Construction of a prognostic survival model with tumor immune-related genes for breast cancer.
Journal article
Guo, Shuai, Guo, Liang, Li, Jiangyun, Li, Jianguo, Zhang, Qiqi, Zhang, Jing, Boussios, Stergios and Toi, Masakazu 2024. Construction of a prognostic survival model with tumor immune-related genes for breast cancer. Translational Cancer Research. 13 (12), pp. 6919-6935. https://doi.org/10.21037/tcr-24-2137
| Authors | Guo, Shuai, Guo, Liang, Li, Jiangyun, Li, Jianguo, Zhang, Qiqi, Zhang, Jing, Boussios, Stergios and Toi, Masakazu |
|---|---|
| Abstract | Numerous studies have demonstrated that immune cell infiltration is a significant predictor in the prognosis of those with breast cancer. This study aimed to develop a prognostic model for undifferentiated breast cancer using immune-related markers. Differentially expressed genes (DEGs) and prognostic factors were identified from The Cancer Genome Atlas (TCGA) database. Cancer immune-associated genes were filtered using the GeneCards database. Least absolute shrinkage and selection operator (LASSO) and Cox proportional hazards regression were employed to select prognostic indicators. The single-sample gene set enrichment analysis (ssGSEA) algorithm and the CIBERSORT algorithm were used to analyze the correlation of prognostic indicators with immune cells in breast cancer. We identified six tumor immune-related genes, including zic family member 2 ( ), solute carrier family 7 member 5 ( ), forkhead box J1 ( ), C-X-C motif chemokine ligand 9 ( ), tumor necrosis factor receptor superfamily member 18 ( ), and serine protease 2 ( ), for the development of a prognostic model for patients with breast cancer. Notably, the results of the correlation analysis indicated that was associated with antitumor immune cells, including CD8 T cells, cytotoxic cells, M1 macrophages, and activated memory CD4 T cells, and with the enrichment of natural killer (NK) CD56dim cells. Furthermore, exhibited a significant negative association with the tumor-promoting M2 macrophage phenotype. Our study established a six-gene model for predicting breast cancer prognosis. Furthermore, we unexpectedly discovered that is integral to immune infiltration in breast cancer and may serve as a critical biomarker for evaluating immune response and therapeutic efficacy in breast cancer treatment. [Abstract copyright: 2024 AME Publishing Company. All rights reserved.] |
| Keywords | C-X-C motif chemokine ligand 9 (CXCL9); Immune infiltration; Breast cancer; Prognostic model; Immunomodulators |
| Year | 2024 |
| Journal | Translational Cancer Research |
| Journal citation | 13 (12), pp. 6919-6935 |
| Publisher | AME Publishing |
| ISSN | 2219-6803 |
| Digital Object Identifier (DOI) | https://doi.org/10.21037/tcr-24-2137 |
| Official URL | https://tcr.amegroups.org/article/view/94699/html |
| Publication dates | |
| Online | 27 Dec 2024 |
| Publication process dates | |
| Accepted | 18 Dec 2024 |
| Deposited | 30 Jan 2025 |
| Publisher's version | License File Access Level Open |
| Output status | Published |
| Additional information | Publications router. |
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https://repository.canterbury.ac.uk/item/9q330/construction-of-a-prognostic-survival-model-with-tumor-immune-related-genes-for-breast-cancer
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