Advances in adoptive T-cell therapy for metastatic melanoma

Journal article

Das, Aparimita, Ghose, Aruni, Naicker, Kevin, Sanchez, Elisabet, Chargari, Cyrus, Rassy, Elie and Boussios, S. 2023. Advances in adoptive T-cell therapy for metastatic melanoma. Current Research in Translational Medicine. 71 (3), p. 103404. https://doi.org/10.1016/j.retram.2023.103404
AuthorsDas, Aparimita, Ghose, Aruni, Naicker, Kevin, Sanchez, Elisabet, Chargari, Cyrus, Rassy, Elie and Boussios, S.
AbstractAdoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic melanoma (MM). Identifying tumour antigens (TAs) as potential targets, the ACT response is mediated by either Tumour Infiltrating Lymphocytes (TILs) or genetically modified T cells with specific receptors – T cell receptors (TCRs) or chimeric antigen receptors (CARs) or more prospectively, natural killer (NK) cells. Clinical trials involving ACT in MM from 2006 to present have shown promising results. Yet it is not without its drawbacks which include significant auto-immune toxicity and need for pre-conditioning lymphodepletion. Although immune-modulation is underway using various combination therapies in the hope of enhancing efficacy and reducing toxicity. Our review article explores the role of ACT in MM, including the various modalities – their safety, efficacy, risks and their development in the trial and the real world setting.
KeywordsAdoptive T cell therapy (ACT) ; Immunotherapy ; Oncology; Cancer treatment
Year2023
JournalCurrent Research in Translational Medicine
Journal citation71 (3), p. 103404
PublisherElsevier
ISSN24523186
Digital Object Identifier (DOI)https://doi.org/10.1016/j.retram.2023.103404
Official URLhttps://www.sciencedirect.com/science/article/abs/pii/S2452318623000284
Publication dates
Online19 Jul 2023
Publication process dates
Accepted06 Jul 2023
Deposited26 Jul 2023
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/9527w/advances-in-adoptive-t-cell-therapy-for-metastatic-melanoma

  • 79
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Disentangling the Gordian Knot of parasympathetic innervations in arthritic joint
Mathew, Sharon, Boussios, S. and Ovsepian, Saak V. 2025. Disentangling the Gordian Knot of parasympathetic innervations in arthritic joint. Neuroscience. 573, pp. 518-520. https://doi.org/10.1016/j.neuroscience.2025.03.061
Evaluating AI adoption in healthcare: Insights from the information governance professionals in the United Kingdom.
Olawade, David B, Weerasinghe, Kusal, Teke, J., Msiska, Maines, Boussios, S. and Hatzidimitriadou, E. 2025. Evaluating AI adoption in healthcare: Insights from the information governance professionals in the United Kingdom. International Journal of Medical Informatics. 199, p. 105909. https://doi.org/10.1016/j.ijmedinf.2025.105909
Integrating AI into cancer Iimmunotherapy-A narrative review of current applications and future directions
Olawade, D., Clement David-Olawade, A., Adereni, T., Egbon, E., Teke, J. and Boussios, S. 2025. Integrating AI into cancer Iimmunotherapy-A narrative review of current applications and future directions. Diseases. 13 (1), p. 24.
Spotlight on lung cancer disparities in India
Gunani, Manas, Winayak, Rahul, Agarwal, Anisha, Ghose, Aruni, Das, Rounak, Prabhash, Kumar, Noronha, Vanita, Banna, Giuseppe Luigi, Boussios, S. and Mitra, Swarupa 2025. Spotlight on lung cancer disparities in India. JCO Global Oncology.
Spinal MRI in patients with suspected metastatic spinal cord compression: a quality improvement audit in a district general hospital in Kent, UK
Rabbani, Rukhshana Dina, Hasan, Mahmudul Rahat, Akter, Sumaya, Chilakuluri, Premsai, Banerjee, Soirindhri, Ghose, Aruni, Sanchez, Elisabet, Ahmadu, Temitayo, Papadopoulos, Vasileios, Teke, Jennifer, Olawade, David, Ovsepian, Saak Victor and Boussios, Stergios 2025. Spinal MRI in patients with suspected metastatic spinal cord compression: a quality improvement audit in a district general hospital in Kent, UK. International Journal of Environmental Research and Public Health. 22 (3), p. 401.
