Use of suboptimal sperm increases the risk of aneuploidy of the sex chromosomes in preimplantation blastocyst embryos

Journal article


Coates, A., Hesla, J., Hurliman, A., Coate, B., Holmes, E., Matthews, R., Mounts, E., Turner, K., Thornhill, A. and Griffin, D. 2015. Use of suboptimal sperm increases the risk of aneuploidy of the sex chromosomes in preimplantation blastocyst embryos. Fertility and Sterility. 104 (4), pp. 866-872. https://doi.org/10.1016/j.fertnstert.2015.06.033
AuthorsCoates, A., Hesla, J., Hurliman, A., Coate, B., Holmes, E., Matthews, R., Mounts, E., Turner, K., Thornhill, A. and Griffin, D.
Abstract

Objective

To compare autosomal and sex chromosome aneuploidy rates of embryos derived from sperm with abnormal and normal parameters.

Design

Retrospective cohort study.

Setting

Assisted reproduction center.

Patient(s)

Three thousand eight hundred thirty-five embryos generated from 629 couples undergoing IVF.

Intervention(s)

None.

Main Outcome Measure(s)

Incidence of aneuploidy in the trophectoderm of blastocyst embryos derived from standard IVF embryos and intracytoplasmic (ICSI) males with normal and oligozoospermic semen samples, in couples with donor eggs (mean maternal age, 25.0 years) and their own eggs (mean maternal age, 35.4 years).

Result(s)

The rate of sex chromosome aneuploidy was significantly (around threefold) higher in the oligozoospermic group compared with in both control groups (standard vs. ICSI insemination). This applied whether donor (young) or own (older) eggs were used. Significant differences were seen in the oligozoospermic samples for autosomes 1, 2, 11 (own eggs), and 18 (donor eggs) compared with both control groups; however, no significant difference was seen between each of the treatment groups for the overall rate of autosomal aneuploidy. No significant differences were seen between the two control groups (normozoospermic males, standard vs. ICSI insemination) in either of the egg group types for any chromosome pairs.

Conclusion(s)

Severe male factor infertility is associated with a significant increase in the occurrence of sex chromosome abnormalities in blastocyst embryos compared with in embryos derived from normal semen samples. Aneuploidy rates in embryos derived from sperm with normal parameters were not significantly different whether ICSI or standard insemination was used to achieve fertilization. These results highlight severe male factor infertility as a possible referral category for preimplantation comprehensive chromosomal screening.

Year2015
JournalFertility and Sterility
Journal citation104 (4), pp. 866-872
PublisherScience Direct
ISSN0015-0282
Digital Object Identifier (DOI)https://doi.org/10.1016/j.fertnstert.2015.06.033
Publication dates
Print11 Mar 2015
Publication process dates
Deposited30 Jun 2017
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/8836q/use-of-suboptimal-sperm-increases-the-risk-of-aneuploidy-of-the-sex-chromosomes-in-preimplantation-blastocyst-embryos

