Antibody drug conjugates in urological cancers: A review of the current landscape

Journal article

Ghose, Aruni, Lapitan, Patricia, Apte, Vedika, Ghosh, Adheesh, Kandala, Abhinav, Basu, Sreejana, Parkes, Jo, Shinde, Sayali D, Boussios, Stergios, Sharma, Anand, Das, Prantik, Vasdev, Nikhil, Rebuzzi, Sara E, Ürün, Yüksel, Kanesvaran, Ravindran, Maniam, Akash and Banna, Giuseppe L 2024. Antibody drug conjugates in urological cancers: A review of the current landscape. Current Oncology Reports. https://doi.org/10.1007/s11912-024-01524-7
AuthorsGhose, Aruni, Lapitan, Patricia, Apte, Vedika, Ghosh, Adheesh, Kandala, Abhinav, Basu, Sreejana, Parkes, Jo, Shinde, Sayali D, Boussios, Stergios, Sharma, Anand, Das, Prantik, Vasdev, Nikhil, Rebuzzi, Sara E, Ürün, Yüksel, Kanesvaran, Ravindran, Maniam, Akash and Banna, Giuseppe L
AbstractOur review delves into the progress across urological malignancies and discusses ongoing challenges and future directions in antibody-drug conjugate (ADC) development, emphasising their transformative potential in cancer care. ADCs have advanced from hematologic to solid tumours, notably in breast cancer, and are now pivotal in metastatic urological cancers as both monotherapies and in combination regimens, underscored by the FDA's approval of enfortumab vedotin and sacituzumab govitecan for metastatic urothelial cancer. Progress in metastatic prostate cancer, particularly with ADCs targeting PSMA and STEAP1, is noteworthy, although renal cell cancer presents ongoing challenges. There is a continual search for agents in the metastatic, relapsed testicular cancer landscape. ADCs have emerged as a pivotal innovation in oncology, blending targeted antibody therapy with potent cytotoxic drugs, significantly advancing treatment options for urological malignancies. [Abstract copyright: © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.]
KeywordsProstate; Testicular; Cancer; Urology; Urothelial; Antibody drug conjugate; Renal; Chemotherapy
Year2024
JournalCurrent Oncology Reports
PublisherSpringer
ISSN1534-6269
Digital Object Identifier (DOI)https://doi.org/10.1007/s11912-024-01524-7
Official URLhttps://link.springer.com/article/10.1007/s11912-024-01524-7
Publication dates
Online23 Apr 2024
Publication process dates
Accepted25 Mar 2024
Deposited09 May 2024
Output statusPublished
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