Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation
Journal article
O'Gorman, N., Wright, D., Poon, L.C., Rolnik, D.L., Syngelaki, A., Wright, A., Akolekar, R., Cicero, S., Janga, D., Jani, J., Molina, F.S., de Paco Matallana, C., Papantoniou, N., Persico, N., Plasencia, W., Singh, M. and Nicolaides, K.H. 2017. Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation. Ultrasound in Obstetrics and Gynecology. 49 (6), pp. 751-755. https://doi.org/10.1002/uog.17399
Authors | O'Gorman, N., Wright, D., Poon, L.C., Rolnik, D.L., Syngelaki, A., Wright, A., Akolekar, R., Cicero, S., Janga, D., Jani, J., Molina, F.S., de Paco Matallana, C., Papantoniou, N., Persico, N., Plasencia, W., Singh, M. and Nicolaides, K.H. |
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Abstract | Objective: To examine the diagnostic accuracy of a previously developed model for prediction of preeclampsia (PE) by a combination of maternal factors and biomarkers at 11-13 weeks’ gestation. Methods: This was a prospective first-trimester multicenter study of screening for PE in 8,775 singleton pregnancies. A previously published algorithm was used for the calculation Results: In the study population there were 239 (2.7%) cases that developed PE, including 17 (0.2%), 59 (0.7%) and 180 (2.0%) at <32, <37 and >37 weeks, respectively. In combined screening by maternal factors, mean arterial pressure, uterine artery pulsatility index and serum placental growth factor the DR was 100% (95% CI 80-100) for PE at <32 weeks, 75% (95% CI 62-85) for PE at <37 weeks and 43% (95% CI 35-50) for PE at >37 weeks, at 10% FPR. These DRs were similar to the estimated rates in the dataset used for development of Conclusion: Combination of maternal factors and biomarkers provides effective firsttrimester screening for preterm-PE. |
Keywords | First-trimester screening; Preeclampsia; Pyramid of pregnancy care; Survival model; Bayes theorem; Uterine artery Doppler; Mean arterial pressure; Pregnancy associated plasma protein-A; Placental growth factor |
Year | 2017 |
Journal | Ultrasound in Obstetrics and Gynecology |
Journal citation | 49 (6), pp. 751-755 |
Publisher | Wiley |
ISSN | 1469-0705 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/uog.17399 |
Official URL | http://doi.org/10.1002/uog.17399 |
Related URL | https://pubmed.ncbi.nlm.nih.gov/28067011/ |
Publication dates | |
Online | 09 Jan 2017 |
Publication process dates | |
Accepted | 03 Jan 2017 |
Deposited | 10 Jun 2020 |
Accepted author manuscript | |
Output status | Published |
References | 1. O’Gorman N, Wright D, Syngelaki A, Akolekar R, Wright A, Poon LC, Nicolaides |
https://repository.canterbury.ac.uk/item/8vq26/accuracy-of-competing-risks-model-in-screening-for-pre-eclampsia-by-maternal-factors-and-biomarkers-at-11-13-weeks-gestation
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