Autologous collagen induced chondrogenesis (ACIC: Shetty-Kim technique) - A matrix based acellular single stage arthroscopic cartilage repair technique

Journal article


Shetty, A., Kim, S., Shetty, V., Jang, J., Huh, S. and Lee, D. 2016. Autologous collagen induced chondrogenesis (ACIC: Shetty-Kim technique) - A matrix based acellular single stage arthroscopic cartilage repair technique. Journal of Clinical Orthopaedics and Trauma. 7 (3), pp. 164-169. https://doi.org/10.1016/j.jcot.2016.05.003
AuthorsShetty, A., Kim, S., Shetty, V., Jang, J., Huh, S. and Lee, D.
Abstract

The defects of articular cartilage in the knee joint are a common degenerative disease and currently there are several established techniques to treat this problem, each with their own advantages and shortcomings. Autologous chondrocyte implantation is the current gold standard but the technique is expensive, time-consuming and most versions require two stage procedures and an arthrotomy. Autologous collagen induced chondrogenesis (ACIC) is a single-stage arthroscopic procedure. This method uses microfracture technique with atelocollagen mixed with fibrin gel to treat articular cartilage defects. We introduce this ACIC techniques and its scientific background.

KeywordsKnee arthroscopy; Cartilage defect; Atelocollagen; ACIC; Single stage Cartilage repair
Year2016
JournalJournal of Clinical Orthopaedics and Trauma
Journal citation7 (3), pp. 164-169
PublisherElsevier
ISSN0976-5662
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jcot.2016.05.003
Publication dates
Online14 Jun 2016
Publication process dates
Deposited28 Jun 2016
Accepted10 May 2016
Output statusPublished
References

