Advances in adoptive T-cell therapy for metastatic melanoma

Journal article

Das, Aparimita, Ghose, Aruni, Naicker, Kevin, Sanchez, Elisabet, Chargari, Cyrus, Rassy, Elie and Boussios, S. 2023. Advances in adoptive T-cell therapy for metastatic melanoma. Current Research in Translational Medicine. 71 (3), p. 103404. https://doi.org/10.1016/j.retram.2023.103404
AuthorsDas, Aparimita, Ghose, Aruni, Naicker, Kevin, Sanchez, Elisabet, Chargari, Cyrus, Rassy, Elie and Boussios, S.
AbstractAdoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic melanoma (MM). Identifying tumour antigens (TAs) as potential targets, the ACT response is mediated by either Tumour Infiltrating Lymphocytes (TILs) or genetically modified T cells with specific receptors – T cell receptors (TCRs) or chimeric antigen receptors (CARs) or more prospectively, natural killer (NK) cells. Clinical trials involving ACT in MM from 2006 to present have shown promising results. Yet it is not without its drawbacks which include significant auto-immune toxicity and need for pre-conditioning lymphodepletion. Although immune-modulation is underway using various combination therapies in the hope of enhancing efficacy and reducing toxicity. Our review article explores the role of ACT in MM, including the various modalities – their safety, efficacy, risks and their development in the trial and the real world setting.
KeywordsAdoptive T cell therapy (ACT) ; Immunotherapy ; Oncology; Cancer treatment
Year2023
JournalCurrent Research in Translational Medicine
Journal citation71 (3), p. 103404
PublisherElsevier
ISSN24523186
Digital Object Identifier (DOI)https://doi.org/10.1016/j.retram.2023.103404
Official URLhttps://www.sciencedirect.com/science/article/abs/pii/S2452318623000284
Publication dates
Online19 Jul 2023
Publication process dates
Accepted06 Jul 2023
Deposited26 Jul 2023
Output statusPublished
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