Prediction of stillbirth from maternal factors, fetal biometry and uterine artery Doppler at 19-24 weeks
Akolekar, R., Tokunaka, M., Ortega, N., Syngelaki, A. and Nicolaides, K. H. 2016. Prediction of stillbirth from maternal factors, fetal biometry and uterine artery Doppler at 19-24 weeks. Ultrasound in Obstetrics and Gynecology. 48 (5), pp. 624-630. https://doi.org/10.1002/uog.17295
|Authors||Akolekar, R., Tokunaka, M., Ortega, N., Syngelaki, A. and Nicolaides, K. H.|
Objectives: To evaluate the performance of screening for all stillbirths and those due to impaired placentation and unexplained or other causes by a combination of maternal factors, fetal biometry and uterine artery pulsatility index (UT-PI) at 19-24 weeks’ gestation and compare this performance to that of screening by UT-PI alone.
Methods: This was a prospective screening study of 70,003 singleton pregnancies including 69,735 live births and 268 (0.38%) antepartum stillbirths; 159 (59%) were secondary to impaired placentation and 109 (41%) were due to other or unexplained causes. Multivariate logistic regression analysis was used to develop a model for prediction of stillbirth based on a combination of maternal factors, fetal biometry and UT-PI.
Conclusions: Second-trimester screening by a combination of UT-PI with maternal factors and fetal biometry can predict a high proportion of stillbirths and in particular those due to impaired placentation.
|Keywords||Stillbirth; Pyramid of pregnancy care; Uterine artery Doppler; Fetal biometry; Impaired placentation|
|Journal||Ultrasound in Obstetrics and Gynecology|
|Journal citation||48 (5), pp. 624-630|
|Digital Object Identifier (DOI)||https://doi.org/10.1002/uog.17295|
|Funder||Fetal Medicine Foundation|
|Online||09 Nov 2016|
|Publication process dates|
|Accepted||31 Aug 2016|
|Deposited||07 May 2020|
|Accepted author manuscript|
Fetal Medicine Foundation Grant Number: 1037116
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