Maternal and neonatal complications following Kielland's rotational forceps delivery: A systematic review and meta‐analysis

Journal article

Giacchino, Tara, Karkia, Rebecca, Ahmed, Hasib and Akolekar, R. 2023. Maternal and neonatal complications following Kielland's rotational forceps delivery: A systematic review and meta‐analysis. BJOG: An International Journal of Obstetrics & Gynaecology. 130 (8), pp. 856-864. https://doi.org/10.1111/1471-0528.17402
AuthorsGiacchino, Tara, Karkia, Rebecca, Ahmed, Hasib and Akolekar, R.
Abstract

Background
There is conflicting evidence regarding the safety of Kielland's rotational forceps delivery (KRFD) in comparison with other modes of delivery for the management of persistent fetal malposition in the second stage of labour.

Objectives
To derive estimates of risks of maternal and neonatal complications following KRFD, compared with rotational ventouse delivery (RVD), non-rotational forceps delivery (NRFD) or a second-stage caesarean section (CS), from a systematic review and meta-analysis of the literature.

Search Strategy
Standard search methodology, as recommended by the Cochrane Handbook for Systematic Reviews of Interventions.

Selection Criteria
Case series, prospective or retrospective cohort studies and population-based studies.

Data Collection and Analysis
A meta-analysis using a random-effects model was used to derive weighted pooled estimates of maternal and neonatal complications.

Main Results
Thirteen studies were included. For postpartum haemorrhage there was no significant difference between Kielland's and ventouse delivery; the rate was lower in Kielland's delivery compared with non-rotational forceps (RR 0.79, 95% CI 0.65–0.95) and second-stage CS (RR 0.45, 95% CI 0.36–0.58). There were no differences in the rates of anal sphincter injuries or admission to neonatal intensive care. Rates of shoulder dystocia were higher with Kielland's delivery compared with ventouse delivery (RR 1.79, 95% CI 1.08–2.98), but rates of neonatal birth trauma were lower (RR 0.49, 95% CI 0.26–0.91). There were no differences seen in the rates of 5-min APGAR score < 7 between Kielland's delivery and other instrumental births, but they were lower when compared with second-stage CS (RR 0.47, 95% CI 0.23–0.97).

Conclusions
Kielland's rotational forceps delivery is a safe option for the management of fetal malposition in the second stage of labour.

KeywordsBirth trauma; Fetal malposition; Kielland's forceps; Postpartum haemorrhage; Rotational forceps delivery
Year2023
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Journal citation130 (8), pp. 856-864
PublisherWiley
ISSN1470-0328
1471-0528
Digital Object Identifier (DOI)https://doi.org/10.1111/1471-0528.17402
Official URLhttps://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.17402
Publication dates
Online13 Feb 2023
PrintJul 2023
Publication process dates
Accepted13 Oct 2022
Deposited04 Dec 2023
Publisher's version
License
File Access Level
Open
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/960y4/maternal-and-neonatal-complications-following-kielland-s-rotational-forceps-delivery-a-systematic-review-and-meta-analysis

Download files

Publisher's version
BJOG - 2023 - Giacchino - Maternal and neonatal complications following Kielland s rotational forceps delivery A.pdf
License: CC BY-NC-ND 4.0
File access level: Open

  • 171
    total views
  • 67
    total downloads
  • 10
    views this month
  • 3
    downloads this month

