Enhancement of healing of long tubular bone defects in rabbits using a mixture of atelocollagen gel and bone marrows aspirate concentrate

Journal article

Park, H., Shetty, A., Kim, J., Kim, Y., Jang, J., Choi, N., Lee, J. and Kim, S. 2017. Enhancement of healing of long tubular bone defects in rabbits using a mixture of atelocollagen gel and bone marrows aspirate concentrate. Cells Tissues Organs. 203 (6), pp. 339-352. https://doi.org/10.1159/000455829
AuthorsPark, H., Shetty, A., Kim, J., Kim, Y., Jang, J., Choi, N., Lee, J. and Kim, S.
Abstract

We evaluated the bone-forming potential of a mixture of atelocollagen and bone marrow aspirate concentrate which
was transplanted into bone defects. Radial shaft defects of
about 10 mm in size were created in 30 New Zealand white
rabbits. Ten rabbits in the control group were not treated
further, 10 rabbits in the first experimental group (E1) received an atelocollagen injection, and 10 rabbits in the second experimental group (E2) received an injection of a mixture of atelocollagen and bone marrow aspirate concentrate.

The groups were compared radiologically at 8 weeks. Osteogenesis in group E2 progressed more rapidly than that in the other groups, and osteogenesis in group E1 progressed faster than that in the control group. Thus, the administration of a mixture of atelocollagen and bone marrow aspirate concentrate in bone defects was found to enhance bone defect healing.

KeywordsAtelocollagen; bone defect; bone marrow aspirate concentrate; delayed union; osteogenesis
Year2017
JournalCells Tissues Organs
Journal citation203 (6), pp. 339-352
PublisherKarger
ISSN1422-6405
Digital Object Identifier (DOI)https://doi.org/10.1159/000455829
Publication dates
Online17 Mar 2017
Publication process dates
Deposited20 Mar 2019
Accepted05 Jan 2017
Output statusPublished
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https://repository.canterbury.ac.uk/item/88z12/enhancement-of-healing-of-long-tubular-bone-defects-in-rabbits-using-a-mixture-of-atelocollagen-gel-and-bone-marrows-aspirate-concentrate

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