Conotoxins: structure, therapeutic potential and pharmacological applications.

Journal article


Mir, R., Karim, S., Kamal, M., Wilson, C. and Mirza, Z. 2016. Conotoxins: structure, therapeutic potential and pharmacological applications. Current Pharmaceutical Design. 22 (5), pp. 582-589. https://doi.org/10.2174/1381612822666151124234715
AuthorsMir, R., Karim, S., Kamal, M., Wilson, C. and Mirza, Z.
Abstract

Cone snails, also known as marine gastropods, from Conus genus produce in their venom a diverse range of small pharmacologically active structured peptides called conotoxins. The cone snail venoms are widely unexplored arsenal of toxins with therapeutic and pharmacological potential, making them a treasure trove of ligands and peptidic drug leads. Conotoxins are small disulfide bonded peptides, which act as remarkable selective inhibitors and modulators of ion channels (calcium, sodium, potassium), nicotinic acetylcholine receptors, noradrenaline transporters, N-methyl-D-aspartate receptors, and neurotensin receptors. They are highly potent and specific against several neuronal targets making them valuable as research tools, drug leads and even therapeutics. In this review, we discuss their gene superfamily classification, nomenclature, post-translational modification, structural framework, pharmacology and medical applications of the active conopeptides. We aim to give an overview of their structure and therapeutic potential. Understanding these aspects of conopeptides will help in designing more specific peptidic analogues.

Year2016
JournalCurrent Pharmaceutical Design
Journal citation22 (5), pp. 582-589
PublisherBentham Science Publishers
ISSN1381-6128
Digital Object Identifier (DOI)https://doi.org/10.2174/1381612822666151124234715
Publication dates
Print01 Feb 2016
Publication process dates
Deposited12 Jul 2016
Accepted10 Dec 2015
Accepted author manuscript
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/87w79/conotoxins-structure-therapeutic-potential-and-pharmacological-applications

Download files


Accepted author manuscript
  • 33
    total views
  • 434
    total downloads
  • 1
    views this month
  • 14
    downloads this month

Export as