Export as

Related outputs

Preeclampsia screening taking into account ethnicity and socioeconomic status - a comparison of the competing-risks model and risk factor scoring.
Arechvo, Anastasija, Syngelaki, Argyro, Akolekar, Ranjit, Von Dadelszen, Peter, Nicolaides, Kypros H. and Magee, Laura A. 2025. Preeclampsia screening taking into account ethnicity and socioeconomic status - a comparison of the competing-risks model and risk factor scoring. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC. p. 103087. https://doi.org/10.1016/j.jogc.2025.103087
Blood pressure cutoffs at 11-13 weeks of gestation and risk of preeclampsia
Slade, L., Syngelaki, Argyro, Wilson, Milly, Mistry, Hiten D., Akolekar, Ranjit, von Dadelszen, Peter, Nicolaides, Kypros H. and Magee, L. 2025. Blood pressure cutoffs at 11-13 weeks of gestation and risk of preeclampsia. American Journal of Obstetrics and Gynecology. 232 (2), pp. 214.e1-214.e10. https://doi.org/10.1016/j.ajog.2024.04.032
Routine 36‐week scan: prediction of small‐for‐gestational‐age neonate
Adjahou, S., Syngelaki, A., Nanda, M., Papavasileiou, D., Akolekar, R. and Nicolaides, K. 2024. Routine 36‐week scan: prediction of small‐for‐gestational‐age neonate. Ultrasound in Obstetrics & Gynecology. 65 (1), pp. 20-29. https://doi.org/10.1002/uog.29134
Advances and challenges in prenatal detection and genetic diagnosis of upper limb anomalies: Analysis of a south London and Kent Cohort
Ruscitti, F., Giacchino, Tara, Koutoulas, Lenia, Homfray, Tessa, Akolekar, R., Sankaran, Srividhya, Fowler, Emma, Bint, Susan, Walsh, Cheryl, Garagnani, Lorenzo, Forzano, Francesca, Holder-Espinasse, Muriel and Elmakky, Amira 2024. Advances and challenges in prenatal detection and genetic diagnosis of upper limb anomalies: Analysis of a south London and Kent Cohort. Prenatal Diagnosis. 45 (1), pp. 15-26. https://doi.org/10.1002/pd.6709
The potential impact of universal screening for vasa previa in the prevention of stillbirths
Zhang, Weiyu, Oyelese, Y., Javinani, A., Shamshirsaz, Alireza and Akolekar, Ranjit 2024. The potential impact of universal screening for vasa previa in the prevention of stillbirths. Journal of Perinatal Medicine. https://doi.org/10.1515/jpm-2024-0203
Gestational diabetes mellitus: relationship of adverse outcomes with severity of disease.
Karkia, Rebecca, Giacchino, Tara, Hii, Frederick, Bradshaw, Charline, Ramadan, Ghada and Akolekar, R. 2024. Gestational diabetes mellitus: relationship of adverse outcomes with severity of disease. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 37 (1), p. 2356031. https://doi.org/10.1080/14767058.2024.2356031
Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study.
Montgomery-Csobán, Tünde, Kavanagh, Kimberley, Murray, Paul, Robertson, Chris, Barry, Sarah J E, Vivian Ukah, U, Payne, Beth A, Nicolaides, Kypros H, Syngelaki, Argyro, Ionescu, Olivia, Akolekar, Ranjit, Hutcheon, Jennifer A, Magee, Laura A, von Dadelszen, Peter and PIERS Consortium 2024. Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study. The Lancet. Digital health. 6 (4), pp. e238-e250. https://doi.org/10.1016/S2589-7500(23)00267-4
Vasa previa in singleton pregnancies: Diagnosis and clinical management based on an international expert consensus
Oyelese, Yinka, Javinani, Ali, Gudanowski, Brittany, Krispin, Eyal, Rebarber, Andrei, Akolekar, R., Catanzarite, Val, D'Souza, Rohan, Bronsteen, Richard, Odibo, Anthony, Scheier, Matthias A, Hasegawa, Junichi, Jauniaux, Eric, Lees, Christoph, Srinivasan, Deepa, Daly-Jones, Elizabeth, Duncombe, Gregory, Melcer, Yaacov, Maymon, Ron, Silver, Robert, Prefumo, Federico, Tachibana, Daisuke, Henrich, Wolfgang, Cincotta, Robert, Shainker, Scott A, Ranzini, Angela C, Roman, Ashley S, Chmait, Ramen, Hernandez-Andrade, Edgar A, Rolnik, Daniel L, Sepulveda, Waldo and Shamshirsaz, Alireza A 2024. Vasa previa in singleton pregnancies: Diagnosis and clinical management based on an international expert consensus. American Journal of Obstetrics and Gynecology. 231 (6), pp. 638.e1-638.e24. https://doi.org/10.1016/j.ajog.2024.03.013
Interim analysis of serum placental growth factor values for use in pre-eclampsia screening
Golob, E., Jones, S., Ganapathy, R. and Akolekar, R. 2023. Interim analysis of serum placental growth factor values for use in pre-eclampsia screening. Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.27570
Gestational diabetes mellitus: Association with maternal and neonatal complications
