postpartum cardiovascular function in patients with hypertensive disorders of pregnancy: A longitudinal study
Giorgione, Veronica, Khalil, Asma, O'Driscoll, Jamie and Thilaganathan, Basky 2023. Postpartum cardiovascular function in patients with hypertensive disorders of pregnancy: A longitudinal study. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/j.ajog.2023.03.019
The value of cardiopulmonary exercise testing and stress echocardiography in the prediction of all-cause mortality in adults with end stage renal disease
O'Driscoll, J., Edwards, J., Greenhough, E., Smith, E., May, M., Gupta, S., Marciniak, A and Sharma, R. 2023. The value of cardiopulmonary exercise testing and stress echocardiography in the prediction of all-cause mortality in adults with end stage renal disease. European Journal of Sport Science.
Artificial intelligence based left ventricular ejection fraction and global longitudinal strain in cardiac amyloidosis
Cotella, J., Slivnick, Jeremy A., Sanderson, Emily, Singulane, Cristiane, O'Driscoll, Jamie, Asch, Federico M., Addetia, K., Woodward, Gary and Lang, Roberto M. 2023. Artificial intelligence based left ventricular ejection fraction and global longitudinal strain in cardiac amyloidosis. Echocardiography. 40 (3), pp. 188-195. https://doi.org/10.1111/echo.15516
Exercise mode in heart failure: A systematic review and meta-analysis
Edwards, J., Shanmugam, Nesan, Ray, Robin, Jouhra, Fadi, Mancio, Jennifer, Wiles, J., Marciniak, Anna, Sharma, Rajan and O'Driscoll, J. 2023. Exercise mode in heart failure: A systematic review and meta-analysis. Sports Medicine - Open. 9 (1), p. 3. https://doi.org/10.1186/s40798-022-00549-1
Left ventricular assessment with artificial intelligence increases the diagnostic accuracy of stress echocardiography.
O'Driscoll, Jamie M, Hawkes, William, Beqiri, Arian, Mumith, Angela, Parker, Andrew, Upton, Ross, McCourt, Annabelle, Woodward, W., Dockerill, Cameron, Sabharwal, N., Kardos, Attila, Augustine, Daniel X, Balkhausen, Katrin, Chandrasekaran, B., Firoozan, Soroosh, Marciniak, Anna, Heitner, Stephen, Yadava, Mrinal, Kaul, Sanjiv, Sarwar, Rizwan, Sharma, Rajan, Woodward, Gary and Leeson, P. 2022. Left ventricular assessment with artificial intelligence increases the diagnostic accuracy of stress echocardiography. European Heart Journal Open. 2 (5), p. oeac059. https://doi.org/10.1093/ehjopen/oeac059
Planned delivery for pre-eclampsia between 34 and 37 weeks of gestation: the PHOENIX RCT.
Chappell, L., Brocklehurst, P., Green, M., Hardy, P., Hunter, R., Beardmore-Gray, A., Bowler, U., Brockbank, A., Chiocchia, V., Cox, A., Duhig, K., Fleminger, J., Gill, C., Greenland, M., Hendy, E., Kennedy, A., Leeson, P., Linsell, L., McCarthy, F., O'Driscoll, J., Placzek, A., Poston, L., Robson, S., Rushby, P., Sandall, J., Scholtz, L., Seed, P., Sparkes, J., Stanbury, K., Tohill, S., Thilaganathan, B., Townend, J., Juszczak, E., Marlow, N. and Shennan, A. 2022. Planned delivery for pre-eclampsia between 34 and 37 weeks of gestation: the PHOENIX RCT. Health Technology Assessment. https://doi.org/10.3310/CWWH0622
Both sides of a coin: Having open heart surgery while researching in cardiology
Edwards, Jamie J 2022. Both sides of a coin: Having open heart surgery while researching in cardiology. JACC. Case reports. 4 (22), pp. 1556-1558. https://doi.org/10.1016/j.jaccas.2022.08.041
Peripartum screening for postpartum hypertension in women with hypertensive disorders of pregnancy
Giorgione, Veronica, Khalil, Asma, O'Driscoll, Jamie and Thilaganathan, Basky 2022. Peripartum screening for postpartum hypertension in women with hypertensive disorders of pregnancy. Journal of the American College of Cardiology. 80 (15), pp. 1465-1476. https://doi.org/S0735-1097(22)06532-9
Myocardial performance index as a measure of global left ventricular function improves following isometric exercise training in hypertensive patients
