Feasibility study to assess the delivery of a novel isometric exercise intervention for people with stage 1 hypertension in the NHS: protocol for the IsoFIT-BP study including amendments to mitigate the risk of COVID-19.

Journal article


Wiles, J., Rees-Roberts, Melanie, O'Driscoll, J., Doulton, Timothy, MacInnes, D., Short, Vanessa, Pellatt-Higgins, Tracy, Saxby, Katie, Gousia, K., West, Alan, Smith, Maggie, Santer, E., Darby, John and Farmer, Chris K 2021. Feasibility study to assess the delivery of a novel isometric exercise intervention for people with stage 1 hypertension in the NHS: protocol for the IsoFIT-BP study including amendments to mitigate the risk of COVID-19. Pilot and Feasibility Studies. 7 (1), p. 192. https://doi.org/10.1186/s40814-021-00925-w
AuthorsWiles, J., Rees-Roberts, Melanie, O'Driscoll, J., Doulton, Timothy, MacInnes, D., Short, Vanessa, Pellatt-Higgins, Tracy, Saxby, Katie, Gousia, K., West, Alan, Smith, Maggie, Santer, E., Darby, John and Farmer, Chris K
Abstract<h4>Background</h4>Hypertension  (HTN) affects approximately 25% of the UK population and is a leading cause of mortality. Associated annual health care costs run into billions. National treatment guidance includes initial lifestyle advice, followed by anti-hypertensive medication if blood pressure (BP) remains high. However, adoption and adherence to recommended exercise guidelines, dietary advice and anti-hypertensive medication is poor. Four short bouts of isometric exercise (IE) performed 3 days per week (d/wk) at home elicits clinically significant reductions in BP in those with normal to high-normal BP. This study will determine the feasibility of delivering personalised IE to patients with stage 1 hypertension for whom lifestyle changes would be recommended before medication within NHS primary care.<h4>Methods</h4>This is a randomised controlled feasibility study. Participants were 18+ years, with stage 1 hypertension, not on anti-hypertensive medication and without significant medical contraindications. Trial arms will be standard lifestyle advice (control) or isometric wall squat exercise and standard lifestyle advice. Primary outcomes include the feasibility of healthcare professionals to deliver isometric exercise prescriptions in a primary care NHS setting and estimation of the variance of change in systolic BP. Secondary outcomes include accuracy of protocol delivery, execution of and adherence to protocol, recruitment rate, attrition, perception of intervention viability, cost, participant experience and accuracy of home BP. The study will last 18 months. Sample size of 100 participants (50 per arm) allows for 20% attrition and 6.5% incomplete data, based upon 74 (37 each arm) participants (two-sided 95% confidence interval, width of 1.33 and standard deviation of 4) completing 4 weeks. Ethical approval IRAS ID is 274676.<h4>Discussion</h4>Before the efficacy of this novel intervention to treat stage 1 hypertension can be investigated in any large randomised controlled trial, it is necessary to ascertain if it can be delivered and carried out in a NHS primary care setting. Findings could support IE viability as a prophylactic/alternative treatment option.<h4>Trial registration</h4>ISRCTN13472393 , registered 18 August 2020.
KeywordsHypertension; Exercise; General Practice; Feasibility Study; Isometric Exercise; Covid-19
Year2021
JournalPilot and Feasibility Studies
Journal citation7 (1), p. 192
PublisherBMC
ISSN2055-5784
Digital Object Identifier (DOI)https://doi.org/10.1186/s40814-021-00925-w
Official URLhttps://pilotfeasibilitystudies.biomedcentral.com/articles/10.1186/s40814-021-00925-w
FunderResearch for Patient Benefit Programme
National Institute for Health and Care Research (NIHR)
Publication dates
Online28 Oct 2021
Print01 Oct 2021
Publication process dates
Accepted29 Sep 2021
Deposited01 Nov 2021
Publisher's version
File Access Level
Open
Output statusPublished
LicenseCC BY
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Buddeberg, B., Sharma, R., O'Driscoll, J., Kaelin Agten, A., Khalil, A. and Thilaganathan, B. 2018. Cardiac maladaptation in term pregnancies with preeclampsia. Pregnancy Hypertension. 13, pp. 198-203. https://doi.org/10.1016/j.preghy.2018.06.015
Partial swing golf shots: scaled from full swing or independent technique?
Todd, S., Wiles, J., Coleman, D. and Brown, M. 2018. Partial swing golf shots: scaled from full swing or independent technique? Sports Biomechanics. https://doi.org/10.1080/14763141.2018.1480727
The safety of isometric exercise: rethinking the exercise prescription paradigm for those with stage 1 hypertension.
Wiles, J., Taylor, K., Coleman, D., Sharma, R. and O'Driscoll, J. 2018. The safety of isometric exercise: rethinking the exercise prescription paradigm for those with stage 1 hypertension. Medicine. 97 (10). https://doi.org/10.1097/MD.0000000000010105
An alternative approach to isometric exercise training prescription for cardiovascular health
Wiles, J., Goldring, N., O'Driscoll, J., Taylor, K. and Coleman, D. 2018. An alternative approach to isometric exercise training prescription for cardiovascular health. Translational Journal of the American College of Sports Medicine. 3 (2), pp. 10-18. https://doi.org/10.1249/TJX.0000000000000052
Psychosocial interventions to support carers
MacInnes, D., Francis, A. and Jeffrey, A. 2018. Psychosocial interventions to support carers. in: Wright, K. and McKeown, M. (ed.) Essentials of Mental Health Nursing London SAGE Publications.
