Perspective on alternative splicing and proteome complexity in plants

Journal article

Chaudhary, S., Jabre, I., Reddy, A., Staiger, D. and Syed, N. 2019. Perspective on alternative splicing and proteome complexity in plants. Trends in Plant Science. 24 (6), pp. 496-506. https://doi.org/10.1016/j.tplants.2019.02.006
AuthorsChaudhary, S., Jabre, I., Reddy, A., Staiger, D. and Syed, N.
Abstract

Alternative splicing (AS) generates multiple transcripts from the same gene, however, AS contribution to proteome complexity remains elusive in plants. AS is prevalent under stress conditions in plants, but it is counterintuitive why plants would invest in protein synthesis under declining energy supply. We propose that plants employ AS not only to potentially increasing proteomic complexity, but also to buffer against the stress-responsive transcriptome to reduce the metabolic cost of translating all AS transcripts. To maximise efficiency under stress, plants may make fewer proteins with disordered domains via AS to diversify substrate specificity and maintain sufficient regulatory capacity. Furthermore, we suggest that chromatin state-dependent AS engenders short/long-term stress memory to mediate reproducible transcriptional response in the future.

KeywordsAlternative splicing; IDPs; protein diversity; stress memory; translational coincidence
Year2019
JournalTrends in Plant Science
Journal citation24 (6), pp. 496-506
PublisherElsevier
ISSN1360-1385
Digital Object Identifier (DOI)https://doi.org/10.1016/j.tplants.2019.02.006
Publication dates
Online06 Mar 2019
Publication process dates
Deposited02 Jul 2019
Accepted08 Mar 2019
Output statusPublished
Additional information

Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales (CC BY-NC-ND 2.0 UK)

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