Male breast cancer: A single institutional clinicopathological profiling
De Sarkar, Shubha, Banerjee, Soirindhri, Ismail, Ayden, Mavadia, Avenie, Choi, Sunyoung, Ghose, Aruni and Boussios, Stergios 2025. Male breast cancer: A single institutional clinicopathological profiling. Anticancer Research. 45 (3), pp. 1097-1104. https://doi.org/10.21873/anticanres.17497
Diagnosis and treatment of gestational non-epithelial ovarian cancer: A systematic review
Ahmadu, Temitayo, Olawade, David B, Teke, Jennifer, Bachour, Michel-Elie, Rabbani, Rukhshana Dina, Akter, Sumaya, Sanchez, Elisabet, Papadopoulos, Vasileios, Ovsepian, Saak V and Boussios, Stergios 2025. Diagnosis and treatment of gestational non-epithelial ovarian cancer: A systematic review. Anticancer Research. 45 (3), pp. 843-853. https://doi.org/10.21873/anticanres.17473
Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment.
Abooali, Maryam, Schlichtner, Stephanie, Lei, Xi, Aliu, Nijas, Ruggiero, Sabrina, Loges, Sonia, Ziegler, Martin, Hertel, Franziska, Volckmar, Anna-Lena, Stenzinger, Albrecht, Christopoulos, Petros, Thomas, Michael, Klenova, Elena, Meyer, N Helge, Boussios, Stergios, Heaton, Nigel, Zen, Yoh, Zamalloa, Ane, Chokshi, Shilpa, Urbani, Luca, Richard, Sophie, Kirubendran, Kavitha, Hussain, Rohanah, Siligardi, Giuliano, Cholewa, Dietmar, Berger, Steffen M, Yasinska, Inna M, Fasler-Kan, Elizaveta and Sumbayev, Vadim V 2025. Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment. Cancer Letters. 616, p. 217581. https://doi.org/10.1016/j.canlet.2025.217581
Precision oncology through next generation sequencing in hepatocellular carcinoma
Shinde, Sayali, Bigogno, Carola Maria, Simmons, Ana, Kathuria, Nikita, Ghose, Aruni, Apte, Vedika, Lapitan, Patricia, Makker, Shania, Caglayan, Aydin and Boussios, Stergios 2025. Precision oncology through next generation sequencing in hepatocellular carcinoma. Heliyon. 11 (3), p. e42054. https://doi.org/10.1016/j.heliyon.2025.e42054
The impact of AI-driven remote patient monitoring on cancer care: A systematic review
Aziz, Fayha, Bianchini, Diletta, Olawade, David B. and Boussios, Stergios 2025. The impact of AI-driven remote patient monitoring on cancer care: A systematic review. Anticancer Research. 45 (2), pp. 407-418. https://doi.org/10.21873/anticanres.17430
Exosomal liquid biopsy in prostate cancer: A systematic review of biomarkers for diagnosis, prognosis, and treatment response
Hamid, Y., Rabbani, R., Afsara, R., Nowrin, Samarea, Ghose, A., Papadopoulos, Vasileios, Sirlantzis, K., Ovsepian, S. and Boussios, S. 2025. Exosomal liquid biopsy in prostate cancer: A systematic review of biomarkers for diagnosis, prognosis, and treatment response. International Journal of Molecular Sciences. 26 (2), p. 802. https://doi.org/10.3390/ijms26020802
Molecular biomarkers of glial activation and injury in epilepsy
Kalsariya, Reema A, Kavila, Dave, Shorter, Susan, Negi, Deepika, Goodall, Iain C A, Boussios, Stergios and Ovsepian, Saak V 2025. Molecular biomarkers of glial activation and injury in epilepsy. Drug Discovery Today. 30 (2), p. 104289. https://doi.org/10.1016/j.drudis.2025.104289
lncRNA biomarkers of glioblastoma multiforme
Pokorná, Markéta, Černá, M., Boussios, S., Ovsepian, S. and O’Leary, V. 2024. lncRNA biomarkers of glioblastoma multiforme. Biomedicines. 12 (5), p. 932.
