Cell therapy for osteonecrosis of femoral head and joint preservation.

Journal article


Chun, You Seung, Lee, Dong Hwan, Won, Tae Gu, Kim, Chan Sik, Shetty, Asode Ananthram and Kim, Seok Jung 2021. Cell therapy for osteonecrosis of femoral head and joint preservation. Journal of Clinical Orthopaedics and Trauma. 24, p. 101713. https://doi.org/10.1016/j.jcot.2021.101713
AuthorsChun, You Seung, Lee, Dong Hwan, Won, Tae Gu, Kim, Chan Sik, Shetty, Asode Ananthram and Kim, Seok Jung
AbstractOsteonecrosis of femoral head (ONFH) is a disease of the femoral head and can cause femoral head collapse and arthritis. This can lead to pain and gait disorders. ONFH has various risk factors, it is often progressive, and if untreated results in secondary osteo-arthritis. Biological therapy makes use of bone marrow concentrate, cultured osteoblast and mesenchymal stem cell (MSC) obtained from various sources. These are often used in conjunction with core decompression surgery. In this review article, we discuss the current status of cell therapy and its limitations. We also present the future development of biological approach to treat ONFH. [Abstract copyright: © 2021.]
KeywordsPathogenesis; Cell therapy; Osteonecrosis; Stem cell; Core decompression; Femoral head
Year2021
JournalJournal of Clinical Orthopaedics and Trauma
Journal citation24, p. 101713
PublisherElsevier
ISSN0976-5662
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jcot.2021.101713
https://doi.org/S0976-5662(21)00597-X
Official URLhttps://pubmed.ncbi.nlm.nih.gov/34926146/
Publication dates
Online27 Nov 2021
Publication process dates
Accepted19 Nov 2021
Deposited12 Jan 2022
Output statusIn press
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