Therapeutic potential of natural compounds in lung cancer

Journal article


Al-Yozbaki, M., Wilkin, P.J., Wilson, C.M. and Gupta, G.K. 2021. Therapeutic potential of natural compounds in lung cancer. Current Medicinal Chemistry. https://doi.org/10.2174/0929867328666210322103906
AuthorsAl-Yozbaki, M., Wilkin, P.J., Wilson, C.M. and Gupta, G.K.
Abstract

Lung cancer is a leading cause of cancer deaths worldwide. The management of lung cancer treatment is often ineffective as a result of the development of drug resistance, reactions to treatment, drug-drug interactions or non-specific targeting of the anti-cancer drugs. Natural compounds show promise and potential activity in lung cancer with very few side effects. While, the combinatorial action of an anti-cancer drug with a natural compound provide synergistic action which help to boost the overall therapeutic action against cancer cells. In cancer, there is a dysregulation of apoptosis which facilitates the cancer cell to survive resulting in progression of the cancer. Many cancer drugs cause mutations of genes that regulate the cancer which should kill the cancer cell but lead to chemoresistance. There are many natural compounds that could specifically target different cell signalling pathways associated with cancer progression to provide a cytotoxic effect in the target cell. The importance of these compounds is emerging in many therapies developed with dual action often including a natural compound. In this review, we present a selection of these natural compounds and how they target lung cancer cells with a focus on the cell signalling pathways. Further work is required to delineate the potential action of natural compounds in the treatment against cancer.

KeywordsApoptosis; Lung cancer; Natural compounds; Therapy
Year2021
JournalCurrent Medicinal Chemistry
PublisherBentham Science Publishers
ISSN0929-8673
Digital Object Identifier (DOI)https://doi.org/10.2174/0929867328666210322103906
Official URLhttps://www.eurekaselect.com/node/192375/article/therapeutic-potential-of-natural-compounds-in-lung-cancer
Publication dates
Print21 Mar 2021
Publication process dates
Accepted21 Mar 2021
Deposited30 Jul 2021
Accepted author manuscript
License
File Access Level
Open
Output statusIn press
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