The role of endoproteolytic processing in neurodegeneration

Journal article


Wilson, C., Mushtaq, G., Kamal, M. and Terro, F. 2016. The role of endoproteolytic processing in neurodegeneration. CNS and Neurological Disorders Drug Targets. 15. https://doi.org/10.2174/1871527315666160922163511
AuthorsWilson, C., Mushtaq, G., Kamal, M. and Terro, F.
Abstract

Endoproteolysis is a normal post-translational process in the eukaryotic cell that had played a role early on in protein evolution allowing protein catabolism and the generation of amino acids. Endoproteolytic cleavage regulates many crucial cellular processes including the activity of many proteins, their protein-protein interactions and the amplification of cell signals. Not surprisingly, disruption or alternation of endoproteolytic cleavage maybe the root cause of many human diseases such as Alzheimer’s disease, Huntington’s disease and prion diseases. Most neurodegenerative diseases (ND) are caused by the build-up of misfolded proteins and the promotion of aggregation events. A common event that occurs in these ND is the alteration of endoproteolytic cleavage due to genetic mutations of the associated-proteases or in the target substrate. Endoproteolytic cleavage resulting in protein truncation has significant effects on the structure and function of a protein representing a common feature of ND. In this review, we will discuss the endoproteolytic cleavage events that lead to ND, namely Alzheimer’s disease, Huntington’s disease and prion diseases.

Year2016
JournalCNS and Neurological Disorders Drug Targets
Journal citation15
PublisherBentham Science Publishers
ISSN1871-5273
Digital Object Identifier (DOI)https://doi.org/10.2174/1871527315666160922163511
Publication dates
Online22 Sep 2016
Publication process dates
Deposited21 Sep 2016
Completed31 Jan 2016
Accepted21 Sep 2016
Accepted author manuscript
Output statusPublished
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