Speckle tracking echocardiography: new ways of translational approaches in preeclampsia to detect cardiovascular dysfunction

Journal article


Kraker, K., Schutte, T., O'Driscoll, J., Birukov, A., Patey, O., Herse, F., Muller, D.N., Thilaganathan, B., Haase, N. and Dechend, R. 2020. Speckle tracking echocardiography: new ways of translational approaches in preeclampsia to detect cardiovascular dysfunction. International Journal of Molecular Sciences. 21 (3). https://doi.org/10.3390/ijms21031162
AuthorsKraker, K., Schutte, T., O'Driscoll, J., Birukov, A., Patey, O., Herse, F., Muller, D.N., Thilaganathan, B., Haase, N. and Dechend, R.
Abstract

Several studies have shown that women with a preeclamptic pregnancy exhibit an increased risk of cardiovascular disease. However, the underlying molecular mechanisms are unknown. Animal models are essential to investigate the causes of this increased risk and have the ability to assess possible preventive and therapeutic interventions. Using the latest technologies such as speckle tracking echocardiography (STE), it is feasible to map subclinical changes in cardiac diastolic and systolic function as well as structural changes of the maternal heart. The aim of this work is to compare cardiovascular changes in an established transgenic rat model with preeclampsia-like pregnancies with findings from human preeclamptic pregnancies by STE. The same algorithms were used to evaluate and compare the changes in echos of human and rodents. Parameters of functionality like global longitudinal strain (animal -23.54 ± 1.82 % vs. -13.79 ± 0.57 %, human -20.60 ± 0.47 % vs. -15.45 ± 1.55 %) as well as indications of morphological changes like relative wall thickness (animal 0.20 ± 0.01 vs. 0.25 ± 0.01, human 0.34 ± 0.01 vs. 0.40 ± 0.02) are significantly altered in both species after preeclamptic pregnancies. Thus, the described rat model simulates the human situation quite well and is a valuable tool for future investigations regarding cardiovascular changes. STE is a unique technique which can be applied in animal models and human with a high potential to uncover cardiovascular maladaptation and subtle pathologies.

KeywordsPreeclampsia; pregnancy; speckle tracking echocardiography; cardiovascular dysfunction; animal models of human disease
Year2020
JournalInternational Journal of Molecular Sciences
Journal citation21 (3)
PublisherMDPI
ISSN1661-6596
Digital Object Identifier (DOI)https://doi.org/10.3390/ijms21031162
Official URLhttps://doi.org/10.3390/ijms21031162
Related URLhttps://www.mdpi.com/
Publication dates
Online10 Feb 2020
Publication process dates
Accepted03 Feb 2020
Deposited18 Feb 2020
Accepted author manuscript
License
File Access Level
Open
Output statusPublished
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https://repository.canterbury.ac.uk/item/8qv60/speckle-tracking-echocardiography-new-ways-of-translational-approaches-in-preeclampsia-to-detect-cardiovascular-dysfunction

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