Edwards, J., Jalaludeen, N., Taylor, K., Wiles, J. and O'Driscoll, J. 2022. Myocardial performance index as a measure of global left ventricular function improves following isometric exercise training in hypertensive patients. Hypertension Research. https://doi.org/10.1038/s41440-022-01019-7
The acute effect of endurance exercise on right ventricular structure, function and mechanics: A systematic review and meta-analysis
Ramcharan, T., Edwards, J., O'Driscoll, J. and Papadakis, M. 2022. The acute effect of endurance exercise on right ventricular structure, function and mechanics: A systematic review and meta-analysis. Cardiology Clinics. 41 (1), pp. 25-34. https://doi.org/10.1016/j.ccl.2022.08.004
One year of isometric exercise training for blood pressure management in men: a prospective randomized controlled study
O’Driscoll, Jamie M., Edwards, Jamie J., Coleman, Damian A., Taylor, Katrina A., Sharma, Rajan and Wiles, Jonathan D. 2022. One year of isometric exercise training for blood pressure management in men: a prospective randomized controlled study. Journal of Hypertension. 40 (12), pp. 2406-2412. https://doi.org/10.1097/hjh.0000000000003269
Mechanisms for blood pressure reduction following isometric exercise training: A systematic review and meta-analysis
Edwards, J., Wiles, Jonathan and O'Driscoll, Jamie J. 2022. Mechanisms for blood pressure reduction following isometric exercise training: A systematic review and meta-analysis. Journal of Hypertension. https://doi.org/10.1097/HJH.0000000000003261
Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham‐controlled study
Decaux, A., Edwards, J., Swift, Harry T., Hurst, Philip, Hopkins, Jordan, Wiles, Jonathan D. and O'Driscoll, J. 2022. Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham‐controlled study. Physiological Reports. 10 (2). https://doi.org/10.14814/phy2.15112
Maternal echocardiographic changes in twin pregnancies with and without pre‐eclampsia
Giorgione, V., Melchiorre, K., O’Driscoll, J., Khalil, A., Sharma, R. and Thilaganathan, B. 2022. Maternal echocardiographic changes in twin pregnancies with and without pre‐eclampsia. Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.24852
Undiagnosed chronic obstructive pulmonary disease is highly prevalent in patients referred for dobutamine stress echocardiography with shortness of breath
O'Driscoll, Jamie M, Giannoglou, Dimitrios, Bashar, Ibrahim, Kipourou, Konstantina, Alati, Emanuela, Madden, Brendan, Marciniak, Anna and Sharma, R. 2022. Undiagnosed chronic obstructive pulmonary disease is highly prevalent in patients referred for dobutamine stress echocardiography with shortness of breath. Lung. 200 (1), pp. 41-48. https://doi.org/10.1007/s00408-022-00512-7
Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients
O'Driscoll, J., Edwards, J., Wiles, J., Taylor, K., Leeson, P. and Sharma, R. 2022. Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients. European Journal of Applied Physiology. https://doi.org/10.1007/s00421-021-04882-3
Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham-controlled study
De Caux, A., Edwards, J., Swift, H., Hurst, P., Wiles, J. and O'Driscoll, J. 2022. Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham-controlled study. Physiological Reports. 10 (2), p. e15112.
Valvular heart disease in patients with chronic kidney disease
Kipourou, Konstantina, O'Driscoll, Jamie M and Sharma, Rajan 2022. Valvular heart disease in patients with chronic kidney disease. European cardiology. 17, p. e02. https://doi.org/10.15420/ecr.2021.25
Peripartum echocardiographic changes in women with hypertensive disorders of pregnancy
Giorgione, V., O'Driscoll, J., Coutinho, C., Di Fabrizio, C., Sharma, R., Khalil, A. and Thilaganathan, B. 2022. Peripartum echocardiographic changes in women with hypertensive disorders of pregnancy. Ultrasound in Obstetrics & Gynecology. 59 (3), pp. 365-370. https://doi.org/10.1002/uog.23745
Isometric exercise versus high-intensity interval training for the management of blood pressure: a systematic review and meta-analysis.
