Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin

Journal article

Balani, J., Hyer, S., Syngelaki, A., Akolekar, R., Nicolaides, K. H., Johnson, A. and Shehata, H. 2017. Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin. Obstetric Medicine. 10, pp. 170-173. https://doi.org/10.1177/1753495X17725465
AuthorsBalani, J., Hyer, S., Syngelaki, A., Akolekar, R., Nicolaides, K. H., Johnson, A. and Shehata, H.
Abstract

Objectives: To examine whether the reduced incidence of preeclampsia in non-diabetic obese pregnant women treated with metformin is mediated by changes in insulin resistance.

Methods: This was a secondary analysis of obese pregnant women in a randomised trial (MOP trial). Fasting plasma glucose and insulin were measured in 384 of the 400 women who participated in the MOP trial. Homeostasis model assessment of insulin resistance (HOMA-IR) was compared in the metformin and placebo groups and in those that developed preeclampsia versus those that did not develop preeclampsia.

Results: At 28 weeks, median HOMA-IR was significantly lower in the metformin group. Logistic regression analysis demonstrated that there was a significant contribution in the prediction of preeclampsia from maternal history of chronic hypertension and gestational weight gain, but not HOMA-IR
either at randomisation (p¼0.514) or at 28 weeks (p¼0.643).

Conclusions: Reduced incidence of preeclampsia in non-diabetic obese pregnant women treated with metformin is unlikely to be due to changes in insulin resistance.

KeywordsMetformin; Preeclampsia; Insulin resistance; Obesity; Pregnancy
Year2017
JournalObstetric Medicine
Journal citation10, pp. 170-173
PublisherSAGE Journals
ISSN1753-495X
Digital Object Identifier (DOI)https://doi.org/10.1177/1753495X17725465
Official URLhttp://doi.org/10.1177/1753495X17725465
Publication dates
Online16 Oct 2017
Print01 Dec 2017
Publication process dates
Accepted05 Jul 2017
Deposited28 May 2020
Output statusPublished
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