Extracellular vesicles, stem cells and the role of miRNAs in neurodegeneration

Journal article

Belkozhayev, Ayaz M., Al-Yozbaki, Minnatallah, George, Alex, Ye Niyazova, Raigul, Sharipov, Kamalidin O., Byrne, Lee J. and Wilson, Cornelia M. 2021. Extracellular vesicles, stem cells and the role of miRNAs in neurodegeneration. Current Neuropharmacology. 20 (8), pp. 1450-1478. https://doi.org/10.2174/1570159x19666210817150141
AuthorsBelkozhayev, Ayaz M., Al-Yozbaki, Minnatallah, George, Alex, Ye Niyazova, Raigul, Sharipov, Kamalidin O., Byrne, Lee J. and Wilson, Cornelia M.
AbstractAbstract: There are different modalities of intercellular communication governed by cellular homeostasis. In this review, we will explore one of these forms of communication called extracellular vesicles (EVs). These vesicles are released by all cells in the body and are heterogeneous in nature. The primary function of EVs is to share information through their cargo consisting of proteins, lipids and nucleic acids (mRNA, miRNA, dsDNA etc.) with other cells, which have a direct consequence on their microenvironment. We will focus on the role of EVs of mesenchymal stem cells (MSCs) in the nervous system and how these participate in intercellular communication to maintain physiological function and provide neuroprotection. However, deregulation of this same communication system could play a role in several neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, multiple sclerosis, prion disease and Huntington’s disease. The release of EVs from a cell provides crucial information to what is happening inside the cell and thus could be used in diagnostics and therapy. We will discuss and explore new avenues for the clinical applications of using engineered MSC-EVs and their potential therapeutic benefit in treating neurodegenerative diseases.
KeywordsNeurology; Stem cells; Neurodegeneration; Alzheimer’s disease; Amyotrophic lateral sclerosis; Extracellular vesicles; Huntington’s disease; Parkinson’s disease; miRNA; Multiple sclerosis; Prion disease
Year2021
JournalCurrent Neuropharmacology
Journal citation20 (8), pp. 1450-1478
PublisherBentham Science Publishers
ISSN1570-159X
Digital Object Identifier (DOI)https://doi.org/10.2174/1570159x19666210817150141
Official URLhttps://www.eurekaselect.com/195709/article
Publication dates
Print17 Aug 2021
Online17 Aug 2021
Publication process dates
Accepted14 Jun 2021
Deposited11 Oct 2021
Accepted author manuscript
License
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/8y93x/extracellular-vesicles-stem-cells-and-the-role-of-mirnas-in-neurodegeneration

Download files

Accepted author manuscript
Belkozhayev et al., 2021 complete.pdf
License: CC BY-NC-ND 4.0

  • 76
    total views
  • 99
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Investigating the effect of mesoporous silica nanoparticles as a drug delivery system for Withaferin A in the treatment of Lung Cancer
Holder, J., Wilson, C., Bertolo-Pardo, E., Byrne, L., Oliveira, E. and Trim, C. 2024. Investigating the effect of mesoporous silica nanoparticles as a drug delivery system for Withaferin A in the treatment of Lung Cancer.
Investigating the effect of silica nanoparticles as a drug delivery system for Doxorubicin in the treatment of lung cancer
Holder, J., Wilson, C., Bertolo-Pardo, E., Oliveira, E., Byrne, L. and Trim, C. 2024. Investigating the effect of silica nanoparticles as a drug delivery system for Doxorubicin in the treatment of lung cancer.
AI is a viable alternative to high throughput screening: a 318-target study
Wilson, C.M., Byrne, L., Al-Yozbaki, M. and The Atomwise AIMS Program 2024. AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports. https://doi.org/10.1038/s41598-024-54655-z
Mesenchymal stem cell-derived exosomes: Characteristics and applications in disease pathology and management.
Padinharayil, H., Varghese, J., Wilson, C. and George, A. 2024. Mesenchymal stem cell-derived exosomes: Characteristics and applications in disease pathology and management. Life Sciences. 342 (122542). https://doi.org/10.1016/j.lfs.2024.122542
Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options.