Construction of a prognostic survival model with tumor immune-related genes for breast cancer
Guo, Shuai, Guo, Liang, Li, Jiangyun, Li, Jianguo, Zhang, Qiqi, Zhang, Jing, Boussios, Stergios and Toi, Masakazu 2024. Construction of a prognostic survival model with tumor immune-related genes for breast cancer. Translational Cancer Research. 13 (12), pp. 6919-6935. https://doi.org/10.21037/tcr-24-2137
AI-guided cancer therapy for patients with coexisting migraines
Olawade, D., Teke, J., Adeleye, K., Egbon, E., Weerasinghe, K., Ovespian, S. and Boussios, S. 2024. AI-guided cancer therapy for patients with coexisting migraines. Cancers. 16 (21), p. 3690. https://doi.org/10.3390/cancers16213690
An orthogonal approach for analysis of underivatized steroid hormones using ultrahigh performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS).
Devo, Perry, Cretu, Victoria, Radhakrishnan, Harsha, Hamilton-Pink, Darren, Boussios, Stergios and Ovsepian, S. 2024. An orthogonal approach for analysis of underivatized steroid hormones using ultrahigh performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS). Journal of Neural Transmission. https://doi.org/10.1007/s00702-024-02862-3
Bilateral dermoid ovarian cysts in a young woman - A case report and literature review
Pinnamaneni, Sravya, Sayani, Sunayana, Chilakuluri, Premsai and Boussios, Stergios 2024. Bilateral dermoid ovarian cysts in a young woman - A case report and literature review. Cancer diagnosis & prognosis. 4 (6), pp. 819-824. https://doi.org/10.21873/cdp.10402
Early adoption of innovation in HPV prevention strategies: closing the gap in cervical cancer.
Mahajan, Ishika, Kadam, Amogh, McCann, Lucy, Ghose, Aruni, Wakeham, Katie, Dhillon, Navjot Singh, Stanway, Susannah, Boussios, Stergios, Banerjee, Soirindhri, Priyadarshini, Ashwini, Sirohi, Bhawna, Torode, Julie S and Mitra, Swarupa 2024. Early adoption of innovation in HPV prevention strategies: closing the gap in cervical cancer. Ecancermedicalscience. 18, p. 1762. https://doi.org/10.3332/ecancer.2024.1762
Applying whole-genome and whole-exome sequencing in breast cancer: a review of the landscape
Hetvi Ganatra, Joecelyn Kirani Tan, Ana Simmons, Carola Maria Bigogno, Vatsala Khurana, Aruni Ghose, Adheesh Ghosh, Ishika Mahajan, Boussios, S., Akash Maniam and Olubukola Ayodele 2024. Applying whole-genome and whole-exome sequencing in breast cancer: a review of the landscape. Breast Cancer.
Paediatric anatomical models in radiotherapy applications
Apte, V, Ghose, A, Linares, C A, Adeleke, S, Papadopoulos, V, Rassy, E and Boussios, S 2024. Paediatric anatomical models in radiotherapy applications. Clinical Oncology (Royal College of Radiologists (Great Britain)). https://doi.org/10.1016/j.clon.2024.06.051
Large language models in oncology: Revolution or cause for concern?