Edwards, J., De Caux, Anthony, Donaldson, James, Wiles, J. and O'Driscoll, J. 2021. Isometric exercise versus high-intensity interval training for the management of blood pressure: a systematic review and meta-analysis. British Journal of Sports Medicine. https://doi.org/bjsports-2021-104642
Convergent validity of ratings of perceived exertion during resistance exercise in healthy participants: A systematic review and meta-analysis
Lea, J., O'Driscoll, J., Hulbert, S., Scales, J. and Wiles, J. 2021. Convergent validity of ratings of perceived exertion during resistance exercise in healthy participants: A systematic review and meta-analysis. Sports Medicine - Open. https://doi.org/10.1186/s40798-021-00386-8
Myocardial mechanics in hypertensive disorders of pregnancy: a systematic review and meta-analysis
O'Driscoll, J., Giorgione, V., Edwards, J., Wiles, Jonathan D., Sharma, Rajan and Thilaganathan, B. 2021. Myocardial mechanics in hypertensive disorders of pregnancy: a systematic review and meta-analysis. Hypertension. 79 (2), pp. 391-398. https://doi.org/10.1161/hypertensionaha.121.18123
Left ventricular mechanical, cardiac autonomic and metabolic responses to a single session of high intensity interval training.
Edwards, Jamie, Wiles, Jonathan D., Vadaszy, Noemi, Taylor, Katrina A. and O'Driscoll, Jamie 2021. Left ventricular mechanical, cardiac autonomic and metabolic responses to a single session of high intensity interval training. European Journal of Applied Physiology. https://doi.org/10.1007/s00421-021-04840-z
Automated echocardiographic detection of severe coronary artery disease using artificial intelligence
Upton, Ross, Mumith, Angela, Beqiri, Arian, Parker, Andrew, Hawkes, William, Gao, Shan, Porumb, Mihaela, Sarwar, Rizwan, Marques, Patricia, Markham, Deborah, Kenworthy, Jake, O'Driscoll, Jamie M, Hassanali, Neelam, Groves, Kate, Dockerill, Cameron, Woodward, William, Alsharqi, Maryam, McCourt, Annabelle, Wilkes, Edmund H, Heitner, Stephen B, Yadava, Mrinal, Stojanovski, David, Lamata, Pablo, Woodward, Gary and Leeson, Paul 2021. Automated echocardiographic detection of severe coronary artery disease using artificial intelligence. JACC: Cardiovascular Imaging. https://doi.org/S1936-878X(21)00780-4
Feasibility study to assess the delivery of a novel isometric exercise intervention for people with stage 1 hypertension in the NHS: protocol for the IsoFIT-BP study including amendments to mitigate the risk of COVID-19.
Wiles, J., Rees-Roberts, Melanie, O'Driscoll, J., Doulton, Timothy, MacInnes, D., Short, Vanessa, Pellatt-Higgins, Tracy, Saxby, Katie, Gousia, K., West, Alan, Smith, Maggie, Santer, E., Darby, John and Farmer, Chris K 2021. Feasibility study to assess the delivery of a novel isometric exercise intervention for people with stage 1 hypertension in the NHS: protocol for the IsoFIT-BP study including amendments to mitigate the risk of COVID-19. Pilot and Feasibility Studies. 7 (1), p. 192. https://doi.org/10.1186/s40814-021-00925-w
Planned delivery to improve postpartum cardiac function in women with preterm pre-eclampsia: the PHOEBE mechanisms of action study within the PHOENIX RCT
McCarthy, F., O'Driscoll, J., Seed, P., Brockbank, A., Cox, A., Gill, C., Green, M., Marber, M., Poston, L., Placzek, A., Shennan, A., Sparkes, J., Leeson, P., Thilaganathan, B. and Chappell, L. 2021. Planned delivery to improve postpartum cardiac function in women with preterm pre-eclampsia: the PHOEBE mechanisms of action study within the PHOENIX RCT. Efficacy and Mechanism Evaluation. 8 (12), pp. 1-28. https://doi.org/10.3310/eme08120
Multicenter cohort study, with a nested randomized comparison, to examine the cardiovascular impact of preterm preeclampsia
McCarthy, F.P., O'Driscoll, J., Seed, P.T., Placzek, A., Gill, C., Sparkes, J., Poston, L., Marber, M., Shennan, A.H., Thilaganathan, B., Leeson, P. and Chappell, L.C. 2021. Multicenter cohort study, with a nested randomized comparison, to examine the cardiovascular impact of preterm preeclampsia. Hypertension. https://doi.org/10.1161/HYPERTENSIONAHA.121.17171
Risk of atrial fibrillation in athletes: a systematic review and meta-analysis.
