Prediction of small-for-gestational-age neonates at 35-37 weeks' gestation: contribution of maternal factors and growth velocity between 32 and 36 weeks
Ciobanu, A., Anthoulakis, C., Syngelaki, A., Akolekar, R. and Nicolaides, K.H. 2019. Prediction of small-for-gestational-age neonates at 35-37 weeks' gestation: contribution of maternal factors and growth velocity between 32 and 36 weeks. Ultrasound in Obstetrics and Gynecology. 53 (5), pp. 630-637.
|Authors||Ciobanu, A., Anthoulakis, C., Syngelaki, A., Akolekar, R. and Nicolaides, K.H.|
Objective: To assess the additive value of fetal growth velocity between 32 and 36 weeks’ gestation on the performance of ultrasonographic estimated fetal weight (EFW) at 35+0 - 36+6 weeks’ gestation for prediction of small for gestational age (SGA) neonates and adverse perinatal outcome.
Methods: This was a prospective study of 14,497 singleton pregnancies that had undergone routine ultrasound examination at 28+0 - 34+6 and at 35+0 - 36+6 weeks’ gestation. Multivariable logistic regression analysis was used to determine whether addition of growth velocity, defined by a difference in EFW and abdominal circumference (AC) Z-scores between the early and late third trimester scans divided by the time interval between them, improved the performance of EFW at 35+0 - 36+6 weeks in the prediction of first, delivery of SGA neonates with birthweight <10th and <3rd percentiles within two weeks and at any stage after assessment and second, composite of adverse perinatal outcome defined as stillbirth, neonatal death or admission to the neonatal unit for ≥48 hours.
Results Multivariable logistic regression analysis demonstrated that significant contributors to prediction of SGA neonates were EFW Z-score at 35+0 - 36+6 weeks’ gestation, fetal growth velocity by either AC or EFW Z-scores and maternal risk factors. The area under the receiver operating characteristic curves (AUROC) and detection rate (DR) with 95% confidence interval, at 10% screen positive rate, for prediction of SGA neonates <10th percentile born within two weeks of assessment achieved by EFW Z-score at 35+0 - 36+6 weeks (AUROC 0.938, 0.928 - 0.947; DR 80.7, 77.6 - 83.9) were not significantly improved by addition of EFW growth velocity and maternal risk factors (AUROC 0.941, 0.932 - 0.950; p=0.061; DR 82.5, 79.4 - 85.3). Similar results were obtained when growth velocity was defined by AC rather than EFW growth velocity. Similarly, there was no significant improvement in AUROC and DR, at 10% screen positive rate, for prediction of SGA neonates <10th percentile born at any stage after assessment or SGA neonates <3rd percentile born within two weeks or at any stage after assessment achieved by EFW Z-score at 35+0 - 36+6 weeks by addition of maternal factors and either EFW growth velocity of AC growth velocity. Multivariable logistic regression analysis demonstrated that the only significant contributor to adverse perinatal outcome was maternal risk factors. Multivariable logistic regression analysis in the group with EFW <10th percentile demonstrated that significant contribution to prediction of birth of neonates with birthweight <10th and <3rd percentiles and adverse perinatal outcome was provided by EFW Z-score at 35+0 - 36+6 weeks, but not by AC growth velocity <1st decile.
Conclusion: The predictive performance of EFW at 35+0 - 36+6 weeks’ gestation for birth of SGA neonates and adverse perinatal outcome is not improved by addition of estimated growth velocity between 32 and 36 weeks’ gestation.
|Keywords||Third trimester screening; Small for gestational age; Growth velocity; Estimated fetal weight; Growth charts.|
|Journal||Ultrasound in Obstetrics and Gynecology|
|Journal citation||53 (5), pp. 630-637|
|Publisher||John Wiley & Sons Ltd|
|Digital Object Identifier (DOI)||doi:10.1002/uog.20267|
|Online||26 Mar 2019|
|Publication process dates|
|Accepted||14 Mar 2019|
|Deposited||15 Jun 2020|
|Accepted author manuscript|
1. Lindhard A, Nielsen PV, Mouritsen LA, Zachariassen A, Sørensen HU, Rosenø H.
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