Multicenter cohort study, with a nested randomized comparison, to examine the cardiovascular impact of preterm preeclampsia
Journal article
McCarthy, F.P., O'Driscoll, J., Seed, P.T., Placzek, A., Gill, C., Sparkes, J., Poston, L., Marber, M., Shennan, A.H., Thilaganathan, B., Leeson, P. and Chappell, L.C. 2021. Multicenter cohort study, with a nested randomized comparison, to examine the cardiovascular impact of preterm preeclampsia. Hypertension. https://doi.org/10.1161/HYPERTENSIONAHA.121.17171
Authors | McCarthy, F.P., O'Driscoll, J., Seed, P.T., Placzek, A., Gill, C., Sparkes, J., Poston, L., Marber, M., Shennan, A.H., Thilaganathan, B., Leeson, P. and Chappell, L.C. |
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Abstract | This study evaluated whether planned early delivery would ameliorate cardiovascular dysfunction six months postpartum, compared to usual care with expectant management, in women with late preterm preeclampsia. We conducted a mechanistic observational study in women with preterm preeclampsia between 34+0 and 36+6 weeks’ gestation, nested within a randomised controlled trial of planned early delivery versus expectant management (usual care), in 28 maternity hospitals in England and Wales. Women were followed up six months postpartum with cardiovascular assessments. The primary outcome was a composite of systolic and/or diastolic dysfunction (by 2009 and 2016 definitions of diastolic dysfunction). |
Keywords | Preterm preeclampsia; Hypertension; Cardiovascular dysfunction; Pregnancy |
Year | 2021 |
Journal | Hypertension |
Publisher | American Heart Association |
Lippincott, Williams and Wilkins | |
ISSN | 0194-911X |
1524-4563 | |
Digital Object Identifier (DOI) | https://doi.org/10.1161/HYPERTENSIONAHA.121.17171 |
Official URL | https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17171 |
Publication dates | |
Online | 30 Aug 2021 |
Publication process dates | |
Accepted | 14 Jul 2021 |
Deposited | 13 Sep 2021 |
Publisher's version | License File Access Level Open |
Output status | Published |
https://repository.canterbury.ac.uk/item/8y98y/multicenter-cohort-study-with-a-nested-randomized-comparison-to-examine-the-cardiovascular-impact-of-preterm-preeclampsia
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