Enhancement of healing of long tubular bone defects in rabbits using a mixture of atelocollagen gel and bone marrows aspirate concentrate

Journal article


Park, H., Shetty, A., Kim, J., Kim, Y., Jang, J., Choi, N., Lee, J. and Kim, S. 2017. Enhancement of healing of long tubular bone defects in rabbits using a mixture of atelocollagen gel and bone marrows aspirate concentrate. Cells Tissues Organs. 203 (6), pp. 339-352. https://doi.org/10.1159/000455829
AuthorsPark, H., Shetty, A., Kim, J., Kim, Y., Jang, J., Choi, N., Lee, J. and Kim, S.
Abstract

We evaluated the bone-forming potential of a mixture of atelocollagen and bone marrow aspirate concentrate which
was transplanted into bone defects. Radial shaft defects of
about 10 mm in size were created in 30 New Zealand white
rabbits. Ten rabbits in the control group were not treated
further, 10 rabbits in the first experimental group (E1) received an atelocollagen injection, and 10 rabbits in the second experimental group (E2) received an injection of a mixture of atelocollagen and bone marrow aspirate concentrate.

The groups were compared radiologically at 8 weeks. Osteogenesis in group E2 progressed more rapidly than that in the other groups, and osteogenesis in group E1 progressed faster than that in the control group. Thus, the administration of a mixture of atelocollagen and bone marrow aspirate concentrate in bone defects was found to enhance bone defect healing.

KeywordsAtelocollagen; bone defect; bone marrow aspirate concentrate; delayed union; osteogenesis
Year2017
JournalCells Tissues Organs
Journal citation203 (6), pp. 339-352
PublisherKarger
ISSN1422-6405
Digital Object Identifier (DOI)https://doi.org/10.1159/000455829
Publication dates
Online17 Mar 2017
Publication process dates
Deposited20 Mar 2019
Accepted05 Jan 2017
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/88z12/enhancement-of-healing-of-long-tubular-bone-defects-in-rabbits-using-a-mixture-of-atelocollagen-gel-and-bone-marrows-aspirate-concentrate