Karkia, R., Giacchino, T., Shah, Saadia, Gough, Andrew, Ramadan, G. and Akolekar, R. 2023. Gestational diabetes mellitus: Association with maternal and neonatal complications. Medicina (Kaunas, Lithuania). 59 (12), p. 2096. https://doi.org/10.3390/medicina59122096
Pregnancy-An ideal period to identify women at risk for chronic hypertension
Charakida, M., Wright, A., Magee, L., Syngelaki, A., von Dadelszen, P., Akolekar, R., Nicolaides, K. and Wright, David 2023. Pregnancy-An ideal period to identify women at risk for chronic hypertension. Hypertension. 81 (2), pp. 311-318. https://doi.org/10.1161/HYPERTENSIONAHA.123.21573
Placental growth factor testing at 19–23 weeks of gestation as a guide to subsequent care in pregnancy: A prospective observational study
Magee, L., Syngelaki, Argyro, Akolekar, R., von Dadelszen, P. and Nicolaides, K. 2023. Placental growth factor testing at 19–23 weeks of gestation as a guide to subsequent care in pregnancy: A prospective observational study. BJOG: An International Journal of Obstetrics & Gynaecology. 131 (6), pp. 803-810. https://doi.org/10.1111/1471-0528.17684
Management of preterm labor: Clinical practice guideline and recommendation by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine Foundation
Dagklis, Themistoklis, Akolekar, Ranjit, Villalain, Cecilia, Tsakiridis, Ioannis, Kesrouani, Assaad, Tekay, Aydin, Plasencia, Walter, Wellmann, Sven, Kusuda, Satoshi, Jekova, Nelly, Prefumo, Federico, Volpe, Nicola, Chaveeva, Petya, Allegaert, Karel, Khalil, Asma and Sen, Cihat 2023. Management of preterm labor: Clinical practice guideline and recommendation by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine Foundation. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 291, pp. 196-205. https://doi.org/10.1016/j.ejogrb.2023.10.013
OP08.09: Causes of death and perinatal mortality rate in patients with prenatally diagnosed vasa previa: a systematic review and meta‐analysis
Javinani, A., Conyers, S., Jamali, M., Zargarzadeh, N., Akolekar, R., Hasegawa, J., Meltcer, Y., Maymon, R., Bronsteen, R., Roman, A., Shamshirsaz, A. and Oyelese, Y. 2023. OP08.09: Causes of death and perinatal mortality rate in patients with prenatally diagnosed vasa previa: a systematic review and meta‐analysis. Ultrasound in Obstetrics & Gynecology. 62 (S1), pp. 68-69. https://doi.org/10.1002/uog.26518
Incidence of vasa praevia: a systematic review and meta-analysis
Zhang, Weiyu, Giacchino, Tara, Chanyarungrijn, P. A., Ionescu, Olivia and Akolekar, R. 2023. Incidence of vasa praevia: a systematic review and meta-analysis. BMJ Open. 13 (9), p. e075245. https://doi.org/10.1136/bmjopen-2023-075245
Prediction of hypertensive disorders after screening at 36 weeks' gestation: comparison of angiogenic markers with competing‐risks model
Schiattarella, A., Magee, L., Wright, A., Syngelaki, A., Akolekar, R., von Dadelszen, P. and Nicolaides, K. H. 2023. Prediction of hypertensive disorders after screening at 36 weeks' gestation: comparison of angiogenic markers with competing‐risks model. Ultrasound in Obstetrics & Gynecology. 62 (3), pp. 345-352. https://doi.org/10.1002/uog.26291
Incidence of pre‐eclampsia: effect of deprivation
Arechvo, A., Syngelaki, A., Wright, A., Magee, L., von Dadelszen, P., Akolekar, R., Wright, D. and Nicolaides, K. H. 2023. Incidence of pre‐eclampsia: effect of deprivation. Ultrasound in Obstetrics & Gynecology. 61 (1), pp. 26-32. https://doi.org/10.1002/uog.26084
Preeclampsia prevention by timed birth at term
Magee, L., Wright, David, Syngelaki, A., von Dadelszen, P., Akolekar, R., Wright, A. and Nicolaides, K. 2023. Preeclampsia prevention by timed birth at term. Hypertension. 80 (5), pp. 969-78. https://doi.org/10.1161/HYPERTENSIONAHA.122.20565
Relation of antepartum stillbirth to birthweight and gestational age: Prospective cohort study.
Papastefanou, I., Ashoor, Ghalia, Syngelaki, Argyro, Akolekar, R. and Nicolaides, Kypros H 2023. Relation of antepartum stillbirth to birthweight and gestational age: Prospective cohort study. BJOG: An International Journal of Obstetrics & Gynaecology. 131 (2), pp. 200-206. https://doi.org/10.1111/1471-0528.17652
Maternal and neonatal complications in pregnancies with and without pre-gestational diabetes mellitus
Karkia, Rebecca, Giacchino, Tara, Watson, Helen, Gough, Andrew, Ramadan, Ghada and Akolekar, R. 2023. Maternal and neonatal complications in pregnancies with and without pre-gestational diabetes mellitus. Journal of Perinatal Medicine. https://doi.org/10.1515/jpm-2023-0183
Efficiency of the cerebroplacental ratio in Identifying high-risk late-term pregnancies
