Maternal race and stillbirth: Cohort study and systematic review with meta-analysis.

Journal article


Arechvo, Anastasija, Nikolaidi, Despoina A, Gil, M., Rolle, V., Syngelaki, A., Akolekar, Ranjit and Nicolaides, Kypros H. 2022. Maternal race and stillbirth: Cohort study and systematic review with meta-analysis. Journal of Clinical Medicine. 11 (12), p. 3452. https://doi.org/jcm11123452
AuthorsArechvo, Anastasija, Nikolaidi, Despoina A, Gil, M., Rolle, V., Syngelaki, A., Akolekar, Ranjit and Nicolaides, Kypros H.
AbstractAccurate identification of independent predictors of stillbirth is needed to define preventive strategies. We aim to examine the independent contribution of maternal race in the risk of stillbirth after adjusting for maternal characteristics and medical history. There are two components to the study: first, prospective screening in 168,966 women with singleton pregnancies coordinated by the Fetal Medicine Foundation (FMF) and second, a systematic review and meta-analysis of studies reporting on race and stillbirth. In the FMF study, logistic regression analysis found that in black women, the risk of stillbirth, after adjustment for confounders, was higher than in white women (odds ratio 1.78, 95% confidence interval 1.50 to 2.11). The risk for other racial groups was not significantly different. The literature search identified 20 studies that provided data on over 6,500,000 pregnancies, but only 10 studies provided risks adjusted for some maternal characteristics; consequently, the majority of these studies did not provide accurate contribution of different racial groups to the prediction of stillbirth. It is concluded that in women of black origin, the risk of stillbirth, after adjustment for confounders, is about twofold higher than in white women. Consequently, closer surveillance should be granted for these women.
KeywordsStillbirth; Pregnancy complications; Singleton pregnancies; Race; Screening
Year2022
JournalJournal of Clinical Medicine
Journal citation11 (12), p. 3452
PublisherMDPI
ISSN2077-0383
Digital Object Identifier (DOI)https://doi.org/jcm11123452
https://doi.org/10.3390/jcm11123452
Official URLhttps://www.mdpi.com/2077-0383/11/12/3452
FunderFetal Medicine Foundation
Publication dates
Online15 Jun 2022
Publication process dates
Accepted13 Jun 2022
Deposited08 Jul 2022
Publisher's version
License
File Access Level
Open
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/916x0/maternal-race-and-stillbirth-cohort-study-and-systematic-review-with-meta-analysis

Download files


Publisher's version
jcm-11-03452-v2.pdf
License: CC BY 4.0
File access level: Open

