Precision oncology through next generation sequencing in hepatocellular carcinoma.

Journal article

Shinde, Sayali, Bigogno, Carola Maria, Simmons, Ana, Kathuria, Nikita, Ghose, Aruni, Apte, Vedika, Lapitan, Patricia, Makker, Shania, Caglayan, Aydin and Boussios, Stergios 2025. Precision oncology through next generation sequencing in hepatocellular carcinoma. Heliyon. 11 (3), p. e42054. https://doi.org/10.1016/j.heliyon.2025.e42054
AuthorsShinde, Sayali, Bigogno, Carola Maria, Simmons, Ana, Kathuria, Nikita, Ghose, Aruni, Apte, Vedika, Lapitan, Patricia, Makker, Shania, Caglayan, Aydin and Boussios, Stergios
AbstractHepatocellular carcinoma (HCC) is a primary liver cancer that originates from underlying inflammation, often associated with Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infections. Despite the availability of treatments, there are high rates of tumour relapse due to the development of drug resistance in infected cells. Next-Generation Sequencing (NGS) plays a crucial role in overcoming this issue by sequencing both viral and host genomes to identify mutations and genetic heterogeneity. The knowledge gained from sequencing is then utilised to develop countermeasures against these mutants through different combination therapies. Advances in NGS have led to sequencing with higher accuracy and throughput, thereby enabling personalized and effective treatments. The purpose of this article is to highlight how NGS has contributed to precision medicine in HCC and the possible integration of artificial intelligence (AI) to bolster the advancement. [Abstract copyright: Crown Copyright © 2025 Published by Elsevier Ltd.]
KeywordsVirus; Precision oncology; Hepatocellular carcinoma; Next generation sequencing; Artificial intelligence
Year2025
JournalHeliyon
Journal citation11 (3), p. e42054
ISSN2405-8440
Digital Object Identifier (DOI)https://doi.org/10.1016/j.heliyon.2025.e42054
Official URLhttps://www.sciencedirect.com/science/article/pii/S2405844025004347
Publication dates
Online17 Jan 2025
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Accepted15 Jan 2025
Deposited24 Feb 2025
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Open
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