Martin-Alonso, R., Rolle, V., Akolekar, R., de Paco Matallana, Catalina, Fernández-Buhigas, I., Sánchez-Camps, Maria Isabel, Giacchino, T., Rodríguez-Fernández, Miguel, Blanco-Carnero, Jose Eliseo, Santacruz, Belén and Gil, María M. 2023. Efficiency of the cerebroplacental ratio in Identifying high-risk late-term pregnancies. Medicina (Kaunas, Lithuania). 59 (9), p. 1670. https://doi.org/10.3390/medicina59091670
Incidence and causes of perinatal death in prenataly diagnosed Vasa Previa: A systematic review and meta-analysis
Conyers, Steffany, Oyelese, Yinka, Javinani, Ali, Jamali, Marzieh, Zargarzadeh, Nikan, Akolekar, Ranjit, Hasegawa, Junichi, Melcer, Yaakov, Maymon, Ron, Bronsteen, Richard, Roman, Ashley and Shamshirsaz, Alireza A 2023. Incidence and causes of perinatal death in prenataly diagnosed Vasa Previa: A systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. 230 (1), pp. 58-65. https://doi.org/10.1016/j.ajog.2023.06.015
Competing-risks model for pre-eclampsia and adverse pregnancy outcomes.
Syngelaki, A., Magee, L., Dadelszen, P von, Akolekar, R., Wright, A, Wright, D and Nicolaides, K H 2022. Competing-risks model for pre-eclampsia and adverse pregnancy outcomes. Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.26036
Preterm and term pre-eclampsia: relative burdens of maternal and perinatal complications.
von Dadelszen, P., Syngelaki, Argyro, Akolekar, R., Magee, L. and Nicolaides, Kypros H 2022. Preterm and term pre-eclampsia: relative burdens of maternal and perinatal complications. BJOG: An International Journal of Obstetrics & Gynaecology. 130 (5), pp. 524-530. https://doi.org/10.1111/1471-0528.17370
Incidence of stillbirth: effect of deprivation
Arechvo, A, Nikolaidi, D A, Gil, M., Rolle, V, Syngelaki, A, Akolekar, R. and Nicolaides, K H 2022. Incidence of stillbirth: effect of deprivation. Ultrasound in Obstetrics & Gynecology. 61 (2), pp. 198-206. https://doi.org/10.1002/uog.26096
Estimated fetal weight at mid-gestation in prediction of pre-eclampsia in singleton pregnancy
Frei, L, Wright, A, Syngelaki, A., Akolekar, R. and Nicolaides, K H 2022. Estimated fetal weight at mid-gestation in prediction of pre-eclampsia in singleton pregnancy. Ultrasound in Obstetrics & Gynecology. 59 (3), pp. 335-341. https://doi.org/10.1002/uog.24829
Competing-risks model for prediction of small-for-gestational-age neonates at 36 weeks' gestation.
Papastefanou, I., Thanopoulou, V, Dimopoulou, S, Syngelaki, A., Akolekar, R. and Nicolaides, K H 2022. Competing-risks model for prediction of small-for-gestational-age neonates at 36 weeks' gestation. Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.26057
Effect of race on the measurement of angiogenic factors for prediction and diagnosis of pre‐eclampsia
Wright, Alan, von Dadelszen, P., Magee, L., Syngelaki, A., Akolekar, R., Wright, Dave and Nicolaides, K. 2022. Effect of race on the measurement of angiogenic factors for prediction and diagnosis of pre‐eclampsia. BJOG: An International Journal of Obstetrics & Gynaecology. 130 (1), pp. 78-87. https://doi.org/10.1111/1471-0528.17296
Personalized stratification of pregnancy care for small for gestational age neonates from biophysical markers at mid-gestation
Papastefanou, Ioannis, Wright, David, Syngelaki, Argyro, Akolekar, Ranjit and Nicolaides, Kypros H 2022. Personalized stratification of pregnancy care for small for gestational age neonates from biophysical markers at mid-gestation. American Journal of Obstetrics and Gynecology. 229 (1), pp. 57.e1-57.14. https://doi.org/10.1016/j.ajog.2022.12.318
The implications of the Fetal Medicine Foundation 35-36 week preeclampsia prediction competing risk model on timing of birth.
von Dadelszen, Peter, Syngelaki, Argyro, Wright, Alan, Akolekar, Ranjit, Magee, Laura A, Wright, David and Nicolaides, Kypros H 2022. The implications of the Fetal Medicine Foundation 35-36 week preeclampsia prediction competing risk model on timing of birth. American Journal of Obstetrics and Gynecology. 228 (4), pp. 457.e1-457.e7. https://doi.org/S0002-9378(22)00804-3
Predictive performance for placental dysfunction related stillbirth of the competing risks model for small‐for‐gestational‐age fetuses
Nicolaides, Kypros H., Papastefanou, I., Syngelaki, Argyro, Ashoor, Ghalia and Akolekar, Ranjit 2022. Predictive performance for placental dysfunction related stillbirth of the competing risks model for small‐for‐gestational‐age fetuses. BJOG: An International Journal of Obstetrics & Gynaecology. 129 (9), pp. 1530-1537. https://doi.org/10.1111/1471-0528.17066