The effects of acute carbohydrate and caffeine feeding strategies on cycling efficiency
Cole, M., Hopker, J., Wiles, J. and Coleman, D. 2017. The effects of acute carbohydrate and caffeine feeding strategies on cycling efficiency. Journal of Sports Sciences. https://doi.org/10.1080/02640414.2017.1343956
Baseline mitral regurgitation predicts outcome in patients referred for dobutamine stress echocardiography
O'Driscoll, J., Gargallo-Fernandez, P., Araco, M., Perez-Lopez, M. and Sharma, R. 2017. Baseline mitral regurgitation predicts outcome in patients referred for dobutamine stress echocardiography. International Journal of Cardiovascular Imaging. https://doi.org/10.1007/s10554-017-1163-6
Blood pressure responses to isometric exercise: safety considerations for exercise prescription
Wiles, J., Taylor, K., Coleman, D., Sharma, R. and O'Driscoll, J. 2017. Blood pressure responses to isometric exercise: safety considerations for exercise prescription.
Ambulatory blood pressure responses to home-based isometric exercise training in pre-hypertensive males
Taylor, K., Wiles, J., Coleman, D., Sharma, R. and O'Driscoll, J. 2017. Ambulatory blood pressure responses to home-based isometric exercise training in pre-hypertensive males.
Cardiac autonomic modulation and high intensity interval training in physically inactive men
O'Driscoll, J., Wright, S., Taylor, K., Coleman, D. and Wiles, J. 2017. Cardiac autonomic modulation and high intensity interval training in physically inactive men.
A higher effort-based paradigm in physical activity and exercise for public health: making the case for a greater emphasis on resistance training
Steele, J., Fisher, J., Skivington, M., Dunn, C., Arnold, J., Tew, G., Batterham, A., Nunan, D., O'Driscoll, J., Mann, S., Beedie, C., Jobson, S., Smith, D., Vigotsky, A., Phillips, S., Estabrooks, P. and Winett, R. 2017. A higher effort-based paradigm in physical activity and exercise for public health: making the case for a greater emphasis on resistance training. BMC Public Health. https://doi.org/10.1186/s12889-017-4209-8
Continuous cardiac autonomic and haemodynamic responses to isometric exercise in pre-hypertensive males
Taylor, K., Wiles, J., Coleman, D., Sharma, R. and O'Driscoll, J. 2017. Continuous cardiac autonomic and haemodynamic responses to isometric exercise in pre-hypertensive males. Medicine & Science in Sports & Exercise (MSSE). https://doi.org/10.1249/MSS.0000000000001271
Acute cardiac functional and mechanical responses to isometric exercise in pre-hypertensive males
O'Driscoll, J., Taylor, K., Wiles, J., Coleman, D. and Sharma, R. 2017. Acute cardiac functional and mechanical responses to isometric exercise in pre-hypertensive males. Physiological Reports. https://doi.org/10.14814/phy2.13236
Body mass index mortality paradox in chronic kidney disease patients with suspected cardiac chest pain
O'Driscoll, J., Slee, A. and Sharma, R. 2017. Body mass index mortality paradox in chronic kidney disease patients with suspected cardiac chest pain. Journal of Cachexia, Sarcopenia and Muscle Clinical Reports. 2 (1).
Strongman training – Needs analysis and integration into strength and conditioning programming: part 2.
McManus, A., O'Driscoll, J., Coleman, D. and Wiles, J. 2016. Strongman training – Needs analysis and integration into strength and conditioning programming: part 2. Professional Strength & Conditioning. 44, pp. 7-15.
Strongman training – a rationale for its inclusion in strength & conditioning: part 1
McManus, A., Wiles, J., Coleman, D. and O'Driscoll, J. 2016. Strongman training – a rationale for its inclusion in strength & conditioning: part 1. Professional Strength & Conditioning. 43, pp. 7-18.
Knowlege transfer partnerships
MacInnes, D., Jones, F., Stirrup, V., Dimond, I and Green, D 2017. Knowlege transfer partnerships. Swindon, UK Innovate UK.
Home-based isometric exercise training induced reductions resting blood pressure
Wiles, J., Goldring, N. and Coleman, D. 2016. Home-based isometric exercise training induced reductions resting blood pressure. European Journal of Applied Physiology. https://doi.org/10.1007/s00421-016-3501-0
Acute cardiac autonomic responses to an incremental isometric exercise test in pre-hypertensive males
Taylor, K., Wiles, J., Coleman, D., Sharma, R. and O'Driscoll, J. 2016. Acute cardiac autonomic responses to an incremental isometric exercise test in pre-hypertensive males.
Immediate post-isometric exercise cardiovascular responses are associated with training-induced resting systolicblood pressure reductions
Wiles, J., Devereux, G. and Howden, R. 2015. Immediate post-isometric exercise cardiovascular responses are associated with training-induced resting systolicblood pressure reductions. European Journal of Applied Physiology. 115 (2), pp. 327-333. https://doi.org/10.1007/s00421-014-3021-8
The Comquol Study: a structured approach focused on quality of life in secure mental health settings
MacInnes, D. 2015. The Comquol Study: a structured approach focused on quality of life in secure mental health settings.
The comquol study
MacInnes, D., Mansfield, J., Kinane, C. and Parrott, J. 2012. The comquol study.
Carers and carers' rights of mentally disordered offenders
MacInnes, D. 2014. Carers and carers' rights of mentally disordered offenders. in: Taylor, P., Corteen, K. and Morley, S. (ed.) A Companion to Criminal Justice, Mental Health and Risk Bristol Policy Press. pp. 42-43
In the case of prostate cancer patients, are there advantages in cancer nurse-led follow-up?
MacInnes, D., Vieira, I. and Sheriff, M. 2016. In the case of prostate cancer patients, are there advantages in cancer nurse-led follow-up? International Journal of Urological Nursing. https://doi.org/10.1111/ijun.12112
Carers of forensic mental health in-patients: what factors influence their satisfaction with services?