Panneerselvam, S., Wilson, Cornelia, Kumar, Prem, Abirami, Dinu, Pamarthi, Jayakrishna, Reddy, Mettu Srinivas and Varghese, Joy 2023. Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options. Cell Adhesion and Migration. 17 (1), pp. 1-21. https://doi.org/10.1080/19336918.2023.2258539
The use of nanoparticles for targeted drug delivery in non-small cell lung cancer.
Holder, Jessica E, Ferguson, Christopher, Oliveira, Elisabete, Lodeiro, Carlos, Trim, Carol M, Byrne, Lee J, Bertolo, Emilia and Wilson, Cornelia M 2023. The use of nanoparticles for targeted drug delivery in non-small cell lung cancer. Frontiers in Oncology. 13, p. 1154318. https://doi.org/10.3389/fonc.2023.1154318
Stochastic Variation in DNA Methylation Modulates Nucleosome Occupancy and Alternative Splicing in <i>Arabidopsis thaliana</i>.
Jabre, Ibtissam, Chaudhary, S., Wilson, C., Staiger, D. and Syed, N. 2022. Stochastic Variation in DNA Methylation Modulates Nucleosome Occupancy and Alternative Splicing in <i>Arabidopsis thaliana</i>. Plants. 11 (9), p. 1105. https://doi.org/10.3390/plants11091105
Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics.
Padinharayil, Hafiza, Varghese, Jinsu, John, Mithun Chacko, Rajanikant, Golgodu Krishnamurthy, Wilson, Cornelia M, Al-Yozbaki, Minnatallah, Renu, Kaviyarasi, Dewanjee, Saikat, Sanyal, Rupa, Dey, Abhijit, Mukherjee, Anirban Goutam, Wanjari, Uddesh Ramesh, Gopalakrishnan, Abilash Valsala and George, Alex 2022. Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics. Genes & Diseases. 10 (3), pp. 960-989. https://doi.org/10.1016/j.gendis.2022.07.023
The role of nanotechnology for diagnostic and therapy strategies in lung cancer
Holder, J., Al-Yozbaki, M. and Wilson, C. 2022. The role of nanotechnology for diagnostic and therapy strategies in lung cancer. in: Medical Radiology Berlin, Heidelberg Springer. pp. 1-18
Proteomic analysis of the extracellular vesicles derived from human hip joints affected by osteoarthritis
Tirnoveanu, A., Ahmed, S., Webb, R., Howland, K., Hurt, A., Wilson, C. and Mylona, A. 2022. Proteomic analysis of the extracellular vesicles derived from human hip joints affected by osteoarthritis.
Bioinformatics analysis of the interaction of miRNAs and piRNAs with human mRNA genes having di- and trinucleotide repeats
Belkozhayev, A., Niyazova, Raigul, Wilson, C., Jainakbayev, Nurlan, Pyrkova, A., Ashirbekov, Y., Akimniyazova, Aigul, Sharipov, K. and Ivashchenko, A. 2022. Bioinformatics analysis of the interaction of miRNAs and piRNAs with human mRNA genes having di- and trinucleotide repeats. Genes. 13 (5), p. 800. https://doi.org/10.3390/genes13050800
Phytomedicinal therapeutics for male infertility: critical insights and scientific updates.
Ramgir, Shalaka S, Renu, Kaviyarasi, Vellingiri, Balachandar, George, Alex, Tirupapuliyur, Damodaran, Thiagarajan, Padma and Valsala Gopalakrishnan, A. 2022. Phytomedicinal therapeutics for male infertility: critical insights and scientific updates. Journal of Natural Medicines. https://doi.org/10.1007/s11418-022-01619-0
Exploring the cytotoxic mechanisms of Pediocin PA-1 towards HeLa and HT29 cells by comparison to known bacteriocins: Microcin E492, enterocin heterodimer and Divercin V41.