Second‐trimester contingent screening for small‐for‐gestational‐age neonate
Nowacka, U., Papastefanou, I., Bouariu, A., Syngelaki, A., Akolekar, R. and Nicolaides, K. H. 2022. Second‐trimester contingent screening for small‐for‐gestational‐age neonate. Ultrasound in Obstetrics & Gynecology. 59 (2), pp. 177-184. https://doi.org/10.1002/uog.23730
Perinatal outcome of pregnancies with prenatal diagnosis of vasa previa: systematic review and meta‐analysis
Zhang, W., Geris, S., Al‐Emara, N., Ramadan, G., Sotiriadis, A. and Akolekar, R. 2021. Perinatal outcome of pregnancies with prenatal diagnosis of vasa previa: systematic review and meta‐analysis. Ultrasound in Obstetrics & Gynecology. 57 (5), pp. 710-719. https://doi.org/10.1002/uog.22166
Development and validation of a model for prediction of placental dysfunction-related stillbirth from maternal factors, fetal weight and uterine artery Doppler at mid-gestation.
Ashoor, G, Syngelaki, A., Papastefanou, I., Nicolaides, K H and Akolekar, R. 2021. Development and validation of a model for prediction of placental dysfunction-related stillbirth from maternal factors, fetal weight and uterine artery Doppler at mid-gestation. Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.24795
Risk of fetal loss after chorionic villus sampling in twin pregnancies derived from propensity score matching analysis.
Gil, M., Rodríguez-Fernández, M, Elger, T, Akolekar, R., Syngelaki, A., De Paco Matallana, C, Molina, F S, Gallardo Arozena, M, Chaveeva, P, Persico, N, Syngelaki, A., Accurti, V, Kagan, O., Prodan, N., Cruz, J and Nicolaides, K H 2021. Risk of fetal loss after chorionic villus sampling in twin pregnancies derived from propensity score matching analysis. Ultrasound in Obstetrics & Gynecology. 59 (2), pp. 162-168. https://doi.org/10.1002/uog.24826
Cell‐free DNA testing of maternal blood in screening for trisomies in twin pregnancy: updated cohort study at 10–14 weeks and meta‐analysis
Judah, H., Gil, M., Syngelaki, A., Galeva, S., Jani, J., Akolekar, R. and Nicolaides, K. H. 2021. Cell‐free DNA testing of maternal blood in screening for trisomies in twin pregnancy: updated cohort study at 10–14 weeks and meta‐analysis. Ultrasound in Obstetrics & Gynecology. 58 (2), pp. 178-189. https://doi.org/10.1002/uog.23648
Fetal loss after chorionic villus sampling in twin pregnancies
Elger, T., Akolekar, R., Syngelaki, A., De Paco Matallana, C., Molina, F. S., Gallardo Arozena, M., Chaveeva, P., Persico, N., Accurti, V., Kagan, O., Prodan, N., Cruz, J. and Nicolaides, K. H. 2021. Fetal loss after chorionic villus sampling in twin pregnancies. Ultrasound in Obstetrics & Gynecology. 58 (1), pp. 48-55. https://doi.org/10.1002/uog.23694
Kielland’s rotational forceps delivery: comparison of maternal and neonatal outcomes with pregnancies delivering by non-rotational forceps
Giacchino, Tara, Karkia, Rebecca, Zhang, Weiyu, Ahmed, Hasib and Akolekar, Ranjit 2021. Kielland’s rotational forceps delivery: comparison of maternal and neonatal outcomes with pregnancies delivering by non-rotational forceps. Journal of Obstetrics and Gynaecology. 42 (3), pp. 379-384. https://doi.org/10.1080/01443615.2021.1907557
Reference ranges for the pulsed wave doppler of the fetal cardiac inflow and outflow tracts from 13 to 36 weeks gestation: Short title: Zidere, Fetal inflow and outflow tract, Pulsed wave Doppler, z scores.
Zidere, V., Vigneswaran, T. V., Syngelaki, A., Charakida, M., Allan, L. D., Nicolaides, K. H., Simpson, J. M and Akolekar, R. 2021. Reference ranges for the pulsed wave doppler of the fetal cardiac inflow and outflow tracts from 13 to 36 weeks gestation: Short title: Zidere, Fetal inflow and outflow tract, Pulsed wave Doppler, z scores. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. https://doi.org/10.1016/j.echo.2021.04.017
Value of routine ultrasound examination at 35-37 weeks' gestation in diagnosis of fetal abnormalities
Ficara, A., Syngelaki, A., Hammami, A., Akolekar, R. and Nicolaides, K. H. 2020. Value of routine ultrasound examination at 35-37 weeks' gestation in diagnosis of fetal abnormalities. Ultrasound in Obstetrics and Gynecology. 55 (1), pp. 75-80. https://doi.org/10.1002/uog.20857
Diagnosis of fetal defects in twin pregnancies at routine 11-13-week ultrasound examination
Syngelaki, A., Cimpoca, B., Litwinska, E., Akolekar, R. and Nicolaides, K. H. 2020. Diagnosis of fetal defects in twin pregnancies at routine 11-13-week ultrasound examination. Ultrasound in Obstetrics and Gynecology. 55 (4), pp. 474-481. https://doi.org/10.1002/uog.21938