Newman, William, Parry-Williams, Gemma, Wiles, Jonathan, Edwards, Jamie, Hulbert, Sabina, Kipourou, Konstantina, Papadakis, Michael, Sharma, Rajan and O'Driscoll, Jamie 2021. Risk of atrial fibrillation in athletes: a systematic review and meta-analysis. British Journal of Sports Medicine. https://doi.org/bjsports-2021-103994
Validity and reliability of RPE as a measure of intensity during isometric wall squat exercise
Lea, J., O'Driscoll, J., Coleman, D. and Wiles, J. 2021. Validity and reliability of RPE as a measure of intensity during isometric wall squat exercise. Journal of Clinical and Translational Research. 7 (2), pp. 248-256. https://doi.org//10.18053/jctres.07.202102.007
Validity and reliability of the ‘Isometric Exercise Scale’ (IES) for measuring ratings of perceived exertion during continuous isometric exercise
Lea, J., O'Driscoll, J., Coleman, D. and Wiles, J. 2021. Validity and reliability of the ‘Isometric Exercise Scale’ (IES) for measuring ratings of perceived exertion during continuous isometric exercise. Scientific Reports. 11 (5334). https://doi.org/10.1038/s41598-021-84803-8
Real-world performance and accuracy of stress echocardiography: the EVAREST observational multi-centre study
Woodward, W., Dockerill, Cameron, McCourt, Annabelle, Upton, Ross, O'Driscoll, Jamie, Balkhausen, Katrin, Chandrasekaran, Badrinathan, Firoozan, Soroosh, Kardos, Attila, Wong, Kenneth, Woodward, Gary, Sarwar, Rizwan, Sabharwal, N., Benedetto, Elena, Spagou, Nancy, Sharma, Rajan, Augustine, Daniel, Tsiachristas, Apostolos, Senior, R., Leeson, P., Boardman, Henry, d’Arcy, Joanna, Abraheem, Abraheem, Banypersad, Sanjay, Boos, Christopher, Bulugahapitiya, Sudantha, Butts, Jeremy, Coles, Duncan, Easaw, Jacob, Hamdan, Haytham, Jamil-Copley, Shahnaz, Kanaganayagam, Gajen, Mwambingu, Tom, Pantazis, Antonis, Papachristidis, Alexandros, Rajani, Ronak, Rasheed, Muhammad Amer, Razvi, Naveed A, Rekhraj, Sushma, Ripley, David P, Rose, Kathleen, Scheuermann-Freestone, Michaela, Schofield, Rebecca and Sultan, Ayyaz 2021. Real-world performance and accuracy of stress echocardiography: the EVAREST observational multi-centre study. European Heart Journal - Cardiovascular Imaging. 23 (5), pp. 689-698. https://doi.org/10.1093/ehjci/jeab092
Continuous cardiac autonomic and haemodynamic responses to isometric exercise in females
O'Driscoll, J., Boucher, C., Vilda, M., Taylor, K. and Wiles, J. 2020. Continuous cardiac autonomic and haemodynamic responses to isometric exercise in females. European Journal of Applied Physiology and Occupational Physiology. https://doi.org/10.1007/s00421-020-04525-z
Ambulatory blood pressure adaptations to high-intensity interval training: a randomized controlled study
Edwards, J., Taylor, K.A., Cottam, C., Jalaludeen, N., Coleman, D.A., Wiles, J.D., Sharma, R. and O'Driscoll, J.M. 2020. Ambulatory blood pressure adaptations to high-intensity interval training: a randomized controlled study. Journal of Hypertension. https://doi.org/10.1097/HJH.0000000000002630
Centre of pressure, vertical ground reaction forces and neuromuscular responses of special-forces soldiers to 43km load carriage in the field
Scales, J., O'Driscoll, J., Coleman, D., Giannoglou, D, Gkougkoulis, I, Ntontis, I, Zisopoulou, C and Brown, M. 2020. Centre of pressure, vertical ground reaction forces and neuromuscular responses of special-forces soldiers to 43km load carriage in the field. Journal of Applied Biomechanics.