  • 53
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Morphokinetic profiling suggests that rapid first cleavage division accurately predicts the chances of blastulation in pig In vitro produced embryos
Hillyear, Lucy M., Zak, L., Beckitt, T., Griffin, D., Harvey, Simon C. and Harvey, K. 2024. Morphokinetic profiling suggests that rapid first cleavage division accurately predicts the chances of blastulation in pig In vitro produced embryos. Animals. 14 (5), p. 783. https://doi.org/10.3390/ani14050783
The role of chromosome segregation and nuclear organisation in human subfertility
Fowler, K., Mandawala, A. and Griffin, D. 2019. The role of chromosome segregation and nuclear organisation in human subfertility. Biochemical Society Transactions. 47 (1), pp. 425-432. https://doi.org/10.1042/BST20180231
The production of pig preimplantation embryos in vitro: current progress and future prospects
Fowler, K., Mandawala, A., Griffin, D., Walling, G. and Harvey, S. 2018. The production of pig preimplantation embryos in vitro: current progress and future prospects. Reproductive Biology. 18 (3), pp. 203-211. https://doi.org/10.1016/j.repbio.2018.07.001
Preterm infants have significantly longer telomeres than their term born counterparts
Vasu, V., Turner, K., George, S., Greenall, J., Slijepcevic, P. and Griffin, D. 2017. Preterm infants have significantly longer telomeres than their term born counterparts. PLoS ONE. 12 (6). https://doi.org/10.1371/journal.pone.0180082
Telomere length analysis and preterm infant health: the importance of assay design in the search for novel biomarkers
Turner, K., Vasu, V., Greenall, J. and Griffin, D. 2014. Telomere length analysis and preterm infant health: the importance of assay design in the search for novel biomarkers. Biomarkers in Medicine. 8 (4), pp. 485-498. https://doi.org/10.2217/bmm.14.13
The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans
Hall, R., Turner, K., Chaloupka, J., Cottier, F., De Sordi, L., Sanglard, D., Levin, L., Buck, J. and Mühlschlegel, F. 2011. The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryotic Cell. 10 (8), pp. 1034-1042. https://doi.org/10.1128/EC.05060-11
Upgrading short read animal genome assemblies to chromosome level using comparative genomics and a universal probe set
Damas, J., O'Connor, R., Farré, M., Lenis, V., Martell, H., Mandawala, A., Fowler, K., Joseph, S., Swain, M., Griffin, D. and Larkin, D. 2016. Upgrading short read animal genome assemblies to chromosome level using comparative genomics and a universal probe set. Genome Research.
Multicolour detection of every chromosome as a means of detecting mosaicism and nuclear organisation in human embryonic nuclei
Turner, K., Fowler, K., Fonseka, G., Griffin, D. and Ioannou, D. 2016. Multicolour detection of every chromosome as a means of detecting mosaicism and nuclear organisation in human embryonic nuclei. Panminerva Medica.
20th International Chromosome Conference (ICCXX)
Griffin, D., Fowler, K., Ellis, P. and Jackson, D. 2015. 20th International Chromosome Conference (ICCXX). Chromosome Research. https://doi.org/10.1007/s10577-014-9447-3
Reconstruction of gross avian genome structure, organization and evolution suggests that the chicken lineage most closely resembles the dinosaur avian ancestor
Romanov, M., Farré, M., Lithgow, P., Fowler, K., Skinner, B., O'Connor, R., Fonseka, G., Backström, N., Matsuda, Y., Nishida, C., Houde, P., Jarvis, E., Hanson, E., Burt, D., Larkin, D. and Griffin, D. 2014. Reconstruction of gross avian genome structure, organization and evolution suggests that the chicken lineage most closely resembles the dinosaur avian ancestor. BMC Genomics. 15 (1060). https://doi.org/10.1186/1471-2164-15-1060
Novel approach for deriving genome wide SNP analysis data from archived blood spots
Fowler, K., Reitter, C., Walling, G. and Griffin, D. 2012. Novel approach for deriving genome wide SNP analysis data from archived blood spots. BMC Research Notes. 5 (1), p. 503. https://doi.org/10.1186/1756-0500-5-503
Analyses of pig genomes provide insight into porcine demography and evolution