Metformin use in obese mothers is associated with improved cardiovascular profile in the offspring
Panagiotopoulou, O., Syngelaki, A., Georgiopoulos, G., Simpson, J., Akolekar, R., Shehata, H., Nicolaides, K. H. and Charakida, M. 2020. Metformin use in obese mothers is associated with improved cardiovascular profile in the offspring. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/j.ajog.2020.01.054
ISUOG Consensus Statement on organization of routine and specialist obstetric ultrasound services in the context of COVID-19
Abu-Rustum, R. S., Akolekar, R., Sotiriadis, A., Salomon, L. J., Da Silva Costa, F., Wu, Q., Frusca, T., Bilardo, C. M., Prefumo, F. and Poon, L. C. 2020. ISUOG Consensus Statement on organization of routine and specialist obstetric ultrasound services in the context of COVID-19. Ultrasound in Obstetrics and Gynecology. https://doi.org/10.1002/uog.22029
Comparison of different methods of measuring angle of progression in prediction of labor outcome
Frick, A., Kostiv, V., Vojtassakova, D., Akolekar, R. and Nicolaides, K. H. 2020. Comparison of different methods of measuring angle of progression in prediction of labor outcome. Ultrasound in Obstetrics & Gynecology. 55 (3), pp. 391-400. https://doi.org/10.1002/uog.21913
Value of routine ultrasound examination at 35–37 weeks' gestation in diagnosis of non‐cephalic presentation
De Castro, H., Ciobanu, A., Formuso, C., Akolekar, R. and Nicolaides, K. H. 2020. Value of routine ultrasound examination at 35–37 weeks' gestation in diagnosis of non‐cephalic presentation. Ultrasound in Obstetrics & Gynecology. 55 (2), pp. 248-256. https://doi.org/10.1002/uog.21902
Impaired placental perfusion and major fetal cardiac defects
Fantasia, I., Andrade, W., Syngelaki, A., Akolekar, R. and Nicolaides, K.H. 2019. Impaired placental perfusion and major fetal cardiac defects. Ultrasound in Obstetrics and Gynecology. 53 (1), pp. 68-72. https://doi.org/10.1002/uog.20149
Routine first-trimester screening for fetal trisomies in twin pregnancy: cell-free DNA test contingent on results from combined test
Galeva, S., Konstantinidou, L., Gil, M.M., Akolekar, R. and Nicolaides, K.H. 2019. Routine first-trimester screening for fetal trisomies in twin pregnancy: cell-free DNA test contingent on results from combined test. Ultrasound in Obstetrics and Gynecology. 53 (2), pp. 208-213. https://doi.org/10.1002/uog.20160
Fetal Medicine Foundation reference ranges for umbilical artery and middle cerebral artery pulsatility index and cerebroplacental ratio
Ciobanu, A., Wright, A., Syngelaki, A., Wright, D., Akolekar, R. and Nicolaides, K.H. 2019. Fetal Medicine Foundation reference ranges for umbilical artery and middle cerebral artery pulsatility index and cerebroplacental ratio. Ultrasound in Obstetrics and Gynecology. 53 (4), pp. 465-472. https://doi.org/10.1002/uog.20157
Prediction of adverse perinatal outcome by cerebroplacental ratio in women undergoing induction of labor
Fiolna, M., Kostiv, V., Anthoulakis, C., Akolekar, R. and Nicolaides, K.H. 2019. Prediction of adverse perinatal outcome by cerebroplacental ratio in women undergoing induction of labor. Ultrasound in Obstetrics and Gynecology. 53 (4), pp. 473-480. https://doi.org/10.1002/uog.20173
Prediction of small for gestational age neonates: screening by maternal factors, fetal biometry, and biomarkers at 35-37 weeks' gestation
Ciobanu, A., Rouvali, A., Syngelaki, A., Akolekar, R. and Nicolaides, K.H. 2019. Prediction of small for gestational age neonates: screening by maternal factors, fetal biometry, and biomarkers at 35-37 weeks' gestation. American Journal of Obstetrics & Gynecology. 220 (5), pp. 486.e1-486.e11. https://doi.org/10.1016/j.ajog.2019.01.227
Prediction of small-for-gestational-age neonates at 35-37 weeks' gestation: contribution of maternal factors and growth velocity between 20 and 36 weeks
Ciobanu, A., Formuso, C., Syngelaki, A., Akolekar, R. and Nicolaides, K.H. 2019. Prediction of small-for-gestational-age neonates at 35-37 weeks' gestation: contribution of maternal factors and growth velocity between 20 and 36 weeks. Ultrasound in Obstetrics and Gynecology. 53 (4), pp. 488-495. https://doi.org/10.1002/uog.20243
Routine assessment of cerebroplacental ratio at 35-37 weeks' gestation in the prediction of adverse perinatal outcome
Akolekar, R., Ciobanu, A., Zingler, E., Syngelaki, A. and Nicolaides, K.H. 2019. Routine assessment of cerebroplacental ratio at 35-37 weeks' gestation in the prediction of adverse perinatal outcome. American Journal of Obstetrics & Gynecology. 221 (1), pp. 65.e1-65.e18. https://doi.org/10.1016/j.ajog.2019.03.002