Left atrial mechanics and aortic stiffness following high intensity interval training: a randomised controlled study
Jalaludeen, N., Bull, S., Taylor, K. A., Wiles, J., Coleman, D., Mukhtar, O., Cheriyan, J., Wilkinson, I.B., Sharma, R. and O'Driscoll, J. 2020. Left atrial mechanics and aortic stiffness following high intensity interval training: a randomised controlled study. European Journal of Applied Physiology. https://doi.org/10.1007/s00421-020-04416-3
Left atrial mechanics and aortic stiffness following high intensity interval training: a randomised controlled study [Abstract]
Jalaludeen, N., Bull, S., Taylor, K. A., Wiles, J., Coleman, D., Mukhtar, O., Cheriyan, J., Wilkinson, I.B., Sharma, R. and O'Driscoll, J. 2020. Left atrial mechanics and aortic stiffness following high intensity interval training: a randomised controlled study [Abstract]. European Heart Journal - Cardiovascular Imaging. 21 (1). https://doi.org/10.1093/ehjci/jez319.221
Differentiation between athlete’s heart and dilated cardiomyopathy in athletic individuals
Millar, L. M., Fanton, Z., Finnochiaro, G., Sanchez-Fernandez, G., Dhutia, H., Malhotra, A., Merghani, A., Papadakis, M., Behr, E. R., Bunce, N., Oxborough, D., Reed, M., O'Driscoll, J., Tome Esteban, M. T., D'Silva, A., Carr-White, G., Sharma, R. and Sharma, S. 2020. Differentiation between athlete’s heart and dilated cardiomyopathy in athletic individuals. Heart. https://doi.org/10.1136/heartjnl-2019-316147
The impact of demographic, anthropometric and athletic characteristics on left atrial size in athletes.
O'Driscoll, J. and Christou, G. 2020. The impact of demographic, anthropometric and athletic characteristics on left atrial size in athletes. Clinical Cardiology. 43 (8), pp. 834-842. https://doi.org/10.1002/clc.23368
Speckle tracking echocardiography: new ways of translational approaches in preeclampsia to detect cardiovascular dysfunction
Kraker, K., Schutte, T., O'Driscoll, J., Birukov, A., Patey, O., Herse, F., Muller, D.N., Thilaganathan, B., Haase, N. and Dechend, R. 2020. Speckle tracking echocardiography: new ways of translational approaches in preeclampsia to detect cardiovascular dysfunction. International Journal of Molecular Sciences. 21 (3). https://doi.org/10.3390/ijms21031162
Challenge and threat: a critical review of the literature and an alternative conceptualization
Uphill, M., Rossato, C., Swain, J. and O'Driscoll, J. 2019. Challenge and threat: a critical review of the literature and an alternative conceptualization. Frontiers in Psychology. https://doi.org/10.3389/fpsyg.2019.01255
Cardiac structure and function after revascularization versus medical therapy for renal artery stenosis: the ASTRAL heart echocardiographic sub-study
Green, D., Vassallo, D., Handley, K., Ives, N., Wheatley, K., Chrysochou, C., Hegarty, J., Wright, J., Moss, J., Patel, R., Deighan, C., Webster, J., Rowe, P., Carr, S., Cross, J., O'Driscoll, J., Sharma, R., Mark, P. and Kalra, P. 2019. Cardiac structure and function after revascularization versus medical therapy for renal artery stenosis: the ASTRAL heart echocardiographic sub-study. BMC Nephrology. https://doi.org/10.1186/s12882-019-1406-y
Characteristics of torque production of the lower limb are significantly altered after 2 hours of treadmill load carriage
Scales, J., Coleman, D., O'Driscoll, J. and Brown, M. 2018. Characteristics of torque production of the lower limb are significantly altered after 2 hours of treadmill load carriage. Translational Sports Medicine. 2 (1). https://doi.org/10.1002/tsm2.54
The impact of gestational diabetes on maternal cardiac adaptation to pregnancy.
