Cell therapy for osteonecrosis of femoral head and joint preservation
Journal article
Chun, You Seung, Lee, Dong Hwan, Won, Tae Gu, Kim, Chan Sik, Shetty, Asode Ananthram and Kim, Seok Jung 2021. Cell therapy for osteonecrosis of femoral head and joint preservation. Journal of Clinical Orthopaedics and Trauma. 24, p. 101713. https://doi.org/10.1016/j.jcot.2021.101713
Authors | Chun, You Seung, Lee, Dong Hwan, Won, Tae Gu, Kim, Chan Sik, Shetty, Asode Ananthram and Kim, Seok Jung |
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Abstract | Osteonecrosis of femoral head (ONFH) is a disease of the femoral head and can cause femoral head collapse and arthritis. This can lead to pain and gait disorders. ONFH has various risk factors, it is often progressive, and if untreated results in secondary osteo-arthritis. Biological therapy makes use of bone marrow concentrate, cultured osteoblast and mesenchymal stem cell (MSC) obtained from various sources. These are often used in conjunction with core decompression surgery. In this review article, we discuss the current status of cell therapy and its limitations. We also present the future development of biological approach to treat ONFH. [Abstract copyright: © 2021.] |
Keywords | Pathogenesis; Cell therapy; Osteonecrosis; Stem cell; Core decompression; Femoral head |
Year | 2021 |
Journal | Journal of Clinical Orthopaedics and Trauma |
Journal citation | 24, p. 101713 |
Publisher | Elsevier |
ISSN | 0976-5662 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jcot.2021.101713 |
https://doi.org/S0976-5662(21)00597-X | |
Official URL | https://pubmed.ncbi.nlm.nih.gov/34926146/ |
Publication dates | |
Online | 27 Nov 2021 |
Publication process dates | |
Accepted | 19 Nov 2021 |
Deposited | 12 Jan 2022 |
Output status | Published |
Permalink -
https://repository.canterbury.ac.uk/item/8zvwx/cell-therapy-for-osteonecrosis-of-femoral-head-and-joint-preservation
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