HPV and cervical cancer: A review of epidemiology and screening uptake in the UK

Journal article


Sunyoung Choi, Ayden Ismail, George Pappas-Gogos and Stergios Boussios 2023. HPV and cervical cancer: A review of epidemiology and screening uptake in the UK. Pathogens (Basel, Switzerland). 12 (2). https://doi.org/10.3390/pathogens12020298
AuthorsSunyoung Choi, Ayden Ismail, George Pappas-Gogos and Stergios Boussios
Abstract

Cervical cancer is the fourth most common malignancy in females worldwide, and a leading cause of death in the United Kingdom (UK). The human papillomavirus (HPV) is the strongest risk factor for developing cervical intraepithelial neoplasia and cancer. Across the UK, the national HPV immunisation programme, introduced in 2008, has been successful in protecting against HPV-related infections. Furthermore, the National Health Service (NHS) implemented the cytology-based cervical cancer screening service to all females aged 25 to 64, which has observed a decline in cervical cancer incidence. In the UK, there has been an overall decline in age-appropriate coverage since April 2010. In 2019, the COVID-19 pandemic disrupted NHS cancer screening and immunisation programmes, leading to a 6.8% decreased uptake of cervical cancer screening from the previous year. Engagement with screening has also been associated with social deprivation. In England, incidence rates of cervical cancer were reported to be 65% higher in the most deprived areas compared to the least, with lifestyle factors such as cigarette consumption contributing to 21% of cervical cancer cases. In this article, we provide an update on the epidemiology of cervical cancer, and HPV pathogenesis and transmission, along with the current prevention programmes within the NHS.

KeywordsHPV; Cervical cancer; Epidemiology; Risk factors; Cervical cancer screening; HPV vaccination
Year2023
JournalPathogens (Basel, Switzerland)
Journal citation12 (2)
PublisherMDPI
ISSN2076-0817
Digital Object Identifier (DOI)https://doi.org/10.3390/pathogens12020298
Official URLhttps://www.mdpi.com/2076-0817/12/2/298/htm
Publication dates
Online11 Feb 2023
Publication process dates
Accepted09 Feb 2023
Deposited29 Jun 2023
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Output statusPublished
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https://repository.canterbury.ac.uk/item/94z13/hpv-and-cervical-cancer-a-review-of-epidemiology-and-screening-uptake-in-the-uk

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