Caglayan, Aydin, Slusarczyk, Wojciech, Rabbani, Rukhshana Dina, Ghose, Aruni, Papadopoulos, Vasileios and Boussios, Stergios 2024. Large language models in oncology: Revolution or cause for concern? Current Oncology. 31 (4). https://doi.org/10.3390/curroncol31040137
Antibody drug conjugates in urological cancers: A review of the current landscape
Ghose, Aruni, Lapitan, Patricia, Apte, Vedika, Ghosh, Adheesh, Kandala, Abhinav, Basu, Sreejana, Parkes, Jo, Shinde, Sayali D, Boussios, Stergios, Sharma, Anand, Das, Prantik, Vasdev, Nikhil, Rebuzzi, Sara E, Ürün, Yüksel, Kanesvaran, Ravindran, Maniam, Akash and Banna, Giuseppe L 2024. Antibody drug conjugates in urological cancers: A review of the current landscape. Current Oncology Reports. https://doi.org/10.1007/s11912-024-01524-7
The application of radiomics and AI to molecular imaging for prostate cancer
Tapper, William, Carneiro, G., Mikropoulos, C., Thomas, Spencer A., Evans, P. and Boussios, S. 2024. The application of radiomics and AI to molecular imaging for prostate cancer. Journal of Personalized Medicine. 14 (3), p. 287. https://doi.org/10.3390/jpm14030287
Immunotherapy combined with standard therapies in head and neck squamous cell carcinoma - a meta-analysis
Eden, Daisy, Ghose, Aruni, Moschetta, Michele, Pérez-Fidalgo, José Alejandro, Rassy, Elie and Boussios, Stergios 2024. Immunotherapy combined with standard therapies in head and neck squamous cell carcinoma - a meta-analysis. Anticancer Research. 44 (3), pp. 861-878. https://doi.org/10.21873/anticanres.16880
Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4
Ghose, A., McCann, Lucy, Makker, S., Mukherjee, Uma, Gullapalli, Sri Vidya Niharika, Erekkath, Jayaraj, Shih, Stephanie, Mahajan, Ishika, Sanchez, Elisabet, Uccello, Mario, Moschetta, Michele, Adeleke, S. and Boussios, Stergios 2024. Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4. Therapeutic Advances in Medical Oncology. 16. https://doi.org/10.1177/17588359241233225
A rare case of metaplastic breast carcinoma from India: Towards precision oncology (Case Report)
Soirindhri Banerjee, Ishika Mahajan, Aruni Ghose, Stergios Boussios and Shivam Chakraborty 2024. A rare case of metaplastic breast carcinoma from India: Towards precision oncology (Case Report). Cancer Reports. https://doi.org/10.1002/cnr2.1997
Stage 3 N2 lung cancer: A multidisciplinary therapeutic conundrum
Lily Carter, Vedika Apte, Arushi Shukla, Aruni Ghose, Raj Mamidi, Alexandra Petohazi, Shania Makker, Soirindhri Banerjee, Stergios Boussios and Giuseppe L. Banna 2024. Stage 3 N2 lung cancer: A multidisciplinary therapeutic conundrum. Current Oncology Reports. 26, pp. 65-79.
Frontiers of molecular biology of cancer
Boussios, S., Sanchez, E. and Sheriff, M. 2023. Frontiers of molecular biology of cancer. International Journal of Molecular Sciences.
Frontiers of ovarian carcinosarcoma
Ismail, A., Choi, S. and Boussios, S. 2023. Frontiers of ovarian carcinosarcoma. Current Treatment Options in Oncology. https://doi.org/10.1007/s11864-023-01138-4
Astragaloside IV enhances the sensitivity of breast cancer stem cells to paclitaxel by inhibiting stemness
Ping Huang, Huachao Li, Liping Ren, Haimei Xie, Liushan Chen, Yuqi Liang, Yuyu Hu, Heloisa Sobreiro Selistre-de-Araujo, Stergios Boussios, Sachin R. Jhawar, Rutao Cui, Qian Zuo and Qianjun Chen 2023. Astragaloside IV enhances the sensitivity of breast cancer stem cells to paclitaxel by inhibiting stemness. Translational Cancer Research. 12 (12).