Routine ultrasound at 32 vs 36 weeks' gestation: prediction of small-for-gestational-age neonates
Ciobanu, A., Khan, N., Syngelaki, A., Akolekar, R. and Nicolaides, K. H. 2019. Routine ultrasound at 32 vs 36 weeks' gestation: prediction of small-for-gestational-age neonates. Ultrasound in Obstetrics and Gynecology. 53 (6), pp. 761-768. https://doi.org/10.1002/uog.20258
Prediction of small-for-gestational-age neonates at 35-37 weeks' gestation: contribution of maternal factors and growth velocity between 32 and 36 weeks
Ciobanu, A., Anthoulakis, C., Syngelaki, A., Akolekar, R. and Nicolaides, K.H. 2019. Prediction of small-for-gestational-age neonates at 35-37 weeks' gestation: contribution of maternal factors and growth velocity between 32 and 36 weeks. Ultrasound in Obstetrics and Gynecology. 53 (5), pp. 630-637. https://doi.org/10.1002/uog.20267
Maternal and neonatal complications of fetal macrosomia: cohort study
Beta, J., Khan, N., Fiolna, M., Khalil, A., Ramadan, G. and Akolekar, R. 2019. Maternal and neonatal complications of fetal macrosomia: cohort study. Ultrasound in Obstetrics and Gynecology. 54 (3), pp. 319-325. https://doi.org/10.1002/uog.20279
Procedure-related risk of miscarriage following chorionic villus sampling and amniocentesis
Beta, J., Zhang, W., Geris, S., Kostiv, V. and Akolekar, R. 2019. Procedure-related risk of miscarriage following chorionic villus sampling and amniocentesis. Ultrasound in Obstetrics and Gynecology. 54 (4), pp. 452-457. https://doi.org/10.1002/uog.20293
Biomarkers of impaired placentation at 35-37 weeks' gestation in the prediction of adverse perinatal outcome
Ciobanou, A., Jabak, S., De Castro, H., Frei, L., Akolekar, R. and Nicolaides, K. H. 2019. Biomarkers of impaired placentation at 35-37 weeks' gestation in the prediction of adverse perinatal outcome. Ultrasound in Obstetrics and Gynecology. 54 (1), pp. 79-86. https://doi.org/10.1002/uog.20346
Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta-analysis
Salomon, L. J., Sotiriadis, A., Wulff, C. B., Odibo, A. and Akolekar, R. 2019. Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta-analysis. Ultrasound in Obstetrics and Gynecology. 54 (4), pp. 442-451. https://doi.org/10.1002/uog.20353
Prediction of large-for-gestational-age neonate by routine third-trimester ultrasound
Khan, N., Ciobanu, A., Karampitsakos, T., Akolekar, R. and Nicolaides, K. H. 2019. Prediction of large-for-gestational-age neonate by routine third-trimester ultrasound. Ultrasound in Obstetrics and Gynecology. 54 (2), pp. 326-333. https://doi.org/10.1002/uog.20377
Two-stage approach for prediction of small-for-gestational-age neonate and adverse perinatal outcome by routine ultrasound examination at 35-37 weeks' gestation
Akolekar, R., Panaitescu, A. M., Ciobanu, A., Syngelaki, A. and Nicolaides, K. H. 2019. Two-stage approach for prediction of small-for-gestational-age neonate and adverse perinatal outcome by routine ultrasound examination at 35-37 weeks' gestation. Ultrasound in Obstetrics and Gynecology. 54, pp. 484-491. https://doi.org/10.1002/uog.20391
Prevention of stillbirths: impact of a two-stage screening for vasa previa
Zhang, W., Geris, S., Beta, J., Ramadan, G., Nicolaides, K. H. and Akolekar, R. 2019. Prevention of stillbirths: impact of a two-stage screening for vasa previa. Ultrasound in Obstetrics and Gynecology. 55 (5), pp. 605-612. https://doi.org/10.1002/uog.21953
Impact of prospective measurement of outflow tracts in the prediction of coarctation of the aorta
Vigneswaran, T. V., Zidere, V., Chivers, S., Charakida, M., Akolekar, R. and Simpson, J. M. 2019. Impact of prospective measurement of outflow tracts in the prediction of coarctation of the aorta. Ultrasound in Obstetrics and Gynecology. https://doi.org/10.1002/uog.21957
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with high nuchal translucency, tricuspid regurgitation and abnormal flow in the ductus venosus
Minnella, G. P., Crupano, F. M., Syngelaki, A., Zidere, V., Akolekar, R. and Nicolaides, K. H. 2019. Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with high nuchal translucency, tricuspid regurgitation and abnormal flow in the ductus venosus. Ultrasound in Obstetrics and Gynecology. 55 (5), pp. 637-644. https://doi.org/10.1002/uog.21956
Screening for pre-eclampsia using sFlt-1/PlGF ratio cut-off of 38 at 30-37 weeks' gestation
