Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature

Journal article

Beta, J., Lesmes-Heredia, C., Bedetti, C. and Akolekar, R. 2018. Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature. Minerva Ginecologica. 70 (2), pp. 215-219. https://doi.org/10.23736/S0026-4784.17.04178-8
AuthorsBeta, J., Lesmes-Heredia, C., Bedetti, C. and Akolekar, R.
Abstract

Objectives: To estimate the risk of miscarriage after amniocentesis or chorionic villus sampling (CVS) based on a systematic review of the literature.

Methods: A search of MEDLINE, EMBASE, and The Cochrane Library (2000-2017) was carried out to identify studies reporting complications following CVS or amniocentesis. The inclusion criteria for the systematic review were studies reporting results from large controlled studies (n1,000 invasive procedures) and those reporting data for pregnancy loss prior to 24 weeks’ gestation. Data for cases that had invasive procedure and controls were inputted in contingency tables and risk of miscarriage was estimated for each study. Summary statistics were calculated after taking into account the weighting for each study included in the systematic review. Procedure-related risk of miscarriage was estimated as a weighted risk difference from the summary statistics for cases and controls.

Results: The electronic search from the databases yielded 2,465 potential citations of which 2,431 were excluded, leaving 34 studies for full-text review. The final review included 10 studies for amniocentesis and 6 studies for CVS, which were used to estimate risk of miscarriage in pregnancies that had an invasive procedure and the control pregnancies that did not. The procedure-related risk of miscarriage following amniocentesis was 0.35% (95% confidence interval [CI]: 0.07 to 0.63) and that following CVS was 0.35% (95%C CI: -0.31 to 1.00).

Conclusion: The procedure-related risks of miscarriage following amniocentesis and CVS are lower than currently quoted to women.

KeywordsAmniocentesis; Chorionic villus sampling; CVS; Miscarriage; Pregnancy loss; Fetal loss; Procedure-related loss; Invasive diagnostic procedure; Prenatal diagnosis
Year2018
JournalMinerva Ginecologica
Journal citation70 (2), pp. 215-219
PublisherEdizioni Minerva Medica
ISSN0026-4784
Digital Object Identifier (DOI)https://doi.org/10.23736/S0026-4784.17.04178-8
Official URLhttp://doi.org/10.23736/S0026-4784.17.04178-8
Publication dates
OnlineApr 2018
Publication process dates
Deposited28 May 2020
Accepted author manuscript
Output statusPublished
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