Hallmarks of the tumour microenvironment of gliomas and its interaction with emerging immunotherapy modalities
Christian A. Linares, Anjana Varghese, Aruni Ghose, Sayali D. Shinde, Sola Adeleke, Elisabet Sanchez, Matin Sheriff, Cyrus Chargari, Elie Rassy and Stergios Boussios 2023. Hallmarks of the tumour microenvironment of gliomas and its interaction with emerging immunotherapy modalities. International Journal of Molecular Sciences. 24 (17), p. 13215. https://doi.org/10.3390/ijms241713215
Prognostic factors in patients with metastatic spinal cord compression secondary to lung cancer—A retrospective UK single-centre study
Anna Vassiliou, Temidayo Osunronbi, Synthia Enyioma, Gerardo Rago, Afroditi Karathanasi, Aruni Ghose, Matin Sheriff, Christos Mikropoulos, Elisabet Sanchez, Michele Moschetta, Cyrus Chargari, Elie Rassy and Stergios Boussios 2023. Prognostic factors in patients with metastatic spinal cord compression secondary to lung cancer—A retrospective UK single-centre study. Cancers. 15 (18), p. 4432. https://doi.org/10.3390/cancers15184432
Exosomes in the diagnosis and treatment of renal cell cancer
Boussios, S., Devo, P., Goodall, Iain C A, Sirlantzis, Konstantinos, Ghose, A., Shinde, Sayali D, Papadopoulos, Vasileios, Sanchez, Elisabet, Rassy, E. and Ovsepian, Saak V 2023. Exosomes in the diagnosis and treatment of renal cell cancer. International Journal of Molecular Sciences. 24 (18), p. 14356. https://doi.org/10.3390/ijms241814356
Immunotherapy for advanced urothelial carcinoma (UC): rational and current evidence
Mario Uccello, Sola Adeleke, Michele Moschetta, Aruni Ghose and Stergios Boussios 2023. Immunotherapy for advanced urothelial carcinoma (UC): rational and current evidence. Annals of Palliative Medicine. https://doi.org/10.21037/apm-22-1350
Clinical challenges in the management of malignant ovarian germ cell tumours
Iqra Saani, Nitish Raj, Raja Sood, Shahbaz Ansari, Haider Abbas Mandviwala, Elisabet Sanchez and Stergios Boussios 2023. Clinical challenges in the management of malignant ovarian germ cell tumours. International Journal of Environmental Research and Public Health. 20 (12), p. 6089.
Impact of COVID-19 on cancer services and patients' outcomes: a retrospective single-center study
Baijaeek Sain, Arnab Gupta, Aruni Ghose, Sudip Halder, Samir Bhattacharya, Radha Raman Mondal, Subhamoy Paul, Chandrakanth Are and Stergios Boussios 2023. Impact of COVID-19 on cancer services and patients' outcomes: a retrospective single-center study. Annals of Translational Medicine. 11 (9). https://doi.org/10.21037/atm-22-5876
Prostate cancer - what about oligometastatic disease and stereotactic ablative radiotherapy? - a narrative review
Boussios, S., Saxby, H. and Mikropoulos, C. 2023. Prostate cancer - what about oligometastatic disease and stereotactic ablative radiotherapy? - a narrative review. Annals of Palliative Medicine. 12 (3). https://doi.org/10.21037/apm-22-828
HPV and cervical cancer: A review of epidemiology and screening uptake in the UK
Sunyoung Choi, Ayden Ismail, George Pappas-Gogos and Stergios Boussios 2023. HPV and cervical cancer: A review of epidemiology and screening uptake in the UK. Pathogens (Basel, Switzerland). 12 (2). https://doi.org/10.3390/pathogens12020298
Constrictive pericarditis–a cloak camouflaging lymphoma
Delanthabettu Venugopala, Nikhil Victor Dsouza, Vishak Acharya, Maneesh Rai, Chaithra Gowthuvalli Venkataramana and Stergios Boussios 2022. Constrictive pericarditis–a cloak camouflaging lymphoma. Hematology Reports. 15 (1), pp. 166-171. https://doi.org/10.3390/hematolrep15010017