MacInnes, D., Beer, D., Reynolds, K. and Kinane, C. 2013. Carers of forensic mental health in-patients: what factors influence their satisfaction with services? Journal of Mental Health. 22 (6), pp. 526-535. https://doi.org/10.3109/09638237.2013.841873
A cross sectional survey examining the association between therapeutic relationships and service user satisfaction in forensic mental health settings
MacInnes, D., Courtney, H., Flanagan, T., Bressington, D. and Beer, D. 2014. A cross sectional survey examining the association between therapeutic relationships and service user satisfaction in forensic mental health settings. BMC Research Notes. 7 (657). https://doi.org/10.1186/1756-0500-7-657
Study to assess the effect of a structured communication approach on quality of life in secure mental health settings (Comquol): study protocol for a pilot cluster randomized trial
MacInnes, D., Kinane, C., Beer, D., Parrott, J., Craig, T., Eldridge, S., Krotofil, J. and Priebe, S. 2013. Study to assess the effect of a structured communication approach on quality of life in secure mental health settings (Comquol): study protocol for a pilot cluster randomized trial. Trials. 14 (257). https://doi.org/10.1186/1745-6215-14-257
Transthoracic echocardiography provides important long-term prognostic information in selected patients undergoing endovascular abdominal aortic repair
O'Driscoll, J., Bahia, S., Gravina, A., Di Fino, S., Thompson, M., Karthikesalingam, A., Holt, P. and Sharma, R. 2016. Transthoracic echocardiography provides important long-term prognostic information in selected patients undergoing endovascular abdominal aortic repair. Circulation Cardiovascular Imaging. https://doi.org/10.1161/CIRCIMAGING.115.003557
Reverse left ventricular remodelling - effect of cardiac rehabilitation exercise training in myocardial infarction patients with preserved ejection fraction
McGregor, G., Gaze, D., Oxborough, D., O'Driscoll, J. and Shave, R. 2015. Reverse left ventricular remodelling - effect of cardiac rehabilitation exercise training in myocardial infarction patients with preserved ejection fraction. European Journal of Physcial and Rehabilitation Medicine. 52 (3), pp. 370-378.
A pilot cluster randomised trial to assess the effect of a structured communication approach on quality of life in secure mental health settings: the Comquol study
MacInnes, D., Kinane, C., Parrott, J., Mansfield, J., Craig, T., Eldridge, S., Marsh, I., Chan, C., Hounsome, N., Harrison, G. and Priebe, S. 2016. A pilot cluster randomised trial to assess the effect of a structured communication approach on quality of life in secure mental health settings: the Comquol study. BMC Psychiatry. 16 (335). https://doi.org/10.1186/s12888-016-1046-8
The Comquol Study: - a pilot cluster randomised trial looking at a structured communication intervention in secure mental health settings: outcomes and challenges
MacInnes, D., Kinane, C., Parrott, J. and Mansfield, J. 2016. The Comquol Study: - a pilot cluster randomised trial looking at a structured communication intervention in secure mental health settings: outcomes and challenges.
The Delphi method: methodological issues arising from a study examining factors influencing the publication or non-publication of mental health nursing research
MacInnes, D., Flanagan, T., Ashmore, R. and Banks, D. 2016. The Delphi method: methodological issues arising from a study examining factors influencing the publication or non-publication of mental health nursing research. Mental Health Review Journal. 21 (2), pp. 85-94. https://doi.org/10.1108/MHRJ-07-2015-0020
The prognostic value of dobutamine stress echocardiography amongst British Indian Asian and Afro-Caribbean patients: a comparison with European white patients
O'Driscoll, J., Rossato, C., Gargallo-Fernandez, P., Araco, M., Giannoglou, D., Sharma, S. and Sharma, R. 2015. The prognostic value of dobutamine stress echocardiography amongst British Indian Asian and Afro-Caribbean patients: a comparison with European white patients. Cardiovascular Ultrasound. 13 (36). https://doi.org/10.1186/s12947-015-0028-1
Non-invasive assessment of the autonomic nervous system
O'Driscoll, J. and Sharma, R. 2015. Non-invasive assessment of the autonomic nervous system. International Journal of Clinical Therapeutics and Diagnosis. 3 (3), pp. 85-91.
Differing autonomic responses to dobutamine stress in the presence and absence of myocardial ischaemia
Sharma, R., O'Driscoll, J., Saha, A., Sritharan, M., Sutton, R. and Rosen, S. 2015. Differing autonomic responses to dobutamine stress in the presence and absence of myocardial ischaemia. The Journal of Physiology. 593 (9), pp. 2171-2184. https://doi.org/10.1113/JP270063
The safety and clinical usefulness of dobutamine stress echocardiography among octogenarians
O'Driscoll, J., Marciniak, A., Ray, K., Schmid, K., Smith, R. and Sharma, R. 2014. The safety and clinical usefulness of dobutamine stress echocardiography among octogenarians. Heart. 2014 (100), pp. 1001-1007. https://doi.org/10.1136/heartjnl-2013-305229
The implementation of problem based learning styles to teach the Coach-Athlete relationship to undergraduate Sport and Exercise Science students
Rossato, C. and O'Driscoll, J. 2013. The implementation of problem based learning styles to teach the Coach-Athlete relationship to undergraduate Sport and Exercise Science students. International Journal of Sport Studies. 3, pp. 859-864.
The comquol study: a structured approach focused on quality of life in secure mental health settings
MacInnes, D., Mansfield, J. and Parrott, J. 2015. The comquol study: a structured approach focused on quality of life in secure mental health settings.
A pilot trial assessing the effect of structured communication approach on quality of life in secure mental health settings (ComQuol) - service focused measures
MacInnes, D., Mansfield J., Kinane, C., Marsh, I. and Parrott, J. 2015. A pilot trial assessing the effect of structured communication approach on quality of life in secure mental health settings (ComQuol) - service focused measures.
A pilot trial assessing the effect of structured communication approach on quality of life in secure mental health settings (ComQuol) - user focused outcomes
MacInnes, D., Parrott, J., Mansfield, J., Kinane, C. and Marsh, I. 2015. A pilot trial assessing the effect of structured communication approach on quality of life in secure mental health settings (ComQuol) - user focused outcomes.
Service user perceptions of the ComQuol approach:focus group analysis
MacInnes, D., Mansfield, J., Marsh, I., Kinane, C. and Parrott, J. 2015. Service user perceptions of the ComQuol approach:focus group analysis.