1. Widuchowski W, Widuchowski J, Trzaska T. Articular cartilage defects: study of
25,124 knee arthroscopies. Knee. 2007;14(3):177–182.
2. Hjelle K, Solheim E, Strand T, Muri R, Brittberg M. Articular cartilage defects in
1,000 knee arthroscopies. Arthroscopy. 2002;18(7):730–734.
3. Bedi A, Feeley BT, Williams III RJ. Management of articular cartilage defects of the
knee. J Bone Jt Surg Am. 2010;92(4):994–1009.
4. Knutsen G, Engebretsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation
compared with microfracture in the knee. A randomized trial. J Bone Jt Surg Am.
2004;86(3):455–464.
5. Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the
knee with autologous chondrocyte transplantation. N Engl J Med. 1994;331(14):
889–895.
6. Efe T, Theisen C, Fuchs-Winkelmann S, et al. Cell-free collagen type I matrix for
repair of cartilage defects-clinical and magnetic resonance imaging results. Knee
Surg Sports Traumatol Arthrosc. 2012;20(10):1915–1922.
7. Shetty AA, Kim SJ, Bilagi P, Stelzeneder D. Autologous collagen-induced chondrogen-
esis: single-stage arthroscopic cartilage repair technique. Orthopedics. 2013;36(5):
e648–e652.
8. Benthien JP, Behrens P. The treatment of chondral and osteochondral defects
of the knee with autologous matrix-induced chondrogenesis (AMIC): method
description and recent developments. Knee Surg Sports Traumatol Arthrosc.
2011;19(8):1316–1319.
9. Dhollander AA, De Neve F, Almqvist KF, et al. Autologous matrix-induced chondrogenesis
combined with platelet-rich plasma gel: technical description and a
five pilot patients report. Knee Surg Sports Traumatol Arthrosc. 2011;19(4):536–542.
10. de Girolamo L, Bertolini G, Cervellin M, Sozzi G, Volpi P. Treatment of chondral
defects of the knee with one step matrix-assisted technique enhanced by autolo-
gous concentrated bone marrow: in vitro characterisation of mesenchymal stem
cells from iliac crest and subchondral bone. Injury. 2010;41(11):1172–1177.
11. Benthien JP, Behrens P. Autologous matrix-induced chondrogenesis (AMIC). A onestep
procedure for retropatellar articular resurfacing. Acta Orthop Belg. 2010;76(2):
260–263.
12. Gille J, Schuseil E, Wimmer J, et al. Mid-term results of autologous matrix-induced
chondrogenesis for treatment of focal cartilage defects in the knee. Knee Surg Sports
Traumatol Arthrosc. 2010;18(11):1456–1464.
13. Kusano T, Jakob RP, Gautier E, et al. Treatment of isolated chondral and osteochondral
defects in the knee by autologous matrix-induced chondrogenesis (AMIC).
Knee Surg Sports Traumatol Arthrosc. 2012;20(10):2109–2115.
14. Roemer FW, Crema MD, Trattnig S, Guermazi A. Advances in imaging of osteoarthritis
and cartilage. Radiology. 2011;260(2):332–354.
15. Kojima KY, Demlow TA, Szumowski J, Quinn SF. Coronal fat suppression fast spin
echo images of the knee: evaluation of 202 patients with arthroscopic correlation.
Magn Reson Imaging. 1996;14(9):1017–1022.
16. Marlovits S, Striessnig G, Resinger CT, et al. Definition of pertinent parameters for
the evaluation of articular cartilage repair tissue with high-resolution magnetic
resonance imaging. Eur J Radiol. 2004;52(3):310–319.
17. Marlovits S1. Singer P, Zeller P, Mandl I, Haller J, Trattnig S. Magnetic resonance
observation of cartilage repair tissue (MOCART) for the evaluation of autologous
chondrocyte transplantation: determination of interobserver variability and correlation
to clinical outcome after 2 years. Eur J Radiol. 2006;57(1):16–23.
18. Hirai F, Beppu T, Nishimura T, et al. Carbon dioxide insufflation compared with air
insufflation in double-balloon enteroscopy: a prospective, randomized, double-
blind trial. Gastrointest Endosc. 2011;73(4):743–749.
19. Nonaka S, Saito Y, Takisawa H, et al. Safety of carbon dioxide insufflation for upper
gastrointestinal tract endoscopic treatment of patients under deep sedation. Surg
Endosc. 2010;24(7):1638–1645.
20. Dellon ES, Hawk JS, Grimm IS, Shaheen NJ. The use of carbon dioxide for insufflation
during GI endoscopy: a systematic review. Gastrointest Endosc. 2009;69(4):
843–849.
21. Corson SL, Hoffman JJ, Jackowski J, Chapman GA. Cardiopulmonary effects of direct
venous CO2 insufflation in ewes. A model for CO2 hysteroscopy. J Reprod Med.
1988;33(5):440–444.
22. Kim MK, Choi SW, Kim SR, Oh IS, Won MH. Autologous chondrocyte implantation
in the knee using fibrin. Knee Surg Sports Traumatol Arthrosc. 2010;18(4):528–534.
23. Domayer SE, Welsch GH, Nehrer S, et al. T2 mapping and dGEMRIC after autologous
chondrocyte implantation with a fibrin-based scaffold in the knee: preliminary
results. Eur J Radiol. 2010;73(3):636–642.
24. Chen H, Sun J, Hoemann CD, et al. Drilling and microfracture lead to different bone
structure and necrosis during bone-marrow stimulation for cartilage repair.
J Orthop Res. 2009;27(11):1432–1438.
25. Dhollander AA, Verdonk PC, Lambrecht S, et al. The combination of microfracture
and a cell-free polymer-based implant immersed with autologous serum for
cartilage defect coverage. Knee Surg Sports Traumatol Arthrosc. 2012;20(9):
1773–1780.
26. Krusche-Mandl I, Schmitt B, Zak L, et al. Long-term results 8 years after autologous
osteochondral transplantation: 7 T gagCEST and sodium magnetic resonance imag-
ing with morphological and clinical correlation. Osteoarthr Cartil. 2012;20(5):
357–436.

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