Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics.

Journal article

Padinharayil, Hafiza, Varghese, Jinsu, John, Mithun Chacko, Rajanikant, Golgodu Krishnamurthy, Wilson, Cornelia M, Al-Yozbaki, Minnatallah, Renu, Kaviyarasi, Dewanjee, Saikat, Sanyal, Rupa, Dey, Abhijit, Mukherjee, Anirban Goutam, Wanjari, Uddesh Ramesh, Gopalakrishnan, Abilash Valsala and George, Alex 2022. Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics. Genes & Diseases. 10 (3), pp. 960-989. https://doi.org/10.1016/j.gendis.2022.07.023
AuthorsPadinharayil, Hafiza, Varghese, Jinsu, John, Mithun Chacko, Rajanikant, Golgodu Krishnamurthy, Wilson, Cornelia M, Al-Yozbaki, Minnatallah, Renu, Kaviyarasi, Dewanjee, Saikat, Sanyal, Rupa, Dey, Abhijit, Mukherjee, Anirban Goutam, Wanjari, Uddesh Ramesh, Gopalakrishnan, Abilash Valsala and George, Alex
AbstractContinuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) provides the foundation for therapeutic advances by promoting molecular targeted and immunotherapies and ensuring accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention, diagnosis, and management, supporting health-care interventions. Global cancer mortality projections from 2016 to 2060 show that cancer will overtake ischemic heart diseases (IHD) as the leading cause of death (18.9 million) immediately after 2030, surpassing non-small cell lung cancer (NSCLC), which accounts for 85 percent of lung cancers. The clinical stage at the diagnosis is the main prognostic factor in NSCLC therapies. Advanced early diagnostic methods are essential as the initial stages of cancer show reduced mortality compared to the advanced stages. Sophisticated approaches to proper histological classification and NSCLC management have improved clinical efficiency. Although immune checkpoint inhibitors (ICIs) and targeted molecular therapies have refined the therapeutic management of late-stage NSCLC, the specificity and sensitivity of cancer biomarkers should be improved by focusing on prospective studies, followed by their use as therapeutic tools. The liquid biopsy candidates such as circulating tumor cells (CTCs), circulating cell-free tumor DNA (cfDNA), tumor educated platelets (TEP), and extracellular vesicles (EVs) possess cancer-derived biomolecules and aid in tracing: driver mutations leading to cancer, acquired resistance caused by various generations of therapeutic agents, refractory disease, prognosis, and surveillance. [Abstract copyright: © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.]
KeywordsEpidemiology; Targeted therapy; NSCLC; Histology; Clinical trial; Biomarker; Liquid biopsy
Year2022
JournalGenes & Diseases
Journal citation10 (3), pp. 960-989
PublisherElsevier
ISSN2352-3042
Digital Object Identifier (DOI)https://doi.org/10.1016/j.gendis.2022.07.023
Official URLhttps://www.sciencedirect.com/science/article/pii/S2352304222002227
Publication dates
Online23 Aug 2022
Publication process dates
Accepted27 Jul 2022
Deposited26 Jul 2023
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