The role of a mental health nurse in the ComQuol project: their perspective and involvements
MacInnes, D., Mansfield, J., Parrott, J., Marsh, I. and Kinane, C. 2015. The role of a mental health nurse in the ComQuol project: their perspective and involvements.
Clinicians and services users working collaboratively: the ComQuol study
MacInnes, D., Mansfield, J., Kinane, C., Parrott, J. and Marsh, I. 2015. Clinicians and services users working collaboratively: the ComQuol study.
A pilot trial to assess the effect of a structured COMmunication approach on QUality Of Life in secure mental health settings (Comquol)
MacInnes, D., Kinane, C., Parrott, J., Priebe, S., Craig, T., Marsh, I. and Eldridge, S. 2015. A pilot trial to assess the effect of a structured COMmunication approach on QUality Of Life in secure mental health settings (Comquol).
Mental illness and parenthood: being a parent in secure psychiatric care
MacInnes, D., Houben, F. and Parrott, J. 2015. Mental illness and parenthood: being a parent in secure psychiatric care. Criminal Behaviour and Mental Health. 25 (4), pp. 258-272. https://doi.org/10.1002/cbm.1948
A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates
Bressington, D., Stock, J., Hulbert, S. and MacInnes, D. 2015. A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates. International Clinical Psychopharmacology. 30 (4), pp. 230-236. https://doi.org/10.1097/YIC.0000000000000077
Resting blood pressure reductions following isometric leg exercise training are associated with improved flow-mediated vasodilatation
Howland, L., Wiles, J. and Coleman, D. 2014. Resting blood pressure reductions following isometric leg exercise training are associated with improved flow-mediated vasodilatation.
Improved gross efficiency during long duration submaximal cycling following a short-term high carbohydrate diet
Cole, M., Coleman, D., Hopker, J. and Wiles, J. 2014. Improved gross efficiency during long duration submaximal cycling following a short-term high carbohydrate diet. International Journal of Sports Medicine. 35 (3), pp. 265-269. https://doi.org/10.1055/s-0033-1348254
The influence of ageing and training status on exercise efficiency and cycling performance
Hopker, J., Coleman, D., Jobson, S., Von der Haar, T., Wiles, J. and Passfield, L. 2013. The influence of ageing and training status on exercise efficiency and cycling performance.
Reductions in resting blood pressure after isometric exercise training are not related to shear stress
Smith, J., Wiles, J., Swaine, I. and Coleman, D. 2013. Reductions in resting blood pressure after isometric exercise training are not related to shear stress.
Effect of acute isometric bilateral leg extension exercise on brachial and common femoral artery flow-mediated dilatation
Howland, L., Wiles, J., Coleman, D. and Swaine, I. 2013. Effect of acute isometric bilateral leg extension exercise on brachial and common femoral artery flow-mediated dilatation.
The effect of exercise-induced hypohydration upon treadmill running performance
Baker, D., Coleman, D. and Wiles, J. 2013. The effect of exercise-induced hypohydration upon treadmill running performance.
Carbohydrate ingestion improves gross cycling efficiency and subsequent time-trial performance
Cole, M., Hopker, J., Wiles, J. and Coleman, D. 2013. Carbohydrate ingestion improves gross cycling efficiency and subsequent time-trial performance.
The effects of isometric wall squat exercise on heart rate and blood pressure in a normotensive population
Goldring, N., Wiles, J. and Coleman, D. 2013. The effects of isometric wall squat exercise on heart rate and blood pressure in a normotensive population. Journal of Sports Sciences. https://doi.org/10.1080/02640414.2013.809471
The influence of training status, age, and muscle fibre type on cycling efficiency and endurance performance
Hopker, J., Coleman, D., Gregson, H., Jobson, S., Von der Haar, T., Wiles, J. and Passfield, L. 2013. The influence of training status, age, and muscle fibre type on cycling efficiency and endurance performance. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00361.2013
Strengthening healthcare communities through knowledge exchange
Jones, F. and MacInnes, D. 2013. Strengthening healthcare communities through knowledge exchange.
The effects of training mental health practitioners in medication management to address nonadherence: a systematic review of clinician-related outcomes
Bressington, D., Coren, E. and MacInnes, D. 2013. The effects of training mental health practitioners in medication management to address nonadherence: a systematic review of clinician-related outcomes. Nursing: Research and Reviews. 3, pp. 87-98. https://doi.org/10.2147/NRR.S44366
Service-user involvement in forensic mental health care research: areas to consider when developing a collaborative study
MacInnes, D., Beer, D., Keeble, P., Rees, D. and Reid, L. 2011. Service-user involvement in forensic mental health care research: areas to consider when developing a collaborative study. Journal of Mental Health. 20 (5), pp. 464-472. https://doi.org/10.3109/09638231003728109
Risk prevention and non-pharmacological management of violence in the acute setting
MacInnes, D., Patel, S., Olumoroti, J. and McAllister, R. 2013. Risk prevention and non-pharmacological management of violence in the acute setting. in: Khwaja, M. and Beer, D. (ed.) Prevention and Management of Violence: Guidance for Mental Healthcare Professionals London RCPsych Publications.
Why now is the time to invest in e-health technologies
De Weger, E., Jones, F., MacInnes, D., Enser, J. and Francis, S. 2012. Why now is the time to invest in e-health technologies. Health Service Journal [Resource Centre].
Implementing video conferencing in mental health practice
De Weger, E., MacInnes, D., Enser, J., Francis, S. and Jones, F. 2012. Implementing video conferencing in mental health practice. Journal of Psychiatric and Mental Health Nursing. https://doi.org/10.1111/j.1365-2850.2012.01947.x
The reliability of responses to repeated laboratory assessment: the evaluation of a preload-performance protocol in runners
Baker, D., Coleman, D. and Wiles, J. 2011. The reliability of responses to repeated laboratory assessment: the evaluation of a preload-performance protocol in runners.