Buddeberg, B.S., Sharma, R., O'Driscoll, J., Kaelin, A., Khalil, A. and Thilaganathan, B. 2019. The impact of gestational diabetes on maternal cardiac adaptation to pregnancy. Ultrasound in Obstetrics and Gynecology. https://doi.org/10.1002/uog.21941
Statins Reverse Postpartum Cardiovascular Dysfunction in a Rat Model of Preeclampsia
Kräker, Kristin, O’Driscoll, Jamie M., Schütte, Till, Herse, Florian, Patey, Olga, Golic, Michaela, Geisberger, Sabrina, Verlohren, Stefan, Birukov, Anna, Heuser, Arnd, Müller, Dominik N., Thilaganathan, Basky, Dechend, Ralf and Haase, Nadine 2019. Statins Reverse Postpartum Cardiovascular Dysfunction in a Rat Model of Preeclampsia. Hypertension. 75 (1), pp. 202-210. https://doi.org/10.1161/hypertensionaha.119.13219
Left ventricular function and cardiac biomarker release – the influence of exercise intensity, duration and mode: a systematic review and meta-analysis
Donaldson, J., Wiles, J., Coleman, D., Papadakis, M., Sharma, R. and O'Driscoll, J. 2019. Left ventricular function and cardiac biomarker release – the influence of exercise intensity, duration and mode: a systematic review and meta-analysis. Sports Medicine. https://doi.org/10.1007/s40279-019-01142-5
Cardiac maladaptation in obese pregnancy at term
Buddeberg, B., Sharma, R., O'Driscoll, J., Kaelin Agten, A., Khalil, A. and Thilaganathan, B. 2018. Cardiac maladaptation in obese pregnancy at term. Ultrasound in Obstetrics and Gynecology. https://doi.org/10.1002/uog.20170
A 4-week resistance training intervention improves stability, strength and neuromuscular activity in the lower limb: a case study of a cerebral palsy adult
McManus, A., Bembridge, M., Scales, J., Wiles, J., Coleman, D. and O'Driscoll, J. 2018. A 4-week resistance training intervention improves stability, strength and neuromuscular activity in the lower limb: a case study of a cerebral palsy adult. International Journal of Sports Science & Medicine. 2 (2), pp. 050-055.
Neurohumoral and ambulatory haemodynamic adaptations following isometric exercise training in unmedicated hypertensive patients
Taylor, K., Wiles, J., Coleman, D., Leeson, P., Sharma, R. and O'Driscoll, J. 2018. Neurohumoral and ambulatory haemodynamic adaptations following isometric exercise training in unmedicated hypertensive patients. Journal of Hypertension. https://doi.org/10.1097/HJH.0000000000001922
Cardiac autonomic and left ventricular mechanics following high intensity interval training: a randomised cross-over controlled study.
O'Driscoll, J., Wrigth, S., Taylor, K., Coleman, D., Sharma, R. and Wiles, J. 2018. Cardiac autonomic and left ventricular mechanics following high intensity interval training: a randomised cross-over controlled study. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00056.2018
Cardiac maladaptation in term pregnancies with preeclampsia
Buddeberg, B., Sharma, R., O'Driscoll, J., Kaelin Agten, A., Khalil, A. and Thilaganathan, B. 2018. Cardiac maladaptation in term pregnancies with preeclampsia. Pregnancy Hypertension. 13, pp. 198-203. https://doi.org/10.1016/j.preghy.2018.06.015
The safety of isometric exercise: rethinking the exercise prescription paradigm for those with stage 1 hypertension.
Wiles, J., Taylor, K., Coleman, D., Sharma, R. and O'Driscoll, J. 2018. The safety of isometric exercise: rethinking the exercise prescription paradigm for those with stage 1 hypertension. Medicine. 97 (10). https://doi.org/10.1097/MD.0000000000010105
An alternative approach to isometric exercise training prescription for cardiovascular health
Wiles, J., Goldring, N., O'Driscoll, J., Taylor, K. and Coleman, D. 2018. An alternative approach to isometric exercise training prescription for cardiovascular health. Translational Journal of the American College of Sports Medicine. 3 (2), pp. 10-18. https://doi.org/10.1249/TJX.0000000000000052
Baseline mitral regurgitation predicts outcome in patients referred for dobutamine stress echocardiography
O'Driscoll, J., Gargallo-Fernandez, P., Araco, M., Perez-Lopez, M. and Sharma, R. 2017. Baseline mitral regurgitation predicts outcome in patients referred for dobutamine stress echocardiography. International Journal of Cardiovascular Imaging. https://doi.org/10.1007/s10554-017-1163-6
Blood pressure responses to isometric exercise: safety considerations for exercise prescription
Wiles, J., Taylor, K., Coleman, D., Sharma, R. and O'Driscoll, J. 2017. Blood pressure responses to isometric exercise: safety considerations for exercise prescription.
