Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients.
O'Driscoll, J., Edwards, J., Wiles, J., Taylor, K., Leeson, P. and Sharma, R. 2022. Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients. European Journal of Applied Physiology.
|Authors||O'Driscoll, J., Edwards, J., Wiles, J., Taylor, K., Leeson, P. and Sharma, R.|
Purpose: Hypertension is a major risk factor for cardiovascular disease. Isometric exercise training (IET) reduces resting and ambulatory blood pressure; however, few studies have investigated the myocardial adaptations following IET.
Methods: We randomly assigned 24 unmedicated hypertensive patients in a cross-over study design to 4-weeks of IET and control period, separated by a 3-week washout period. Speckle tracking echocardiography was used to measure left ventricular (LV) mechanics, and global myocardial work indices were derived from non-invasive LV pressure-strain loops constructed from global longitudinal strain (GLS) indexed to brachial systolic blood pressure.
Results: IET significantly improved GLS (-2.3±2%, p<0.001) and global work efficiency (2.8±2%, p<0.001), and significantly reduced global wasted work (-42.5±30 mmHg%, p<0.001) with no significant change during the control period.
Conclusions: This is the first evidence to demonstrate that IET significantly improved cardiac health in a relevant patient population. Our findings have important clinical implications for patients with high blood pressure and support the role of IET as a safe and viable therapeutic and preventative intervention in the treatment of hypertension.
|Keywords||Cardiac mechanics; Hypertension; Myocardial work; Isometric exercise training|
|Journal||European Journal of Applied Physiology|
|Publication process dates|
|Accepted||22 Dec 2021|
|Deposited||05 Jan 2022|
|Accepted author manuscript|
File Access Level
|Output status||In press|
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