Change in lactate accumulation after isometric exercise training and its relationship with reduced resting blood pressure
Swaine, I., Devereux, G., Wiles, J. and Coleman, D. 2011. Change in lactate accumulation after isometric exercise training and its relationship with reduced resting blood pressure.
Rapid loss of isometric training-induced reductions in resting blood pressure
Wiles, J., Devereux, G., Coleman, D. and Swaine, I. 2011. Rapid loss of isometric training-induced reductions in resting blood pressure.
Change in the immediate post-exercise blood pressure response after isometric exercise training and its relationship with reduced resting blood pressure
Wiles, J., Swaine, I., Howden, R., McCartney, N. and Coleman, D. 2011. Change in the immediate post-exercise blood pressure response after isometric exercise training and its relationship with reduced resting blood pressure.
Change in shear rate in the common femoral upon cessation of leg isometric exercise at increasing intensities
Swaine, I., Smith, J. and Wiles, J. 2012. Change in shear rate in the common femoral upon cessation of leg isometric exercise at increasing intensities.
Cardio-pulmonary responses to whole-body simulated swimming using a novel swimming training machine
Swaine, I., Wiles, J., Coleman, D., Hunter, A. and Carlton, K. 2010. Cardio-pulmonary responses to whole-body simulated swimming using a novel swimming training machine.
Effects of the intensity of leg isometric training on the vasculature of trained and untrained limbs and resting blood pressure in middle-aged men
Baross, A., Wiles, J. and Swaine, I. 2012. Effects of the intensity of leg isometric training on the vasculature of trained and untrained limbs and resting blood pressure in middle-aged men. International Journal of Vascular Medicine. 2012. https://doi.org/10.1155/2012/964697
Lactate accumulation following isometric exercise training and its relationship with reduced resting blood pressure
Devereux, G., Coleman, D., Wiles, J. and Swaine, I. 2012. Lactate accumulation following isometric exercise training and its relationship with reduced resting blood pressure. Journal of Sports Sciences. 30 (11), pp. 1141-1148. https://doi.org/10.1080/02640414.2012.692482
Markers of isometric training intensity and their relationship with training-induced reductions in resting blood pressure
Devereux, G., Wiles, J. and Swaine, I. 2011. Markers of isometric training intensity and their relationship with training-induced reductions in resting blood pressure. Journal of Sports Sciences. 29 (7), pp. 715-724. https://doi.org/10.1080/02640414.2011.552113
The development of a questionnaire to measure in-patient satisfaction with forensic services - the Forensic Satisfaction Scale
MacInnes, D., Beer, D., Keeble, P., Rees, D. and Reid, L. 2006. The development of a questionnaire to measure in-patient satisfaction with forensic services - the Forensic Satisfaction Scale. Liverpool
Risk assessment in mental illness
MacInnes, D. 2000. Risk assessment in mental illness. London EMAP Healthcare.
The relationship between indices of fatigue and femoral artery post exercise hyperaemia after double-leg isometric exercise at increasing intensities
Smith, J., Wiles, J., Swaine, I. and Coleman, D. 2012. The relationship between indices of fatigue and femoral artery post exercise hyperaemia after double-leg isometric exercise at increasing intensities.
The effects of four weeks home-based isometric exercise training on resting blood pressure
Goldring, N., Wiles, J. and Coleman, D. 2012. The effects of four weeks home-based isometric exercise training on resting blood pressure.
The effects of isometric wall squat exercise on heart rate and blood pressure in a normotensive population
Goldring, N., Wiles, J. and Coleman, D. 2010. The effects of isometric wall squat exercise on heart rate and blood pressure in a normotensive population.
The influence of nutritional interventions on the measurement of gross efficiency during cycling
Cole, M., Coleman, D. and Wiles, J. 2012. The influence of nutritional interventions on the measurement of gross efficiency during cycling.
The effect of short-term dietary manipulation on gross efficiency during cycling
Cole, M., Coleman, D. and Wiles, J. 2011. The effect of short-term dietary manipulation on gross efficiency during cycling.
A case study exploration of the value of acupuncture as an adjunct treatment for patients diagnosed with schizophrenia: results and future study design
Ronan, P., Robinson, N., Harbinson, D. and MacInnes, D. 2011. A case study exploration of the value of acupuncture as an adjunct treatment for patients diagnosed with schizophrenia: results and future study design. Zhong xi yi jie he xue bao = Journal of Chinese Integrative Medicine. 9 (5), pp. 503-514. https://doi.org/10.3736/jcim20110507
The development of a Carer Support Worker service in forensic inpatient mental health settings
MacInnes, D. and Bressington, D. 2011. The development of a Carer Support Worker service in forensic inpatient mental health settings.
The road less travelled: preparing research supervisors in an interprofessional context
Brown, M., Clark, T. and MacInnes, D. 2008. The road less travelled: preparing research supervisors in an interprofessional context.
The relationship between EMG and either heart rate or blood pressure during a single-leg incremental isometric exercise test
Swaine, I., Baross, T., Kay, T. and Wiles, J. 2009. The relationship between EMG and either heart rate or blood pressure during a single-leg incremental isometric exercise test.
Can 4 weeks of isometric exercise lower resting blood pressure in young, healthy, active men?
Swaine, I., Devereux, G. and Wiles, J. 2009. Can 4 weeks of isometric exercise lower resting blood pressure in young, healthy, active men?
Effect of isometric exercise training on resting blood pressure: A meta-analysis of controlled trials
Swaine, I., Owen, A. and Wiles, J. 2009. Effect of isometric exercise training on resting blood pressure: A meta-analysis of controlled trials.
Review of breaches of security in a low secure mental health unit
MacInnes, D. 2009. Review of breaches of security in a low secure mental health unit. Oxleas NHS Foundation Trust.
Caregivers support within forensic mental health services: A multi-site evaluation
MacInnes, D. 2009. Caregivers support within forensic mental health services: A multi-site evaluation. Kent and Medway Partnership Trust and Oxleas NHS Foundation Trust.
