Injectable cultured bone marrow derived mesenchymal cells vs chondrocytes in the treatment of chondral defects of the knee - RCT with 6 years follow-up.

Journal article

Shetty, Asode Ananthram, Kim, Seok Jung, Shanmugasundaram, Saseendar, Shetty, Neha, Stelzeneder, David and Kim, Chan Sik 2022. Injectable cultured bone marrow derived mesenchymal cells vs chondrocytes in the treatment of chondral defects of the knee - RCT with 6 years follow-up. Journal of Clinical Orthopaedics and Trauma. 28, p. 101845. https://doi.org/10.1016/j.jcot.2022.101845
AuthorsShetty, Asode Ananthram, Kim, Seok Jung, Shanmugasundaram, Saseendar, Shetty, Neha, Stelzeneder, David and Kim, Chan Sik
AbstractArticular cartilage has unique biological and biomechanical characteristics. Damage to this tissue fails to heal spontaneously, leading to progressive arthritis. Cartilage repair techniques have been looked forward to in the treatment of significant cartilage injuries. Cell-based regenerative techniques like the two-staged cultured chondrocytes and single-stage mesenchymal cell transplantation have been tried with varying results and limitations. We study the outcomes of cultured bone marrow derived MSCs in the treatment of articular cartilage defects of the knee in comparison to autologous cultured chondrocyte implantation (ACI). Both cultured MSC and ACI treatment methods resulted in significant improvements in patient reported outcome measures (PROMs). There was no difference in the PROMs, MOCART scores, T2∗ mapping and dGEMRIC values between the groups. Use of cultured MSCs leads to good clinical outcomes similar to ACI and represents a promising treatment to restore the articular cartilage in the knee. [Abstract copyright: © 2022 Delhi Orthopedic Association. All rights reserved.]
Year2022
JournalJournal of Clinical Orthopaedics and Trauma
Journal citation28, p. 101845
PublisherElsevier
ISSN0976-5662
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jcot.2022.101845
https://doi.org/S0976-5662(22)00081-9
Official URLhttps://www.sciencedirect.com/science/article/pii/S0976566222000819
Publication dates
Online04 Apr 2022
Publication process dates
Accepted23 Mar 2022
Deposited05 Feb 2025
Output statusPublished
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https://repository.canterbury.ac.uk/item/9102q/injectable-cultured-bone-marrow-derived-mesenchymal-cells-vs-chondrocytes-in-the-treatment-of-chondral-defects-of-the-knee-rct-with-6-years-follow-up

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