Buss, G. and Wilson, C. 2021. Exploring the cytotoxic mechanisms of Pediocin PA-1 towards HeLa and HT29 cells by comparison to known bacteriocins: Microcin E492, enterocin heterodimer and Divercin V41. PLoS ONE. 16 (9), p. e0251951. https://doi.org/10.1371/journal.pone.0251951
The undiscovered potential of essential oils for treating SARS-CoV-2 (COVID-19)
Wilkin, P. J., Al-Yozbaki, M., George, A., Gupta, G.K. and Wilson, C.M. 2021. The undiscovered potential of essential oils for treating SARS-CoV-2 (COVID-19). Current Pharmaceutical Design. 26 (41), pp. 5261-5277. https://doi.org/10.2174/1381612826666201015154611
Balancing neurotrophin pathway and sortilin function: its role in human disease
Al-Yozbaki, M., Acha-Sagredo, A., George, A., Liloglou, T. and Wilson, C.M. 2021. Balancing neurotrophin pathway and sortilin function: its role in human disease. Biochim Biophys Acta Rev Cancer. 1874 (2). https://doi.org/10.1016/j.bbcan.2020.188429
Targeting DNA methyltransferases in non-small-cell lung cancer
Al-Yozbaki, M., Jabre, I., Syed, N. and Wilson, C. 2021. Targeting DNA methyltransferases in non-small-cell lung cancer. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2021.01.005
Therapeutic potential of natural compounds in lung cancer
Al-Yozbaki, M., Wilkin, P., Gupta, G. and Wilson, C. 2021. Therapeutic potential of natural compounds in lung cancer. Current Medicinal Chemistry. 28 (39), pp. 7988-8002. https://doi.org/10.2174/0929867328666210322103906
Utilisation of compounds from venoms in drug discovery
Trim, Carol M, Byrne, Lee J and Trim, Steven A 2021. Utilisation of compounds from venoms in drug discovery. Progress in Medicinal Chemistry. 60, pp. 1-66. https://doi.org/S0079-6468(21)00001-1
Differential nucleosome occupancy modulates alternative splicing in Arabidopsis thaliana
Jabre, I., Chaudhary, S., Guo, W., Kalyna, M., Reddy, A. S. N., Chen, W., Zhang, R., Wilson, C. and Syed, N. 2020. Differential nucleosome occupancy modulates alternative splicing in Arabidopsis thaliana. New Phytologist. https://doi.org/10.1111/nph.17062
Applications and strategies in nanodiagnosis and nanotherapy in lung cancer
Woodman, C., Vundu, G., George, A. and Wilson, C. 2020. Applications and strategies in nanodiagnosis and nanotherapy in lung cancer. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2020.02.009
Does co-transcriptional regulation of alternative splicing mediate plant stress responses?
Jabre, I., Reddy, A., Kalyna, M., Chaudhary, S., Khokhar, W., Byrne, L., Wilson, C. and Syed, N. 2019. Does co-transcriptional regulation of alternative splicing mediate plant stress responses? Nucleic Acids Research. 47 (6), pp. 2716-2726. https://doi.org/10.1093/nar/gkz121
Alternative splicing and protein diversity: plants versus animals
Chaudhry, S., Khokhar, W., Jabre, I., Reddy, A., Byrne, L., Wilson, C. and Syed, N. 2019. Alternative splicing and protein diversity: plants versus animals. Frontiers in Plant Science. 10 (708). https://doi.org/10.3389/fpls.2019.00708
Integrating research and knowledge exchange in the Science Undergraduate Curriculum: embedding employability through research-involved teaching
Harvey, C., Bertolo-Pardo, E. and Byrne, L. 2017. Integrating research and knowledge exchange in the Science Undergraduate Curriculum: embedding employability through research-involved teaching. in: Renes, S. (ed.) Global Voices in Higher Education In-Tech. pp. 111-128
Genome-wide identification of splicing quantitative trait loci (sQTLs) in diverse ecotypes of Arabidopsis thaliana