What are the reasons for the publication or non-publication of nursing research?
MacInnes, D., Ashmore, R., Banks, D. and Flanagan, T. 2009. What are the reasons for the publication or non-publication of nursing research?
The illness beliefs of caregivers of the mentally ill
MacInnes, D. 2000. The illness beliefs of caregivers of the mentally ill.
The development of an assessment of caregiver burden
MacInnes, D. 1999. The development of an assessment of caregiver burden.
Ethical issues in clinical research
MacInnes, D. 1999. Ethical issues in clinical research. London NT Books.
Using a Delphi approach to ascertain what factors influence the publication of mental health nursing research
MacInnes, D., Ashmore, R., Banks, D. and Flanagan, T. 2007. Using a Delphi approach to ascertain what factors influence the publication of mental health nursing research.
Levels of service user satisfaction in secure settings – A survey of the association between perceived social climate, perceived therapeutic relationship and satisfaction with forensic services
Bressington, D., Stewart, B., Beer, D. and MacInnes, D. 2011. Levels of service user satisfaction in secure settings – A survey of the association between perceived social climate, perceived therapeutic relationship and satisfaction with forensic services. International Journal of Nursing Studies. 48 (11), pp. 1349-1356. https://doi.org/10.1016/j.ijnurstu.2011.05.011
Effects of physical activity, performed in accordance with the current recommendations, on CVD risk factors in 40-65 year old men
Perkins, G., Owen, A., Kearney, E., Wiles, J. and Swaine, I. 2007. Effects of physical activity, performed in accordance with the current recommendations, on CVD risk factors in 40-65 year old men.
Acupuncture and schizophrenia - effect and acceptability: preliminary results of the first UK study
Ronan, P., Harbinson, D., MacInnes, D., Lewis, W. and Robinson, N. 2010. Acupuncture and schizophrenia - effect and acceptability: preliminary results of the first UK study. European Journal of Oriental Medicine. 6 (5), pp. 19-31.
Differing autonomic responses to dobutamine stress in the presence and absence of myocardial ischaemia
Sharma, R., O'Driscoll, J., Bromley, P., Sritharan, M. and Rosen, S. 2008. Differing autonomic responses to dobutamine stress in the presence and absence of myocardial ischaemia.
Dobutamine stress echocardiography accurately detects significant coronary artery disease in Indian Asians living in the United Kingdom
Itam, S., O'Driscoll, J., Milad, E. and Sharma, R. 2008. Dobutamine stress echocardiography accurately detects significant coronary artery disease in Indian Asians living in the United Kingdom.
The effects of a high-protein, paleolithic-type diet on body composition and exercise performance in amateur mixed martial artists
Slee, A., O'Driscoll, J., Burnet, S., Hughes, G. and Chen, M. 2009. The effects of a high-protein, paleolithic-type diet on body composition and exercise performance in amateur mixed martial artists.
Subjective global assessment is an independent predictor of cardiac ischaemia in patients with mild chronic kidney disease
Aldous, G., Sharma, R., O'Driscoll, J., Ashby, D., Tarn, F. and Choi, P. 2010. Subjective global assessment is an independent predictor of cardiac ischaemia in patients with mild chronic kidney disease.
A National Health Service hospital's cardiac rehabilitation programme: a qualitative analysis of provision
O'Driscoll, J., Shave, R. and Cushion, C. 2007. A National Health Service hospital's cardiac rehabilitation programme: a qualitative analysis of provision. Journal of Clinical Nursing. 16 (10), pp. 1908-1918. https://doi.org/10.1111/j.1365-2702.2007.01815.x
Inequalities in the training and implementation of cardiac rehabilitation in the United Kingdom
O'Driscoll, J. and Sharma, R. 2009. Inequalities in the training and implementation of cardiac rehabilitation in the United Kingdom. in: Bennington, E. (ed.) Horizons in World Cardiovascular Research Hauppauge, New York Nova Science Publishers.
Effect of caffeinated coffee on running speed, respiratory factors, blood lactate and perceived exertion during 1500-m treadmill running
Wiles, J., Bird, S., Hopkins, J. and Riley, M. 1992. Effect of caffeinated coffee on running speed, respiratory factors, blood lactate and perceived exertion during 1500-m treadmill running. British Journal of Sports Medicine. 26 (2), pp. 116-120. https://doi.org/10.1136/bjsm.26.2.116
Effect of pre-exercise protein ingestion upon VO2, R and perceived exertion during treadmill running
Wiles, J., Woodward, R. and Bird, S. 1991. Effect of pre-exercise protein ingestion upon VO2, R and perceived exertion during treadmill running. British Journal of Sports Medicine. 25 (1), pp. 26-30. https://doi.org/10.1136/bjsm.25.1.26
Effectiveness of two glycerol ingestion strategies on 40-km cycling time trial performance
Brickell, L., Balmer, J., Theakston, S., Wiles, J. and Bird, S. 2001. Effectiveness of two glycerol ingestion strategies on 40-km cycling time trial performance. Journal of Sports Sciences. 20 (1), pp. 46-47. https://doi.org/10.1080/026404102317126164
We can work it out
Morrissey, M. and Wiles, J. 2001. We can work it out. Nursing Times. 97 (47), pp. 34-36.
Risk assessment in mental health
MacInnes, D. 1998. Risk assessment in mental health.
Attribution theory
MacInnes, D. 1998. Attribution theory. Mental Health Occupational Therapy Magazine. 3, pp. 35-36.
Effects of isometric exercise training intensity upon reductions in resting systolic blood pressure
Wiles, J., Coleman, D. and Swaine, I. 2008. Effects of isometric exercise training intensity upon reductions in resting systolic blood pressure.
A novel method for the performance of isometric exercise in the home
Wiles, J., Coleman, D., Dunford, M. and Swaine, I. 2004. A novel method for the performance of isometric exercise in the home.