Groenen, M., Archibald, A., Uenishi, H., Tuggle, C., Takeuchi, Y., Rothschild, M., Rogel-Gaillard, C., Park, C., Milan, D., Megens, H., Li, S., Larkin, D., Kim, H., Frantz, L., Caccamo, M., Ahn, H., Aken, B., Anselmo, A., Anthon, C., Auvil, L., Badaoui, B., Beattie, C., Bendixen, C., Berman, D., Blecha, F., Blomberg, J., Bolund, L., Bosse, M., Botti, S., Bujie, Z., Bystrom, M., Capitanu, B., Carvalho-Silva, D., Chardon, P., Chen, C., Cheng, R., Choi, S., Chow, W., Clark, R., Clee, C., Crooijmans, R., Dawson, H., Dehais, P., De Sapio, F., Dibbits, B., Drou, N., Du, Z., Eversole, K., Fadista, J., Fairley, S., Faraut, T., Faulkner, G., Fowler, K., Fredholm, M., Fritz, E., Gilbert, J., Giuffra, E., Gorodkin, J., Griffin, D., Harrow, J., Hayward, A., Howe, K., Hu, Z., Humphray, S., Hunt, T., Hornshøj, H., Jeon, J., Jern, P., Jones, M., Jurka, J., Kanamori, H., Kapetanovic, R., Kim, J., Kim, J., Kim, K., Kim, T., Larson, G., Lee, K., Lee, K., Leggett, R., Lewin, H., Li, Y., Liu, W., Loveland, J., Lu, Y., Lunney, J., Ma, J., Madsen, O., Mann, K., Matthews, L., McLaren, S., Morozumi, T., Murtaugh, M., Narayan, J., Truong Nguyen, D., Ni, P., Oh, S., Onteru, S., Panitz, F., Park, E., Park, H., Pascal, G., Paudel, Y., Perez-Enciso, M., Ramirez-Gonzalez, R., Reecy, J., Rodriguez-Zas, S., Rohrer, G., Rund, L., Sang, Y., Schachtschneider, K., Schraiber, J., Schwartz, J., Scobie, L., Scott, C., Searle, S., Servin, B., Southey, B., Sperber, G., Stadler, P., Sweedler, J., Tafer, H., Thomsen, B., Wali, R., Wang, J., Wang, J., White, S., Xu, X., Yerle, M., Zhang, G., Zhang, J., Zhang, J., Zhao, S., Rogers, J., Churcher, C. and Schook, L. 2012. Analyses of pig genomes provide insight into porcine demography and evolution. Nature. 491 (7424), pp. 393-398. https://doi.org/10.1038/nature11622
Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis
Skinner, B., Robertson, L., Tempest, H., Langley, E., Ioannou, D., Fowler, K., Crooijmans, R., Hall, A., Griffin, D. and Völker, M. 2009. Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis. BMC Genomics. 10 (1), p. 357. https://doi.org/10.1186/1471-2164-10-357
Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds
Fowler, K., Pong-Wong, R., Bauer, J., Clemente, E., Reitter, C., Affara, N., Waite, S., Walling, G. and Griffin, D. 2013. Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds. BMC Genomics. 14 (1), p. 784. https://doi.org/10.1186/1471-2164-14-784
Identification of putative sex chromosomes in the blue tilapia, Oreochromis aureus, through synaptonemal complex and FISH analysis
Campos-Ramos, R., Harvey, S., Masabanda, J., Carrasco, L., Griffin, D., McAndrew, B., Bromage, N. and Penman, D. 2001. Identification of putative sex chromosomes in the blue tilapia, Oreochromis aureus, through synaptonemal complex and FISH analysis. Genetica. 111 (1/3), pp. 143-153. https://doi.org/10.1023/A:1013707818534
Molecular-cytogenetic analysis reveals sequence differences between the sex chromosomes of Oreochromis niloticus: evidence for an early stage of sex-chromosome differentiation
Harvey, S., Masabanda, J., Carrasco, L., Bromage, N., Penman, D. and Griffin, D. 2002. Molecular-cytogenetic analysis reveals sequence differences between the sex chromosomes of Oreochromis niloticus: evidence for an early stage of sex-chromosome differentiation. Cytogenetic and Genome Research. 97 (1-2), pp. 76-80. https://doi.org/10.1159/000064036
Karyotype evolution in tilapia: mitotic and meiotic chromosome analysis of Oreochromis Karongae and O. Niloticus × O. Karongae hybrids
Harvey, S., Campos-Ramos, R., Kennedy, D., Ezaz, M., Bromage, N., Griffin, D. and Penman, D. 2002. Karyotype evolution in tilapia: mitotic and meiotic chromosome analysis of Oreochromis Karongae and O. Niloticus × O. Karongae hybrids. Genetica. 115 (2), pp. 169-177. https://doi.org/10.1023/A:1020190918431
Early origins of the X and Y chromosomes: lessons from tilapia
Griffin, D., Harvey, S., Campos-Ramos, R., Ayling, L., Bromage, N., Masabanda, J. and Penman, D. 2002. Early origins of the X and Y chromosomes: lessons from tilapia. Cytogenetic and Genome Research. 99 (1-4), pp. 157-163. https://doi.org/10.1159/000071588
Analysis of repetitive DNA sequences in the sex chromosomes of Oreochromis niloticus
Harvey, S., Boonphakdee, C., Campos-Ramos, R., Ezaz, M., Griffin, D., Bromage, N. and Penman, D. 2003. Analysis of repetitive DNA sequences in the sex chromosomes of Oreochromis niloticus. Cytogenetic and Genome Research. 101 (3-4), pp. 314-319. https://doi.org/10.1159/000074355
Practicable approaches to facilitate rapid and accurate molecular cytogenetic mapping in birds and mammals
Morris, W., Stephenson, J., Robertson, L., Turner, K., Brown, H., Ioannou, D., Tempest, H., Skinner, B. and Griffin, D. 2007. Practicable approaches to facilitate rapid and accurate molecular cytogenetic mapping in birds and mammals. Cytogenetic and Genome Research. 117 (1-4), pp. 36-42. https://doi.org/10.1159/issn.1424-8581