Neuroimaging oxytocin modulation of social reward learning in schizophrenia.

Journal article


Mouchlianitis, Elias D, Tracy, D., Wigton, Rebekah, Vanes, Lucy D, Fett, A. and Shergill, Sukhi S 2022. Neuroimaging oxytocin modulation of social reward learning in schizophrenia. BJPsych Open. 8 (5), p. e175. https://doi.org/10.1192/bjo.2022.577
AuthorsMouchlianitis, Elias D, Tracy, D., Wigton, Rebekah, Vanes, Lucy D, Fett, A. and Shergill, Sukhi S
AbstractConventional pharmacological approaches have limited effectiveness for schizophrenia. There is interest in the application of oxytocin, which is involved in social cognition. Clinical trials have yielded mixed results, with a gap in understanding neural mechanisms. To evaluate the behavioural impact of oxytocin administration on a social learning task in individuals with schizophrenia, and elucidate any differential neural activity produced. We recruited 20 clinically stable right-handed men diagnosed with schizophrenia or schizoaffective disorder. In a double-blind cross-over randomised controlled study, 40 IU of oxytocin or placebo were administered before functional magnetic resonance imaging of participants playing a multi-round economic exchange game of trust. Participants had the role of investors (investment trials) receiving repayment on their investments (repayment trials), playing one session against a computer and a second against a player believed to be human. During investment trials, oxytocin increased neural signalling in the right lateral parietal cortex for both human and computer player trials, and attenuated signalling in the right insula for human player trials. For repayment trials, oxytocin elicited signal increases in left insula and left ventral caudate, and a signal decrease in right amygdala during the human player trials; conversely it resulted in right dorsal caudate activation during the computer player trials. We did not find a significant change in behavioural performance associated with oxytocin administration, or any associations with symptoms. During a social learning task oxytocin modulates cortical and limbic substrates of the reward-processing network. These perturbations can be putatively linked to the pathoaetiology of schizophrenia.
Keywordsschizophrenia; psychosis; fMRI; trust; Oxytocin
Year2022
JournalBJPsych Open
Journal citation8 (5), p. e175
PublisherCambridge University Press
ISSN2056-4724
Digital Object Identifier (DOI)https://doi.org/10.1192/bjo.2022.577
https://doi.org/S2056472422005774
Official URLhttps://doi.org/10.1192/bjo.2022.577
Publication dates
Online26 Sep 2022
Publication process dates
Deposited10 Oct 2022
Publisher's version
License
Output statusPublished
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Publications router: Date 2022-09-26 of type 'publication_date' with format 'electronic' included in notification

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