Khokhar, W., Hassan, M., Reddy, A., Chaudhary, S., Jabre, I., Byrne, L. and Syed, N. 2019. Genome-wide identification of splicing quantitative trait loci (sQTLs) in diverse ecotypes of Arabidopsis thaliana. Frontiers in Plant Science. 10 (1160). https://doi.org/10.3389/fpls.2019.01160
‘Something in the way she moves’: The functional significance of flexibility in the multiple roles of protein disulfide isomerase (PDI)
Freedman, R., Desmond, J., Byrne, L., Heal, J., Howard, M., Sanghera, N., Walker, K., Wallis, A., Wells, S., Williamson, R. and Romer, R. 2017. ‘Something in the way she moves’: The functional significance of flexibility in the multiple roles of protein disulfide isomerase (PDI). Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1865 (11 (A)), pp. 1383-1394. https://doi.org/10.1016/j.bbapap.2017.08.014
The role of endoproteolytic processing in neurodegeneration
Wilson, C., Mushtaq, G., Kamal, M. and Terro, F. 2016. The role of endoproteolytic processing in neurodegeneration. CNS and Neurological Disorders Drug Targets. 15. https://doi.org/10.2174/1871527315666160922163511
Challenges and strategies in precision medicine for non-small cell lung cancer
Wilson, C., Al-Akhrass, A. and Sacco, J. 2016. Challenges and strategies in precision medicine for non-small cell lung cancer. Current Pharmaceutical Design. 22. https://doi.org/10.2174/1381612822666160603014932
Winter Aconite (Eranthis hyemalis) Lectin as a cytotoxic effector in the lifecycle of Caenorhabditis elegans
McConnell, M., Lisgarten, D., Byrne, L., Harvey, S. and Bertolo-Pardo, E. 2015. Winter Aconite (Eranthis hyemalis) Lectin as a cytotoxic effector in the lifecycle of Caenorhabditis elegans. PeerJ. https://doi.org/10.7717/peerj.1206
Cell division is essential for elimination of the yeast [PSI+] prion by guanidine hydrochloride
Byrne, L., Cox, B., Coleman, D., Ridout, M., Morgan, B. and Tuiteq, M. 2007. Cell division is essential for elimination of the yeast [PSI+] prion by guanidine hydrochloride. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 104 (28), pp. 11688-11693. https://doi.org/10.1073/pnas.0701392104
Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors
Wilson, C., Naves, T., Vincent, F., Lalloue, F. and Jauberteau, M. 2015. Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.
Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.
Wilson, C., Naves, T., Vincent, F., Melloni, B., Bonnaud, F., Lalloue, F. and Jauberteau, M. 2014. Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors. Journal of Cell Science (JCS). 127 (18), pp. 3983-3997. https://doi.org/10.1242/jcs.149336
The number and transmission of [PSI+] prion seeds (Propagons) in the yeast Saccharomyces cerevisiae
Byrne, L., Cole, D., Cox, B., Ridout, M., Morgan, B. and Tuite, M. 2009. The number and transmission of [PSI+] prion seeds (Propagons) in the yeast Saccharomyces cerevisiae. PLoS ONE. 4 (3), p. e4670. https://doi.org/10.1371/journal.pone.0004670
Mapping of the ligand-binding site on the b′ domain of human PDI: interaction with peptide ligands and the x-linker region
Byrne, L., Sidhu, A., Wallis, A., Ruddock, L., Freedman, R., Howard, M. and Williamson, R. 2009. Mapping of the ligand-binding site on the b′ domain of human PDI: interaction with peptide ligands and the x-linker region. Biochemical Journal. 423 (2), pp. 209-217. https://doi.org/10.1042/BJ20090565
The ligand-binding b' domain of human protein disulphide-isomerase mediates homodimerization
Wallis, A., Sidhu, A., Byrne, L., Howard, M., Ruddock, L., Williamson, R. and Freedman, R. 2009. The ligand-binding b' domain of human protein disulphide-isomerase mediates homodimerization. Protein Science. 18 (12), pp. 2569-2577. https://doi.org/10.1002/pro.270