  • 32
    total views
  • 33
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Evaluation of the RCOG guideline for the prediction of neonates that are small for gestational age and comparison with the competing risks model
Papastefanou, I., Nowacka, U, Buerger, O, Akolekar, R, Wright, D and Nicolaides, KH 2021. Evaluation of the RCOG guideline for the prediction of neonates that are small for gestational age and comparison with the competing risks model. BJOG: An International Journal of Obstetrics & Gynaecology. 128 (13), pp. 2110-2115. https://doi.org/10.1111/1471-0528.16815
Predicting the risk to develop preeclampsia in the first trimester combining promoter variant -98A/C of LGALS13 (placental protein 13), Black ethnicity, previous preeclampsia, obesity, and maternal age
Madar-Shapiro, L., Karady, I., Trahtenherts, A., Syngelaki, A., Akolekar, R., Poon, L., Cohen, R., Sharabi-Nov, A., Huppertz, B., Sammar, M., Juhasz, K., Than, N.G., Papp, Z., Romero, R., Nicolaides, K.H. and Meiri, H. 2018. Predicting the risk to develop preeclampsia in the first trimester combining promoter variant -98A/C of LGALS13 (placental protein 13), Black ethnicity, previous preeclampsia, obesity, and maternal age. Fetal Diagnosis & Therapy. 43 (4), pp. 250-265. https://doi.org/10.1159/000477933
Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature
Beta, J., Lesmes-Heredia, C., Bedetti, C. and Akolekar, R. 2018. Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature. Minerva Ginecologica. 70 (2), pp. 215-219. https://doi.org/10.23736/S0026-4784.17.04178-8
Fetal major cardiac defects and placental dysfunction at 11-13 weeks' gestation
Fantasia, I., Kasapoglu, D., Kasapoglu, T., Syngelaki, A., Akolekar, R. and Nicolaides, K. H. 2018. Fetal major cardiac defects and placental dysfunction at 11-13 weeks' gestation. Ultrasound in Obstetrics and Gynecology. 51 (2), pp. 194-198. https://doi.org/10.1002/uog.18839
ASPRE trial: incidence of preterm pre-eclampsia in patients fulfilling ACOG and NICE criteria according to risk by FMF algorithm
Allen, A., Poon, L. C., Rolnik, D. L., Tan, M. Y., Delgado, J. L., Tsokaki, T., Akolekar, R., Singh, M., Andrade, W., Efeturk, T., Jani, J. C., Plasencia, W., Papaioannou, G., Blazquez, A. R., Carbone, I. F., Wright, D. and Nicolaides, K. H. 2018. ASPRE trial: incidence of preterm pre-eclampsia in patients fulfilling ACOG and NICE criteria according to risk by FMF algorithm. Ultrasound in Obstetrics and Gynecology. 51 (6), pp. 738-742. https://doi.org/10.1002/uog.19019
Comparison of diagnostic accuracy of early screening for pre-eclampsia by NICE guidelines and a method combining maternal factors and biomarkers: results of SPREE
Tan, M. Y., Wright, D., Syngelaki, A., Akolekar, R., Cicero, S., Janga, D., Singh, M., Greco, E., Wright, A., Maclagan, K., Poon, L. C. and Nicolaides, K. H. 2018. Comparison of diagnostic accuracy of early screening for pre-eclampsia by NICE guidelines and a method combining maternal factors and biomarkers: results of SPREE. Ultrasound in Obstetrics and Gynecology. 51 (6), pp. 743-750.
Ultrasonographic estimation of fetal weight: development of new model and assessment of performance of previous models
Hammami, A., Mazer Zumaeta, A., Syngelaki, A., Akolekar, R. and Nicolaides, K. H. 2018. Ultrasonographic estimation of fetal weight: development of new model and assessment of performance of previous models. Ultrasound in Obstetrics and Gynecology. 52 (1), pp. 35-43. https://doi.org/10.1002/uog.19066
Fetal Medicine Foundation fetal and neonatal population weight charts
Nicolaides, K. H., Wright, D., Syngelaki, A., Wright, A. and Akolekar, R. 2018. Fetal Medicine Foundation fetal and neonatal population weight charts. Ultrasound in Obstetrics and Gynecology. 52 (1), pp. 44-51. https://doi.org/10.1002/uog.19073
Screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation
Tan, M.Y., Syngelaki, A., Poon, L.C., Rolnik, D.L., O'Gorman, N., Delgado, J.L., Akolekar, R., Konstantinidou, L., Tsavdaridou, M., Galeva, S., Ajdacka, U., Molina, F.S., Persico, N., Jani, J.C., Plasencia, W., Greco, E., Papaioannou, G., Wright, A., Wright, D. and Nicolaides, K.H. 2018. Screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation. Ultrasound in Obstetrics and Gynecology. 52 (2), pp. 186-195. https://doi.org/10.1002/uog.19112
Reference ranges for the size of the fetal cardiac outflow tracts from 13 to 36 weeks gestation: a single-center study of over 7000 cases
