Telomere length analysis and preterm infant health: the importance of assay design in the search for novel biomarkers

Journal article


Turner, K., Vasu, V., Greenall, J. and Griffin, D. 2014. Telomere length analysis and preterm infant health: the importance of assay design in the search for novel biomarkers. Biomarkers in Medicine. 8 (4), pp. 485-498. https://doi.org/10.2217/bmm.14.13
AuthorsTurner, K., Vasu, V., Greenall, J. and Griffin, D.
Abstract

Preterm infants develop an ‘aged’ phenotype in comparison with term-born infants, one component of which is adverse metabolic health and, therefore, long-term health follow-up is warranted to identify morbidity. In light of this, the identification and use of biomarkers to aid with prognosis would be a welcome Development. Telomeres are repeat sequences at the ends of each chromosome arm known to shorten as a consequence of cellular aging, and in relation to several disease conditions. The
hypothesis that expreterm infants manifest alterations in telomere attrition rate is, therefore, one of interest. Analysis of telomere length maybe a plausible technique to predict prognosis in relation to preterm birth, and early life environmental and nutritional exposures. In this article, we review the literature on telomere length analysis in the preterm infant population and examine the tools available to measure telomere length.

Year2014
JournalBiomarkers in Medicine
Journal citation8 (4), pp. 485-498
PublisherFuture Medicine
ISSN1752-0363
Digital Object Identifier (DOI)https://doi.org/10.2217/bmm.14.13
Official URLhttp://dx,doi.org/10.2217/bmm.14.13
Publication dates
PrintApr 2014
Publication process dates
Deposited23 Jun 2017
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/88365/telomere-length-analysis-and-preterm-infant-health-the-importance-of-assay-design-in-the-search-for-novel-biomarkers

  • 24
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Preterm infants have significantly longer telomeres than their term born counterparts
Vasu, V., Turner, K., George, S., Greenall, J., Slijepcevic, P. and Griffin, D. 2017. Preterm infants have significantly longer telomeres than their term born counterparts. PLoS ONE. 12 (6). https://doi.org/10.1371/journal.pone.0180082
Use of suboptimal sperm increases the risk of aneuploidy of the sex chromosomes in preimplantation blastocyst embryos
Coates, A., Hesla, J., Hurliman, A., Coate, B., Holmes, E., Matthews, R., Mounts, E., Turner, K., Thornhill, A. and Griffin, D. 2015. Use of suboptimal sperm increases the risk of aneuploidy of the sex chromosomes in preimplantation blastocyst embryos. Fertility and Sterility. 104 (4), pp. 866-872. https://doi.org/10.1016/j.fertnstert.2015.06.033
The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans
Hall, R., Turner, K., Chaloupka, J., Cottier, F., De Sordi, L., Sanglard, D., Levin, L., Buck, J. and Mühlschlegel, F. 2011. The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryotic Cell. 10 (8), pp. 1034-1042. https://doi.org/10.1128/EC.05060-11
Multicolour detection of every chromosome as a means of detecting mosaicism and nuclear organisation in human embryonic nuclei
Turner, K., Fowler, K., Fonseka, G., Griffin, D. and Ioannou, D. 2016. Multicolour detection of every chromosome as a means of detecting mosaicism and nuclear organisation in human embryonic nuclei. Panminerva Medica.
Practicable approaches to facilitate rapid and accurate molecular cytogenetic mapping in birds and mammals
Morris, W., Stephenson, J., Robertson, L., Turner, K., Brown, H., Ioannou, D., Tempest, H., Skinner, B. and Griffin, D. 2007. Practicable approaches to facilitate rapid and accurate molecular cytogenetic mapping in birds and mammals. Cytogenetic and Genome Research. 117 (1-4), pp. 36-42. https://doi.org/10.1159/issn.1424-8581