Hallmarks of the tumour microenvironment of gliomas and its interaction with emerging immunotherapy modalities

Journal article


Christian A. Linares, Anjana Varghese, Aruni Ghose, Sayali D. Shinde, Sola Adeleke, Elisabet Sanchez, Matin Sheriff, Cyrus Chargari, Elie Rassy and Stergios Boussios 2023. Hallmarks of the tumour microenvironment of gliomas and its interaction with emerging immunotherapy modalities. International Journal of Molecular Sciences. 24 (17), p. 13215. https://doi.org/10.3390/ijms241713215
AuthorsChristian A. Linares, Anjana Varghese, Aruni Ghose, Sayali D. Shinde, Sola Adeleke, Elisabet Sanchez, Matin Sheriff, Cyrus Chargari, Elie Rassy and Stergios Boussios
Abstract

Gliomas are aggressive, primary central nervous system tumours arising from glial cells. Glioblastomas are the most malignant. They are known for their poor prognosis or median overall survival. The current standard of care is overwhelmed by the heterogeneous, immunosuppressive tumour microenvironment promoting immune evasion and tumour proliferation. The advent of immunotherapy with its various modalities—immune checkpoint inhibitors, cancer vaccines, oncolytic viruses and chimeric antigen receptor T cells and NK cells—has shown promise. Clinical trials incorporating combination immunotherapies have overcome the microenvironment resistance and yielded promising survival and prognostic benefits. Rolling these new therapies out in the real-world scenario in a low-cost, high-throughput manner is the unmet need of the hour. These will have practice-changing implications to the glioma treatment landscape. Here, we review the immunobiological hallmarks of the TME of gliomas, how the TME evades immunotherapies and the work that is being conducted to overcome this interplay.

KeywordsGliomas; Tumour microenvironment; Immunotherapy; Immune checkpoint inhibitors; Therapeutic cancer vaccines; Oncolytic virotherapy; Chimeric antigen receptors
Year2023
JournalInternational Journal of Molecular Sciences
Journal citation24 (17), p. 13215
PublisherMDPI
ISSN1661-6596
1422-0067
Digital Object Identifier (DOI)https://doi.org/10.3390/ijms241713215
Official URLhttps://www.mdpi.com/1422-0067/24/17/13215
Publication dates
Online25 Aug 2023
Publication process dates
Accepted21 Aug 2023
Deposited07 Dec 2023
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Open
Output statusPublished
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https://repository.canterbury.ac.uk/item/96891/hallmarks-of-the-tumour-microenvironment-of-gliomas-and-its-interaction-with-emerging-immunotherapy-modalities

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