Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin
Journal article
Balani, J., Hyer, S., Syngelaki, A., Akolekar, R., Nicolaides, K. H., Johnson, A. and Shehata, H. 2017. Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin. Obstetric Medicine. 10, pp. 170-173. https://doi.org/10.1177/1753495X17725465
Authors | Balani, J., Hyer, S., Syngelaki, A., Akolekar, R., Nicolaides, K. H., Johnson, A. and Shehata, H. |
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Abstract | Objectives: To examine whether the reduced incidence of preeclampsia in non-diabetic obese pregnant women treated with metformin is mediated by changes in insulin resistance. Methods: This was a secondary analysis of obese pregnant women in a randomised trial (MOP trial). Fasting plasma glucose and insulin were measured in 384 of the 400 women who participated in the MOP trial. Homeostasis model assessment of insulin resistance (HOMA-IR) was compared in the metformin and placebo groups and in those that developed preeclampsia versus those that did not develop preeclampsia. Results: At 28 weeks, median HOMA-IR was significantly lower in the metformin group. Logistic regression analysis demonstrated that there was a significant contribution in the prediction of preeclampsia from maternal history of chronic hypertension and gestational weight gain, but not HOMA-IR Conclusions: Reduced incidence of preeclampsia in non-diabetic obese pregnant women treated with metformin is unlikely to be due to changes in insulin resistance. |
Keywords | Metformin; Preeclampsia; Insulin resistance; Obesity; Pregnancy |
Year | 2017 |
Journal | Obstetric Medicine |
Journal citation | 10, pp. 170-173 |
Publisher | SAGE Journals |
ISSN | 1753-495X |
Digital Object Identifier (DOI) | https://doi.org/10.1177/1753495X17725465 |
Official URL | http://doi.org/10.1177/1753495X17725465 |
Publication dates | |
Online | 16 Oct 2017 |
01 Dec 2017 | |
Publication process dates | |
Accepted | 05 Jul 2017 |
Deposited | 28 May 2020 |
Output status | Published |
https://repository.canterbury.ac.uk/item/8v96w/association-between-insulin-resistance-and-preeclampsia-in-obese-non-diabetic-women-receiving-metformin
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