Unlocking the Role of Exercise on CD4+ T Cell Plasticity.

Journal article

Goldsmith, Chloé D, Donovan, Thomasina, Vlahovich, Nicole and Pyne, David B. 2021. Unlocking the Role of Exercise on CD4+ T Cell Plasticity. Frontiers in Immunology. 12, p. 729366. https://doi.org/10.3389/fimmu.2021.729366
AuthorsGoldsmith, Chloé D, Donovan, Thomasina, Vlahovich, Nicole and Pyne, David B.
AbstractA hallmark of T cell ageing is a loss of effector plasticity. Exercise delays T cell ageing, yet the mechanisms driving the effects of exercise on T cell biology are not well elucidated. T cell plasticity is closely linked with metabolism, and consequently sensitive to metabolic changes induced by exercise. Mitochondrial function is essential for providing the intermediate metabolites necessary to generate and modify epigenetic marks in the nucleus, thus metabolic activity and epigenetic mechanisms are intertwined. In this perspective we propose a role for exercise in CD4+ T cell plasticity, exploring links between exercise, metabolism and epigenetic reprogramming. [Abstract copyright: Copyright © 2021 Goldsmith, Donovan, Vlahovich and Pyne.]
Keywordschromatin remodeling; DNA methylation; Metabolism; Immune; Mitochondria; Histone modification; Epigenetics
Year2021
JournalFrontiers in Immunology
Journal citation12, p. 729366
PublisherFrontiers
ISSN1664-3224
Digital Object Identifier (DOI)https://doi.org/10.3389/fimmu.2021.729366
Official URLhttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.729366/full
Publication dates
Online25 Oct 2021
Publication process dates
Accepted28 Sep 2021
Deposited05 Feb 2025
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Open
Output statusPublished
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