Molecular biomarkers of glial activation and injury in epilepsy

Journal article

Kalsariya, Reema A, Kavila, Dave, Shorter, Susan, Negi, Deepika, Goodall, Iain C A, Boussios, Stergios and Ovsepian, Saak V 2025. Molecular biomarkers of glial activation and injury in epilepsy. Drug Discovery Today. 30 (2), p. 104289. https://doi.org/10.1016/j.drudis.2025.104289
AuthorsKalsariya, Reema A, Kavila, Dave, Shorter, Susan, Negi, Deepika, Goodall, Iain C A, Boussios, Stergios and Ovsepian, Saak V
AbstractIncreasing evidence from fluid biopsies suggests activation and injury of glial cells in epilepsy. The prevalence of clinical and subclinical seizures in neurodegenerative conditions such as Alzheimer's disease, frontotemporal dementia, and others merits review and comparison of the effects of seizures on glial markers in epilepsy and neurodegenerative diseases with concomitant seizures. Herein, we revisit preclinical and clinical reports of alterations in glial proteins in cerebrospinal fluid and blood associated with various types of epilepsy. We consider shared and distinct characteristics of changes in different age groups and sexes, in humans and animal models of epilepsy, and compare them with those reported in biofluids in neurodegenerative diseases. Our analysis indicates a significant overlap of glial response in these prevalent neurological conditions. [Abstract copyright: Copyright © 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved.]
KeywordsGFAP; Neurodegeneration; S100β; Fluid biopsy; Neuroinflammation; IL-6; TNF-α; Status epilepticus; HMGB1; IL-1β
Year2025
JournalDrug Discovery Today
Journal citation30 (2), p. 104289
PublisherElsevier
ISSN1878-5832
Digital Object Identifier (DOI)https://doi.org/10.1016/j.drudis.2025.104289
Official URLhttps://www.sciencedirect.com/science/article/pii/S1359644625000029
Publication dates
Online10 Jan 2025
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Accepted06 Jan 2025
Deposited27 Jan 2025
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Open
Output statusPublished
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