Disentangling the Gordian Knot of parasympathetic innervations in arthritic joint

Journal article

Mathew, Sharon, Boussios, S. and Ovsepian, Saak V. 2025. Disentangling the Gordian Knot of parasympathetic innervations in arthritic joint. Neuroscience. 573, pp. 518-520. https://doi.org/10.1016/j.neuroscience.2025.03.061
AuthorsMathew, Sharon, Boussios, S. and Ovsepian, Saak V.
AbstractHealthy synovial joints receive innervations exclusively from sensory and sympathetic axons. In arthritis, however, they acquire cholinergic innervations with parasympathetic effects. The origin of cholinergic fibres in inflamed joints remains elusive. Based on clinical and preclinical evidence, we propose two models explaining their rise: (1) through sprouting and invasion of cholinergic sympathetic or parasympathetic axons from the periosteum of juxta-articular bones and (2) via phenotypic switch of intrinsic sympathetic (norepinephrinergic) fibres of synovial joints to cholinergic. The widely acknowledged anti-inflammatory and immunosuppressants effects of parasympathetic drive suggests a protective role of the newly aquired cholinergic innervations in arthritic joints. [Abstract copyright: Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.]
KeywordsNeural remodelling; Cholinergic profiles; Synovial joints; Arthritis; Parasympathetic system
Year2025
JournalNeuroscience
Journal citation573, pp. 518-520
PublisherElsevier
ISSN1873-7544
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neuroscience.2025.03.061
Official URLhttps://www.sciencedirect.com/science/article/pii/S0306452225002635
Publication dates
Online01 Apr 2025
Publication process dates
Accepted25 Mar 2025
Deposited23 Apr 2025
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Open
Output statusPublished
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