Ambulatory blood pressure responses to home-based isometric exercise training in pre-hypertensive males
Taylor, K., Wiles, J., Coleman, D., Sharma, R. and O'Driscoll, J. 2017. Ambulatory blood pressure responses to home-based isometric exercise training in pre-hypertensive males.
Cardiac autonomic modulation and high intensity interval training in physically inactive men
O'Driscoll, J., Wright, S., Taylor, K., Coleman, D. and Wiles, J. 2017. Cardiac autonomic modulation and high intensity interval training in physically inactive men.
A higher effort-based paradigm in physical activity and exercise for public health: making the case for a greater emphasis on resistance training
Steele, J., Fisher, J., Skivington, M., Dunn, C., Arnold, J., Tew, G., Batterham, A., Nunan, D., O'Driscoll, J., Mann, S., Beedie, C., Jobson, S., Smith, D., Vigotsky, A., Phillips, S., Estabrooks, P. and Winett, R. 2017. A higher effort-based paradigm in physical activity and exercise for public health: making the case for a greater emphasis on resistance training. BMC Public Health. https://doi.org/10.1186/s12889-017-4209-8
Continuous cardiac autonomic and haemodynamic responses to isometric exercise in pre-hypertensive males
Taylor, K., Wiles, J., Coleman, D., Sharma, R. and O'Driscoll, J. 2017. Continuous cardiac autonomic and haemodynamic responses to isometric exercise in pre-hypertensive males. Medicine & Science in Sports & Exercise (MSSE). https://doi.org/10.1249/MSS.0000000000001271
Acute cardiac functional and mechanical responses to isometric exercise in pre-hypertensive males
O'Driscoll, J., Taylor, K., Wiles, J., Coleman, D. and Sharma, R. 2017. Acute cardiac functional and mechanical responses to isometric exercise in pre-hypertensive males. Physiological Reports. https://doi.org/10.14814/phy2.13236
Body mass index mortality paradox in chronic kidney disease patients with suspected cardiac chest pain
O'Driscoll, J., Slee, A. and Sharma, R. 2017. Body mass index mortality paradox in chronic kidney disease patients with suspected cardiac chest pain. Journal of Cachexia, Sarcopenia and Muscle Clinical Reports. 2 (1).
Strongman training – Needs analysis and integration into strength and conditioning programming: part 2.
McManus, A., O'Driscoll, J., Coleman, D. and Wiles, J. 2016. Strongman training – Needs analysis and integration into strength and conditioning programming: part 2. Professional Strength & Conditioning. 44, pp. 7-15.
Strongman training – a rationale for its inclusion in strength & conditioning: part 1
McManus, A., Wiles, J., Coleman, D. and O'Driscoll, J. 2016. Strongman training – a rationale for its inclusion in strength & conditioning: part 1. Professional Strength & Conditioning. 43, pp. 7-18.
Acute cardiac autonomic responses to an incremental isometric exercise test in pre-hypertensive males
Taylor, K., Wiles, J., Coleman, D., Sharma, R. and O'Driscoll, J. 2016. Acute cardiac autonomic responses to an incremental isometric exercise test in pre-hypertensive males.
Transthoracic echocardiography provides important long-term prognostic information in selected patients undergoing endovascular abdominal aortic repair
O'Driscoll, J., Bahia, S., Gravina, A., Di Fino, S., Thompson, M., Karthikesalingam, A., Holt, P. and Sharma, R. 2016. Transthoracic echocardiography provides important long-term prognostic information in selected patients undergoing endovascular abdominal aortic repair. Circulation Cardiovascular Imaging. https://doi.org/10.1161/CIRCIMAGING.115.003557
Reverse left ventricular remodelling - effect of cardiac rehabilitation exercise training in myocardial infarction patients with preserved ejection fraction
McGregor, G., Gaze, D., Oxborough, D., O'Driscoll, J. and Shave, R. 2015. Reverse left ventricular remodelling - effect of cardiac rehabilitation exercise training in myocardial infarction patients with preserved ejection fraction. European Journal of Physcial and Rehabilitation Medicine. 52 (3), pp. 370-378.
