Improved healing of rabbit patellar tendon defects after an atelocollagen injection

Journal article


Kim, Duck Kyu, Ahn, Jiyong, Kim, Seon Ae, Go, Eun Jeong, Lee, Dong Hwan, Park, Seung Chan, Shetty, Asode Ananthram and Kim, Seok Jung 2021. Improved healing of rabbit patellar tendon defects after an atelocollagen injection. The American Journal of Sports Medicine. 49 (11), pp. 2924-2932. https://doi.org/10.1177/03635465211030508
AuthorsKim, Duck Kyu, Ahn, Jiyong, Kim, Seon Ae, Go, Eun Jeong, Lee, Dong Hwan, Park, Seung Chan, Shetty, Asode Ananthram and Kim, Seok Jung
AbstractPatellar tendinopathy is a common cause of limitations in daily life activities in young and/or active people. The patellar tendon consists of a complex of collagen fibers; therefore, collagen could be used as a scaffold in the treatment of patellar tendinopathy. To evaluate the healing capacity of injected atelocollagen as a treatment scaffold for patellar tendon defect and, hence, its potential for the treatment of patellar tendinopathy. Controlled laboratory study. After receiving a full-thickness patellar tendon defect, 24 New Zealand White rabbits were divided into a control group (without treatment) and an experimental group that received an atelocollagen injection into the defect. Six rabbits from each group were subsequently used for either histologic scoring or biomechanical testing. The Mann-Whitney test was used to compare histologic evaluation scores and load to failure between the 2 groups. Statistical significance was set at < .05. The experimental group showed excellent repair of the damaged patellar tendon and good remodeling of the defective area. In contrast, the control group showed defective healing with loose, irregular matrix fibers and adipose tissue formation. A statistically significant difference was found between the 2 groups in both histologic scores and biomechanical tests at postoperative week 12. Injection of atelocollagen significantly improved the regeneration of damaged patellar tendons. Atelocollagen gel injections could be used to treat patellar tendinopathy in outpatient clinic settings.
KeywordsInjection; Patellar tendon; Atelocollagen; Tendinitis; Healing enhancement
Year2021
JournalThe American Journal of Sports Medicine
Journal citation49 (11), pp. 2924-2932
PublisherSAGE Publications
ISSN1552-3365
Digital Object Identifier (DOI)https://doi.org/10.1177/03635465211030508
Official URLhttps://journals.sagepub.com/doi/abs/10.1177/03635465211030508
Publication dates
Online03 Aug 2021
Publication process dates
Deposited13 Aug 2021
Output statusPublished
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