Vigneswaran, T.V., Akolekar, R., Syngelaki, A., Charakida, M., Allan, L.D., Nicolaides, K.H., Zidere, V. and Simpson, J.M. 2018. Reference ranges for the size of the fetal cardiac outflow tracts from 13 to 36 weeks gestation: a single-center study of over 7000 cases. Circulation Cardiovascular Imaging. 11 (7), p. e007575. https://doi.org/10.1161/CIRCIMAGING.118.007575
Comparison of screening for pre-eclampsia at 31-34 weeks' gestation by sFlt-1/PlGF ratio and a method combining maternal factors with sFlt-1 and PlGF
Tan, M.Y., Wright, D., Koutoulas, L., Akolekar, R. and Nicolaides, K.H. 2017. Comparison of screening for pre-eclampsia at 31-34 weeks' gestation by sFlt-1/PlGF ratio and a method combining maternal factors with sFlt-1 and PlGF. Ultrasound in Obstetrics and Gynecology. 49 (2), pp. 201-208. https://doi.org/10.1002/uog.17307
Proposed clinical management of pregnancies after combined screening for pre-eclampsia at 30-34 weeks' gestation
Wright, D., Dragan, I., Syngelaki, A., Akolekar, R. and Nicolaides, K.H. 2017. Proposed clinical management of pregnancies after combined screening for pre-eclampsia at 30-34 weeks' gestation. Ultrasound in Obstetrics and Gynecology. 49 (2), pp. 194-200. https://doi.org/10.1002/uog.17309
Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation
O'Gorman, N., Wright, D., Poon, L.C., Rolnik, D.L., Syngelaki, A., Wright, A., Akolekar, R., Cicero, S., Janga, D., Jani, J., Molina, F.S., de Paco Matallana, C., Papantoniou, N., Persico, N., Plasencia, W., Singh, M. and Nicolaides, K.H. 2017. Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation. Ultrasound in Obstetrics and Gynecology. 49 (6), pp. 751-755. https://doi.org/10.1002/uog.17399
Proposed clinical management of pregnancies after combined screening for pre-eclampsia at 35-37 weeks' gestation
Panaitescu, A.M., Wright, D., Militello, A., Akolekar, R. and Nicolaides, K.H. 2017. Proposed clinical management of pregnancies after combined screening for pre-eclampsia at 35-37 weeks' gestation. Ultrasound in Obstetrics and Gynecology. 50 (3), pp. 383-387. https://doi.org/10.1002/uog.17419
Chronic hypertension and adverse pregnancy outcome: a cohort study
Panaitescu, A.M., Syngelaki, A., Prodan, N., Akolekar, R. and Nicolaides, K.H. 2017. Chronic hypertension and adverse pregnancy outcome: a cohort study. Ultrasound in Obstetrics and Gynecology. 50 (2), pp. 228-235. https://doi.org/10.1002/uog.17493
Impaired placentation in women with chronic hypertension who develop pre-eclampsia
Panaitescu, A.M., Akolekar, R., Kametas, N., Syngelaki, A. and Nicolaides, K.H. 2017. Impaired placentation in women with chronic hypertension who develop pre-eclampsia. Ultrasound in Obstetrics and Gynecology. 50 (4), pp. 496-500. https://doi.org/10.1002/uog.17517
Association of chronic hypertension with birth of small-for-gestational-age neonate
Panaitescu, A.M., Baschat, A.A., Akolekar, R., Syngelaki, A. and Nicolaides, K.H. 2017. Association of chronic hypertension with birth of small-for-gestational-age neonate. Ultrasound in Obstetrics and Gynecology. 50 (3), pp. 361-366. https://doi.org/10.1002/uog.17553
Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia
Rolnik, D.L., Wright, D., Poon, L.C., O'Gorman, N., Syngelaki, A., de Paco Matallana, C., Akolekar, R., Cicero, S., Janga, D., Singh, M., Molina, F.S., Persico, N., Jani, J.C., Plasencia, W., Papaioannou, G., Tenenbaum-Gavish, K., Meiri, H., Gizurarson, S., Maclagan, K. and Nicolaides, K.H. 2017. Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. The New England Journal of Medicine. 377 (7), pp. 613-622. https://doi.org/10.1056/NEJMoa1704559
Aspirin for evidence-based preeclampsia prevention trial: effect of aspirin in prevention of preterm preeclampsia in subgroups of women according to their characteristics and medical and obstetrical history.
Poon, L.C., Wright, D., Rolnik, D.L., Syngelaki, A., Delgado, J.L., Tsokaki, T., Leipold, G., Akolekar, R., Shearing, S., De Stefani, L., Jani, J.C., Plasencia, W., Evangelinakis, N., Gonzalez-Vanegas, O., Persico, N., Nicolaides, K.H. and Allen, A. 2017. Aspirin for evidence-based preeclampsia prevention trial: effect of aspirin in prevention of preterm preeclampsia in subgroups of women according to their characteristics and medical and obstetrical history. American Journal of Obstetrics & Gynecology. 217 (5), pp. 585.e1- 5.. https://doi.org/10.1016/j.ajog.2017.07.038
Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin
Balani, J., Hyer, S., Syngelaki, A., Akolekar, R., Nicolaides, K. H., Johnson, A. and Shehata, H. 2017. Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin. Obstetric Medicine. 10, pp. 170-173. https://doi.org/10.1177/1753495X17725465