Advances in adoptive T-cell therapy for metastatic melanoma
Journal article
Das, Aparimita, Ghose, Aruni, Naicker, Kevin, Sanchez, Elisabet, Chargari, Cyrus, Rassy, Elie and Boussios, S. 2023. Advances in adoptive T-cell therapy for metastatic melanoma. Current Research in Translational Medicine. 71 (3), p. 103404. https://doi.org/10.1016/j.retram.2023.103404
| Authors | Das, Aparimita, Ghose, Aruni, Naicker, Kevin, Sanchez, Elisabet, Chargari, Cyrus, Rassy, Elie and Boussios, S. |
|---|---|
| Abstract | Adoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic melanoma (MM). Identifying tumour antigens (TAs) as potential targets, the ACT response is mediated by either Tumour Infiltrating Lymphocytes (TILs) or genetically modified T cells with specific receptors – T cell receptors (TCRs) or chimeric antigen receptors (CARs) or more prospectively, natural killer (NK) cells. Clinical trials involving ACT in MM from 2006 to present have shown promising results. Yet it is not without its drawbacks which include significant auto-immune toxicity and need for pre-conditioning lymphodepletion. Although immune-modulation is underway using various combination therapies in the hope of enhancing efficacy and reducing toxicity. Our review article explores the role of ACT in MM, including the various modalities – their safety, efficacy, risks and their development in the trial and the real world setting. |
| Keywords | Adoptive T cell therapy (ACT) ; Immunotherapy ; Oncology; Cancer treatment |
| Year | 2023 |
| Journal | Current Research in Translational Medicine |
| Journal citation | 71 (3), p. 103404 |
| Publisher | Elsevier |
| ISSN | 24523186 |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/j.retram.2023.103404 |
| Official URL | https://www.sciencedirect.com/science/article/abs/pii/S2452318623000284 |
| Publication dates | |
| Online | 19 Jul 2023 |
| Publication process dates | |
| Accepted | 06 Jul 2023 |
| Deposited | 26 Jul 2023 |
| Output status | Published |
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https://repository.canterbury.ac.uk/item/9527w/advances-in-adoptive-t-cell-therapy-for-metastatic-melanoma
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