  • 53
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Oxidized LDL accelerates cartilage destruction and inflammatory chondrocyte death in osteoarthritis by disrupting the TFEB-regulated autophagy-lysosome pathway
Lee, J., Kim, Y., Jhun, J., Na, H., Um, In Gyu, Choi, J., Woo, J., Kim, S., Shetty, A., Kim, S. and Cho, M. 2024. Oxidized LDL accelerates cartilage destruction and inflammatory chondrocyte death in osteoarthritis by disrupting the TFEB-regulated autophagy-lysosome pathway. Immune Network. 24 (3). https://doi.org/10.4110/in.2024.24.e15
Autologous collagen-induced chondrogenesis: From bench to clinical development
Chun, You Seung, Kim, Seon Ae, Kim, Yun Hwan, Lee, Joong Hoon, Shetty, Asode Ananthram and Kim, S. 2023. Autologous collagen-induced chondrogenesis: From bench to clinical development. Medicina (Kaunas, Lithuania). 59 (3), p. 530. https://doi.org/10.3390/medicina59030530
Cartilage regeneration using human umbilical cord blood derived mesenchymal stem cells: A systematic review and meta-analysis
Lee, D., Kim, Seon Ae, Song, Jun-Seob, Shetty, Asode Ananthram, Kim, Bo-Hyoung and Kim, S. 2022. Cartilage regeneration using human umbilical cord blood derived mesenchymal stem cells: A systematic review and meta-analysis. Medicina (Kaunas, Lithuania). 58 (12), p. 1801. https://doi.org/10.3390/medicina58121801
A combination of surgical and chemical induction in a rabbit model for osteoarthritis of the knee
Go, Eun Jeong, Kim, Seon Ae, Cho, Mi-La, Lee, Kwan Soo, Shetty, Asode Ananthram and Kim, S. 2022. A combination of surgical and chemical induction in a rabbit model for osteoarthritis of the knee. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-022-00488-8
Use of injectable acellular dermal matrix combined with negative pressure wound therapy in open diabetic foot amputation
Ahn, Jiyong, Park, Ho Youn, Shetty, Asode Ananthram and Hwang, Wonha 2022. Use of injectable acellular dermal matrix combined with negative pressure wound therapy in open diabetic foot amputation. Journal of Wound Care. 31 (4), pp. 310-320. https://doi.org/10.12968/jowc.2022.31.4.310
Cell therapy for osteonecrosis of femoral head and joint preservation
Chun, You Seung, Lee, Dong Hwan, Won, Tae Gu, Kim, Chan Sik, Shetty, Asode Ananthram and Kim, Seok Jung 2021. Cell therapy for osteonecrosis of femoral head and joint preservation. Journal of Clinical Orthopaedics and Trauma. 24, p. 101713. https://doi.org/10.1016/j.jcot.2021.101713
Biological reconstruction of the joint: Concepts of articular cartilage regeneration and their scientific basis
Vaish, Abhishek, Shanmugasundaram, Saseendar, Kim, Seon Ae, Lee, Dong-Hwan, Shetty, Asode Ananthram and Kim, Seok Jung 2021. Biological reconstruction of the joint: Concepts of articular cartilage regeneration and their scientific basis. Journal of Clinical Orthopaedics and Trauma. 24, p. 101718. https://doi.org/10.1016/j.jcot.2021.101718
Characterization of wild-type and STAT3 signaling-suppressed mesenchymal stem cells obtained from hemovac blood concentrates.
Lee, Dong Hwan, Kim, Seon Ae, Go, Eun Jeong, Yoon, Chi Young, Cho, Mi-La, Shetty, Asode Ananthram and Kim, Seok Jung 2021. Characterization of wild-type and STAT3 signaling-suppressed mesenchymal stem cells obtained from hemovac blood concentrates. Annals of Translational Medicine. 9 (16), p. 1284. https://doi.org/10.21037/atm-21-791
Improved healing of rabbit patellar tendon defects after an atelocollagen injection
Kim, Duck Kyu, Ahn, Jiyong, Kim, Seon Ae, Go, Eun Jeong, Lee, Dong Hwan, Park, Seung Chan, Shetty, Asode Ananthram and Kim, Seok Jung 2021. Improved healing of rabbit patellar tendon defects after an atelocollagen injection. The American Journal of Sports Medicine. 49 (11), pp. 2924-2932. https://doi.org/10.1177/03635465211030508
Comparative characterization of mesenchymal progenitor cells from osteoarthritic and rheumatoid arthritic human articular cartilage
Bm, A., Rao, S., Shetty, S., Shetty, A., Shetty, S., Kim, S. and Mohana Kumar, B. 2021. Comparative characterization of mesenchymal progenitor cells from osteoarthritic and rheumatoid arthritic human articular cartilage. Cytotherapy. 23 (5), p. S56. https://doi.org/10.1016/S1465324921003467
Preliminary results of high fibular osteotomy (HFO) and cartilage regeneration procedure for medial compartment osteoarthritis of knee with varus deformity
Jaheer, H., Shetty, A., Choi, N., Kim, K., Thirumal, S., Song, J., Kim, K., Chun, Y. and Kim, S. 2019. Preliminary results of high fibular osteotomy (HFO) and cartilage regeneration procedure for medial compartment osteoarthritis of knee with varus deformity. Regenerative Therapy. 10, pp. 112-117. https://doi.org/10.1016/j.reth.2019.02.001
A cost-effective cell- and matrix-based minimally invasive single-stage chondroregenerative technique developed with validated vertical translation methodology.
Shetty, A., Kim, S., Ahmed, S., Trattnig, S., Kim, S. and Jang, H. 2018. A cost-effective cell- and matrix-based minimally invasive single-stage chondroregenerative technique developed with validated vertical translation methodology. The Annals of the Royal College of Surgeons of England. 100 (3), pp. 240-246. https://doi.org/10.1308/rcsann.2017.0223
Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC)
Huh, S., Shetty, A., Ahmed, S., Lee, D. and Kim, S. 2016. Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC). Journal of Clinical Orthopaedics and Trauma. 7 (3), pp. 153-156. https://doi.org/10.1016/j.jcot.2016.05.004
Autologous collagen induced chondrogenesis (ACIC: Shetty-Kim technique) - A matrix based acellular single stage arthroscopic cartilage repair technique
Shetty, A., Kim, S., Shetty, V., Jang, J., Huh, S. and Lee, D. 2016. Autologous collagen induced chondrogenesis (ACIC: Shetty-Kim technique) - A matrix based acellular single stage arthroscopic cartilage repair technique. Journal of Clinical Orthopaedics and Trauma. 7 (3), pp. 164-169. https://doi.org/10.1016/j.jcot.2016.05.003