Neuroimaging glutamatergic mechanisms differentiating antipsychotic treatment-response

Journal article

Mouchlianitis, Elias D, Vanes, Lucy D, Tracy, Derek K, Fett, Anne-Katherin, Joyce, Daniel and Shergill, Sukhi S 2023. Neuroimaging glutamatergic mechanisms differentiating antipsychotic treatment-response. Scientific Reports. 13 (1), p. 8938. https://doi.org/10.1038/s41598-022-26702-0
AuthorsMouchlianitis, Elias D, Vanes, Lucy D, Tracy, Derek K, Fett, Anne-Katherin, Joyce, Daniel and Shergill, Sukhi S
AbstractGlutamatergic dysfunction is associated with failure to respond to antipsychotic medication in individuals with schizophrenia. Our objective was to combine neurochemical and functional brain imaging methods to investigate glutamatergic dysfunction and reward processing in such individuals compared with those with treatment responsive schizophrenia, and healthy controls. 60 participants played a trust task, while undergoing functional magnetic resonance imaging: 21 classified as having treatment-resistant schizophrenia, 21 patients with treatment-responsive schizophrenia, and 18 healthy controls. Proton magnetic resonance spectroscopy was also acquired to measure glutamate in the anterior cingulate cortex. Compared to controls, treatment responsive and treatment-resistant participants showed reduced investments during the trust task. For treatment-resistant individuals, glutamate levels in the anterior cingulate cortex were associated with signal decreases in the right dorsolateral prefrontal cortex when compared to those treatment-responsive, and with bilateral dorsolateral prefrontal cortex and left parietal association cortex when compared to controls. Treatment-responsive participants showed significant signal decreases in the anterior caudate compared to the other two groups. Our results provide evidence that glutamatergic differences differentiate treatment resistant and responsive schizophrenia. The differentiation of cortical and sub-cortical reward learning substrates has potential diagnostic value. Future novel interventions might therapeutically target neurotransmitters affecting the cortical substrates of the reward network. [Abstract copyright: © 2023. The Author(s).]
KeywordsNeuroimaging; Humans; Antipsychotic agents ; Prefrontal cortex; Magnetic resonance imaging; Gyrus cinguli; Glutamic Acid
Year2023
JournalScientific Reports
Journal citation13 (1), p. 8938
PublisherCambridge University Press
ISSN2045-2322
Digital Object Identifier (DOI)https://doi.org/10.1038/s41598-022-26702-0
Official URLhttps://doi.org/10.1192/bjo.2022.577
FunderDepartment of Health
Publication dates
Online02 Jun 2023
Publication process dates
Deposited10 Oct 2022
Accepted19 Dec 2022
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