The prognostic value of dobutamine stress echocardiography amongst British Indian Asian and Afro-Caribbean patients: a comparison with European white patients
O'Driscoll, J., Rossato, C., Gargallo-Fernandez, P., Araco, M., Giannoglou, D., Sharma, S. and Sharma, R. 2015. The prognostic value of dobutamine stress echocardiography amongst British Indian Asian and Afro-Caribbean patients: a comparison with European white patients. Cardiovascular Ultrasound. 13 (36). https://doi.org/10.1186/s12947-015-0028-1
Non-invasive assessment of the autonomic nervous system
O'Driscoll, J. and Sharma, R. 2015. Non-invasive assessment of the autonomic nervous system. International Journal of Clinical Therapeutics and Diagnosis. 3 (3), pp. 85-91.
Differing autonomic responses to dobutamine stress in the presence and absence of myocardial ischaemia
Sharma, R., O'Driscoll, J., Saha, A., Sritharan, M., Sutton, R. and Rosen, S. 2015. Differing autonomic responses to dobutamine stress in the presence and absence of myocardial ischaemia. The Journal of Physiology. 593 (9), pp. 2171-2184. https://doi.org/10.1113/JP270063
The safety and clinical usefulness of dobutamine stress echocardiography among octogenarians
O'Driscoll, J., Marciniak, A., Ray, K., Schmid, K., Smith, R. and Sharma, R. 2014. The safety and clinical usefulness of dobutamine stress echocardiography among octogenarians. Heart. 2014 (100), pp. 1001-1007. https://doi.org/10.1136/heartjnl-2013-305229
The implementation of problem based learning styles to teach the Coach-Athlete relationship to undergraduate Sport and Exercise Science students
Rossato, C. and O'Driscoll, J. 2013. The implementation of problem based learning styles to teach the Coach-Athlete relationship to undergraduate Sport and Exercise Science students. International Journal of Sport Studies. 3, pp. 859-864.
Differing autonomic responses to dobutamine stress in the presence and absence of myocardial ischaemia
Sharma, R., O'Driscoll, J., Bromley, P., Sritharan, M. and Rosen, S. 2008. Differing autonomic responses to dobutamine stress in the presence and absence of myocardial ischaemia.
Dobutamine stress echocardiography accurately detects significant coronary artery disease in Indian Asians living in the United Kingdom
Itam, S., O'Driscoll, J., Milad, E. and Sharma, R. 2008. Dobutamine stress echocardiography accurately detects significant coronary artery disease in Indian Asians living in the United Kingdom.
The effects of a high-protein, paleolithic-type diet on body composition and exercise performance in amateur mixed martial artists
Slee, A., O'Driscoll, J., Burnet, S., Hughes, G. and Chen, M. 2009. The effects of a high-protein, paleolithic-type diet on body composition and exercise performance in amateur mixed martial artists.
Subjective global assessment is an independent predictor of cardiac ischaemia in patients with mild chronic kidney disease
Aldous, G., Sharma, R., O'Driscoll, J., Ashby, D., Tarn, F. and Choi, P. 2010. Subjective global assessment is an independent predictor of cardiac ischaemia in patients with mild chronic kidney disease.
A National Health Service hospital's cardiac rehabilitation programme: a qualitative analysis of provision
O'Driscoll, J., Shave, R. and Cushion, C. 2007. A National Health Service hospital's cardiac rehabilitation programme: a qualitative analysis of provision. Journal of Clinical Nursing. 16 (10), pp. 1908-1918. https://doi.org/10.1111/j.1365-2702.2007.01815.x
Inequalities in the training and implementation of cardiac rehabilitation in the United Kingdom
O'Driscoll, J. and Sharma, R. 2009. Inequalities in the training and implementation of cardiac rehabilitation in the United Kingdom. in: Bennington, E. (ed.) Horizons in World Cardiovascular Research Hauppauge, New York Nova Science Publishers.