The precision with which isometric exercise training can be performed according to a given heart rate
Swaine, I., Wiles, J. and Coleman, D. 2008. The precision with which isometric exercise training can be performed according to a given heart rate.
Effects of three types of isometric leg exercise at the same relative exercise intensities on blood pressure
Swaine, I., Wiles, J., Dunford, M. and Coleman, D. 2004. Effects of three types of isometric leg exercise at the same relative exercise intensities on blood pressure.
The freely chosen contribution of the leg kick to the total power during simulated front crawl swimming on a onland ergometer
Swaine, I., Dunford, M., Wiles, J., Coleman, D., Hunter, A. and Carlton, K. 2006. The freely chosen contribution of the leg kick to the total power during simulated front crawl swimming on a onland ergometer.
The relationship between selected cardiovascular variables and exercise intensity during continuous and discontinuous incremental exercise tests
Allum, S., Wiles, J., Coleman, D. and Swaine, I. 2006. The relationship between selected cardiovascular variables and exercise intensity during continuous and discontinuous incremental exercise tests.
Familiarisation and reliability of sprint test indices during laboratory and field assessment
Hopker, J., Coleman, D., Wiles, J. and Galbraith, A. 2009. Familiarisation and reliability of sprint test indices during laboratory and field assessment. Journal of Sports Science and Medicine. 8 (4), pp. 528-532.
Occurrence of injury during officer safety training at Kent Police
Andrew, J., Henry, T., Coleman, D. and Wiles, J. 2009. Occurrence of injury during officer safety training at Kent Police. The Police Journal. 82 (3), pp. 265-274. https://doi.org/10.1350/pojo.2009.82.3.455
Understanding systemic reviews
MacInnes, D. 2009. Understanding systemic reviews. British Journal of Cardiac Nursing. 4 (7), pp. 331-334.
The effects of performing isometric training at two exercise intensities in healthy young males
Wiles, J., Coleman, D. and Swaine, I. 2010. The effects of performing isometric training at two exercise intensities in healthy young males. European Journal of Applied Physiology. 108 (3), pp. 419-428. https://doi.org/10.1007/s00421-009-1025-6
The effect of training volume and intensity on competitive cyclists’ efficiency
Hopker, J., Coleman, D., Passfield, L. and Wiles, J. 2010. The effect of training volume and intensity on competitive cyclists’ efficiency. Applied Physiology, Nutrition and Metabolism. 35 (1), pp. 17-22. https://doi.org/10.1139/H09-124
Reductions in resting blood pressure after 4 weeks of isometric exercise training
Devereux, G., Wiles, J. and Swaine, I. 2010. Reductions in resting blood pressure after 4 weeks of isometric exercise training. European Journal of Applied Physiology. 109 (4), pp. 601-606. https://doi.org/10.1007/s00421-010-1394-x
Report of the committee of inquiry into current care and treatment practices in the central mental hospital
Parrott, J., Casey, T., Finnerty, S., MacInnes, D. and McMorrow, D. 2007. Report of the committee of inquiry into current care and treatment practices in the central mental hospital. Mental Health Commission.
Effect of isometric exercise on resting blood pressure: a meta analysis
Owen, A., Wiles, J. and Swaine, I. 2010. Effect of isometric exercise on resting blood pressure: a meta analysis. Journal of Human Hypertension. 24 (12), pp. 796-800. https://doi.org/10.1038/jhh.2010.13
Reproducibility of limb power outputs and cardiopulmonary responses to exercise using a novel swimming training machine
Swaine, I., Hunter, A., Carlton, K., Wiles, J. and Coleman, D. 2010. Reproducibility of limb power outputs and cardiopulmonary responses to exercise using a novel swimming training machine. International Journal of Sports Medicine. 31 (12), pp. 854-859. https://doi.org/10.1055/s-0030-1265175
Relatives and informal caregivers
MacInnes, D. 2000. Relatives and informal caregivers. in: Chaloner, C. and Coffey, M. (ed.) Forensic Mental Health Nursing: Current Approaches Oxford Blackwell Science. pp. 208-231
The nurse as researcher
MacInnes, D. 2001. The nurse as researcher. in: Forster, S. (ed.) The Role of the Mental Health Nurse Cheltenham Nelson Thornes. pp. 160-181
The nurse as therapist and counsellor
MacInnes, D., MacDonald, N. and Morrissey, M. 2001. The nurse as therapist and counsellor. in: Forster, S. (ed.) The Role of the Mental Health Nurse Cheltenham Nelson Thornes. pp. 64-91
Advancing practice in family nursing across the cancer continuum
Flanagan, J., Holmes, S. and MacInnes, D. 2002. Advancing practice in family nursing across the cancer continuum. in: Clarke, D., Flanagan, J. and Kendrick, K. (ed.) Advancing Nursing Practice in Cancer and Palliative Care Basingstoke Palgrave Macmillan. pp. 117-139
Relatives and carers of clients with schizophrenia
MacInnes, D. 1996. Relatives and carers of clients with schizophrenia. Mental Health Occupational Therapy Magazine. 1 (1), pp. 16-21.
Illness representations: a way forward in developing therapeutic interventions
MacInnes, D. 1998. Illness representations: a way forward in developing therapeutic interventions. Mental Health Occupational Therapy Magazine. 3 (1), pp. 13-18.
The differences between health professionals in assessing levels of caregiver burden
MacInnes, D. 1998. The differences between health professionals in assessing levels of caregiver burden. Journal of Psychiatric and Mental Health Nursing. 5 (4), pp. 265-271. https://doi.org/10.1046/j.1365-2850.1998.00135.x
The relationship between building design and escapes from secure units
Enser, J. and MacInnes, D. 1999. The relationship between building design and escapes from secure units. The Journal of the Royal Society for the Promotion of Health. 119 (3), pp. 170-174. https://doi.org/10.1177/146642409911900307
Interventions in forensic psychiatry: the caregivers perspective
MacInnes, D. 2000. Interventions in forensic psychiatry: the caregivers perspective. British Journal of Nursing. 9 (15), pp. 992-998.
