Clinical challenges in the management of malignant ovarian germ cell tumours

Journal article

Iqra Saani, Nitish Raj, Raja Sood, Shahbaz Ansari, Haider Abbas Mandviwala, Elisabet Sanchez and Stergios Boussios 2023. Clinical challenges in the management of malignant ovarian germ cell tumours. International Journal of Environmental Research and Public Health. 20 (12), p. 6089.
AuthorsIqra Saani, Nitish Raj, Raja Sood, Shahbaz Ansari, Haider Abbas Mandviwala, Elisabet Sanchez and Stergios Boussios
Abstract

Nonepithelial ovarian cancers (NEOC) are a group of rare malignancies, including germ cell tumours (GCT) and sex cord-stromal tumours (SCST), along with small-cell carcinomas and sarcomas. GCTs represent 2–5% of ovarian cancers, with a yearly incidence of 4:100,000, and they usually affect young women and adolescents. Precursory germ cells of the ovary form the basis of GCT. They are histologically classified into primitive GCT, teratomas, and monodermal and somatic-type tumours associated with dermoid cysts. A primitive GCT can be either a yolk sac tumour (YST), dysgerminoma, or mixed germ cell neoplasm. Teratomas are either mature (benign) or immature (malignant). Given that malignant GCTs occur rarely compared to epithelial ovarian tumours (EOC), greater focus is required in their diagnosis and treatment. In this article, we review the epidemiology, clinical manifestations, diagnosis, and molecular biology, along with the management and therapeutic challenges.

KeywordsOvarian germ cell tumours; Dysgerminomas; Yolk sac tumours; Treatment; Signalling pathways; Genome profiling
Year2023
JournalInternational Journal of Environmental Research and Public Health
Journal citation20 (12), p. 6089
PublisherMDPI
ISSN1661-7827
1660-4601
Official URLhttps://www.mdpi.com/1660-4601/20/12/6089
Publication dates
Online09 Jun 2023
Publication process dates
Accepted25 Apr 2023
Deposited14 Sep 2023
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https://repository.canterbury.ac.uk/item/95v92/clinical-challenges-in-the-management-of-malignant-ovarian-germ-cell-tumours

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