Dragan, I., Georgiou, T., Prodan, N., Akolekar, R. and Nicolaides, K. H. 2017. Screening for pre-eclampsia using sFlt-1/PlGF ratio cut-off of 38 at 30-37 weeks' gestation. Ultrasound in Obstetrics and Gynecology. 49 (1), pp. 73-77. https://doi.org/10.1002/uog.17301
Uterine artery pulsatility index at 30-34 weeks' gestation in the prediction of adverse perinatal outcome
Valiño, N., Giunta, G., Gallo, D. M., Akolekar, R. and Nicolaides, K. H. 2016. Uterine artery pulsatility index at 30-34 weeks' gestation in the prediction of adverse perinatal outcome. Ultrasound in Obstetrics and Gynecology. 47 (3), pp. 308-315. https://doi.org/10.1002/uog.14898
Biophysical and biochemical markers at 30-34 weeks' gestation in the prediction of adverse perinatal outcome
Valiño, N., Giunta, G., Gallo, D. M., Akolekar, R. and Nicolaides, K. H. 2016. Biophysical and biochemical markers at 30-34 weeks' gestation in the prediction of adverse perinatal outcome. Ultrasound in Obstetrics and Gynecology. 47 (2), pp. 194-202. https://doi.org/10.1002/uog.14928
Screening for trisomies by cell-free DNA testing of maternal blood: consequences of a failed result
Revello, R., Sarno, L., Ispas, A., Akolekar, R. and Nicolaides, K. H. 2016. Screening for trisomies by cell-free DNA testing of maternal blood: consequences of a failed result. Ultrasound in Obstetrics and Gynecology. 47 (6), pp. 698-704. https://doi.org/10.1002/uog.15851
Metformin versus placebo in obese pregnant women without diabetes mellitus
Syngelaki, A., Nicolaides, K. H., Balani, J., Hyer, S., Akolekar, R., Kotecha, R., Pastides, A. and Shehata, H. 2016. Metformin versus placebo in obese pregnant women without diabetes mellitus. New England Journal of Medicine. 374, pp. 434-43. https://doi.org/10.1056/NEJMoa1509819
Prospective first-trimester screening for trisomies by cell-free DNA testing of maternal blood in twin pregnancy
Sarno, L., Revello, R., Hanson, E., Akolekar, R. and Nicolaides, K. H. 2016. Prospective first-trimester screening for trisomies by cell-free DNA testing of maternal blood in twin pregnancy. Ultrasound in Obstetrics and Gynecology. 47 (6), pp. 705-11. https://doi.org/10.1002/uog.15913
Prediction of stillbirth from biochemical and biophysical markers at 11-13 weeks
Mastrodima, S., Akolekar, R., Yerlikaya, G., Tzelepis, T. and Nicolaides, K. H. 2016. Prediction of stillbirth from biochemical and biophysical markers at 11-13 weeks. Ultrasound in Obstetrics and Gynecology. 48 (5), pp. 613-617. https://doi.org/10.1002/uog.17289
Prediction of stillbirth from maternal demographic and pregnancy characteristics
Yerlikaya, G., Akolekar, R., McPherson, K., Syngelaki, A. and Nicolaides, K. H. 2016. Prediction of stillbirth from maternal demographic and pregnancy characteristics. Ultrasound in Obstetrics and Gynecology. 48 (5), pp. 607-612. https://doi.org/10.1002/uog.17290
Endoscopic placental laser coagulation in dichorionic and monochorionic triplet pregnancies
Peeva, G., Chaveeva, P., Gil Guevara, E., Akolekar, R. and Nicolaides, K. H. 2016. Endoscopic placental laser coagulation in dichorionic and monochorionic triplet pregnancies. Fetal Diagnosis and Therapy. 40 (3), pp. 174-180. https://doi.org/10.1159/000443792
Prediction of stillbirth from maternal factors, fetal biometry and uterine artery Doppler at 19-24 weeks
Akolekar, R., Tokunaka, M., Ortega, N., Syngelaki, A. and Nicolaides, K. H. 2016. Prediction of stillbirth from maternal factors, fetal biometry and uterine artery Doppler at 19-24 weeks. Ultrasound in Obstetrics and Gynecology. 48 (5), pp. 624-630. https://doi.org/10.1002/uog.17295
Prediction of stillbirth from placental growth factor at 11-13 weeks
Akolekar, R., Machuca, M., Mendes, M., Paschos, V. and Nicolaides, K. H. 2016. Prediction of stillbirth from placental growth factor at 11-13 weeks. Ultrasound in Obstetrics and Gynecology. 48 (5), pp. 618-623. https://doi.org/10.1002/uog.17288
Prediction of stillbirth from placental growth factor at 19-24 weeks
Aupont J. E., Akolekar, R., Illian, A., Neonakis, S. and Nicolaides, K. H. 2016. Prediction of stillbirth from placental growth factor at 19-24 weeks. Ultrasound in Obstetrics and Gynecology. 48 (5), pp. 631-635. https://doi.org/10.1002/uog.17229
Biophysical and biochemical markers at 35-37 weeks' gestation in the prediction of adverse perinatal outcome
Valiño, N., Giunta, G., Gallo, D. M., Akolekar, R. and Nicolaides, K. H. 2015. Biophysical and biochemical markers at 35-37 weeks' gestation in the prediction of adverse perinatal outcome. Ultrasound in Obstetrics and Gynecology. 47 (2), pp. 203-209. https://doi.org/10.1002/uog.15663