Nursing in prisons - past, present and future
MacInnes, D. 2000. Nursing in prisons - past, present and future. Health Matters in Prisons. 5 (1), pp. 14-20.
The differences in perceived burdens between forensic and non-forensic caregivers of individuals suffering from schizophrenia
MacInnes, D. and Watson, J. 2002. The differences in perceived burdens between forensic and non-forensic caregivers of individuals suffering from schizophrenia. Journal of Mental Health. 11 (4), pp. 375-388. https://doi.org/10.1080/09638230020023741
Evaluating an assessment scale of irrational beliefs for people with mental health problems
MacInnes, D. 2003. Evaluating an assessment scale of irrational beliefs for people with mental health problems. Nurse Researcher. 10 (4), pp. 53-67.
Contributors to stress among prison service staff
Holmes, S. and MacInnes, D. 2003. Contributors to stress among prison service staff. British Journal of Forensic Practice. 5 (2), pp. 16-24.
The theories underpinning rational emotive behaviour therapy: where's the supportive evidence?
MacInnes, D. 2004. The theories underpinning rational emotive behaviour therapy: where's the supportive evidence? International Journal of Nursing Studies. 41 (6), pp. 685-695. https://doi.org/10.1016/j.ijnurstu.2004.02.004
The development of a tool to measure service user satisfaction with in-patient forensic services: The Forensic Satisfaction Scale
MacInnes, D., Beer, D., Keeble, P., Rees, D. and Reid, L. 2010. The development of a tool to measure service user satisfaction with in-patient forensic services: The Forensic Satisfaction Scale. Journal of Mental Health. 19 (3), pp. 272-281. https://doi.org/10.3109/09638231003728133
The effect of sodium bicarbonate ingestion on 1500-m racing time
Bird, S., Wiles, J. and Robbins, J. 1995. The effect of sodium bicarbonate ingestion on 1500-m racing time. Journal of Sports Sciences. 13 (5), pp. 399-403. https://doi.org/10.1080/02640419508732255
Self-esteem and self-acceptance: an examination into their relationship and their effect on psychological health
MacInnes, D. 2006. Self-esteem and self-acceptance: an examination into their relationship and their effect on psychological health. Journal of Psychiatric and Mental Health Nursing. 13 (5), pp. 483-489.
The evaluation of a short group programme to reduce self-stigma in people with serious and enduring mental health problems
MacInnes, D. and Lewis, M. 2008. The evaluation of a short group programme to reduce self-stigma in people with serious and enduring mental health problems. Journal of Psychiatric and Mental Health Nursing. 15 (1), pp. 59-65. https://doi.org/10.1111/j.1365-2850.2007.01212.x
Validity and reliability of the Ergomopro Powermeter
Kirkland, A., Coleman, D., Wiles, J. and Hopker, J. 2008. Validity and reliability of the Ergomopro Powermeter. International Journal of Sports Medicine. 29 (11), pp. 913-916. https://doi.org/10.1055/s-2008-1038621
The relationships between exercise intensity, heart rate, and blood pressure during an incremental isometric exercise test
Wiles, J., Allum, S., Coleman, D. and Swaine, I. 2007. The relationships between exercise intensity, heart rate, and blood pressure during an incremental isometric exercise test. Journal of Sports Sciences. 26 (2), pp. 155-162. https://doi.org/10.1080/02640410701370655
A novel method for the performance of isometric exercise in the home
Wiles, J., Coleman, D., Dunford, M. and Swaine, I. 2005. A novel method for the performance of isometric exercise in the home. Journal of Sports Sciences. 23 (8), pp. 795-803. https://doi.org/10.1080/02640410400021658
The effects of caffeine ingestion on performance time, speed and power during a laboratory-based 1 km cycling time-trial
Wiles, J., Coleman, D., Tegerdine, M. and Swaine, I. 2006. The effects of caffeine ingestion on performance time, speed and power during a laboratory-based 1 km cycling time-trial. Journal of Sports Sciences. 24 (11), pp. 1165-1171. https://doi.org/10.1080/02640410500457687
Validity and reliability of a new isometric hand dynamometer
Wiles, J., Boyson, H., Balmer, J. and Bird, S. 2001. Validity and reliability of a new isometric hand dynamometer. Sports Engineering. 4 (3), pp. 147-152. https://doi.org/10.1046/j.1460-2687.2001.00080.x
Relationships between pulse wave velocity and heart rate variability in healthy men with a range of moderate-to-vigorous physical activity levels
Perkins, G., Owen, A., Swaine, I. and Wiles, J. 2006. Relationships between pulse wave velocity and heart rate variability in healthy men with a range of moderate-to-vigorous physical activity levels. European Journal of Applied Physiology. 98 (5), pp. 516-523. https://doi.org/10.1007/s00421-006-0303-9
Differences in efficiency between trained and recreational cyclists
Hopker, J., Coleman, D. and Wiles, J. 2007. Differences in efficiency between trained and recreational cyclists. Applied Physiology, Nutrition and Metabolism. 32 (6), pp. 1036-1042. https://doi.org/10.1139/H07-070
Reliability of sprint test indices in well-trained cyclists
Coleman, D., Wiles, J., Nunn, M. and Smith, M. 2005. Reliability of sprint test indices in well-trained cyclists. International Journal of Sports Medicine. 26 (5), pp. 383-387. https://doi.org/10.1055/s-2004-821226
Power output measurement during treadmill cycling
Coleman, D., Wiles, J., Davison, R., Smith, M. and Swaine, I. 2007. Power output measurement during treadmill cycling. International Journal of Sports Medicine. 28 (6), pp. 525-530. https://doi.org/10.1055/s-2006-955888
Interventions in forensic psychiatry: the caregiver's perspective
MacInnes, D. 2000. Interventions in forensic psychiatry: the caregiver's perspective. British Journal of Nursing. 9 (15), pp. 992-8.