Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options.

Journal article


Panneerselvam, S., Wilson, Cornelia, Kumar, Prem, Abirami, Dinu, Pamarthi, Jayakrishna, Reddy, Mettu Srinivas and Varghese, Joy 2023. Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options. Cell Adhesion and Migration. 17 (1), pp. 1-21. https://doi.org/10.1080/19336918.2023.2258539
AuthorsPanneerselvam, S., Wilson, Cornelia, Kumar, Prem, Abirami, Dinu, Pamarthi, Jayakrishna, Reddy, Mettu Srinivas and Varghese, Joy
AbstractHepatocellular carcinoma (HCC) is the seventh most highly prevalent malignant tumor globally and the second most common cause of mortality. HCC develops with complex pathways that occur through multistage biological processes. Non-alcoholic fatty liver disease, metabolic-associated fatty liver disease, alcoholic liver disease, autoimmune hepatitis, hepatitis B, and hepatitis C are the causative etiologies of HCC. HCC develops as a result of epigenetic changes, protein-coding gene mutations, and altered signaling pathways. Biomarkers and potential therapeutic targets for HCC open up new possibilities for treating the disease. Immune checkpoint inhibitors are included in the treatment options in combination with molecular targeted therapy.
KeywordsImmunotherapy; Cell Signaling Pathways; Circulating Tumour Cell; Hcc Biomarkers; Multi-Omics Technology; Humans; Carcinoma, Hepatocellular; Liver Neoplasms; Mutation; Molecular Targeted Therapy
Year2023
JournalCell Adhesion and Migration
Journal citation17 (1), pp. 1-21
ISSN1933-6918
1933-6926
Digital Object Identifier (DOI)https://doi.org/10.1080/19336918.2023.2258539
Official URLhttps://www.tandfonline.com/doi/full/10.1080/19336918.2023.2258539
Funderreported that there is no funding associated with the work featured in this article
Publication dates
Online19 Sep 2023
Print01 Dec 2023
Publication process dates
Accepted08 Sep 2023
Deposited28 Sep 2023
Output statusPublished
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