Targeting DNA methyltransferases in non-small-cell lung cancer

Journal article


Al-Yozbaki, M., Jabre, I., Syed, N. and Wilson, C. 2021. Targeting DNA methyltransferases in non-small-cell lung cancer. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2021.01.005
AuthorsAl-Yozbaki, M., Jabre, I., Syed, N. and Wilson, C.
Abstract

Despite the advances in treatment using chemotherapy or targeted therapies, due to static survival rates, non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths worldwide. Epigenetic-based therapies have been developed for NSCLC by targeting DNA methyltransferases (DNMTs) and histone-modifying enzymes. However, treatment using single epigenetic agents on solid tumours has been inadequate; whereas, treatment with a combination of DNMTs inhibitors with chemotherapy and immunotherapy has shown great promise. Dietary sources of phytochemicals could also inhibit DNMTs and cancer stem cells, representing a novel and promising way to prevent and treat cancer. Herein, we will discuss the different DNMTs, DNA methylation profiling in NSCLC as well as current demethylating agents in ongoing clinical trials. Therefore, providing a concise overview of future developments in the field of epigenetic therapy in NSCLC.

KeywordsDNA methylation; DNA methyltransferases; Demethylating agents; Dietary phytochemicals; Non-small cell lung cancer
Year2021
JournalSeminars in Cancer Biology
PublisherElsevier
ISSN1044-579X
Digital Object Identifier (DOI)https://doi.org/10.1016/j.semcancer.2021.01.005
Official URLhttps://www.sciencedirect.com/science/article/pii/S1044579X21000110?via%3Dihub
Publication dates
Print21 Jan 2021
Publication process dates
Accepted17 Jan 2021
Deposited30 Jul 2021
Accepted author manuscript
License
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Open
Output statusIn press
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