Short-term reliability of inflammatory mediators and response to exercise in the heat.

Journal article


Guy, J., Edwards, A., Miller, C., Deakin, G. and Pyne, D. 2016. Short-term reliability of inflammatory mediators and response to exercise in the heat. Journal of Sports Sciences.
AuthorsGuy, J., Edwards, A., Miller, C., Deakin, G. and Pyne, D.
Abstract

Prospective application of serum cytokines, lipopolysaccharide (LPS), and heat shock proteins (eHSPs) requires reliable measurement of these biomarkers that can signify exercise-induced heat stress in hot conditions. To accomplish this, both short-term (7 day) reliability (at rest, n = 12) and the acute responsiveness of each biomarker to exercise in the heat (pre and post 60-min cycling, 34.5°C and 70% RH, n = 20) were evaluated. Serum was analysed for the concentration of C-reactive protein (CRP), interleukin-6 (IL-6), heat shock protein 72 (eHSP72), immunoglobulin M (IgM) and LPS. Test–retest reliability was determined as the coefficient of variation (CV). Biomarkers with the least short-term within-participant variation were IL-6 (19%, ±20%; CV, ±95% confidence limits (CL)) and LPS (23%, ±13%). Greater variability was observed for IgM, eHSP72 and CRP (CV range 28–38%). IL-6 exhibited the largest increase in response to acute exercise (95%, ±11%, P = < 0.001) and although CRP had a modest CV (12%, ±7%), it increased substantially post-exercise (P = 0.02, ES; 0.78). In contrast, eHSP72 and LPS exhibited trivial changes post-exercise. It appears variation of common inflammatory markers after exercise in the heat is not always discernible from short-term (weekly) variation.

KeywordsLipopolysaccharide; heat shock proteins; inflammatory cytokines; heat tolerance
Year2016
JournalJournal of Sports Sciences
PublisherTaylor & Francis
ISSN0264-0414
Publication dates
Online03 Sep 2016
Publication process dates
Deposited21 Aug 2018
Accepted17 Aug 2016
Accepted author manuscript
Output statusPublished
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https://repository.canterbury.ac.uk/item/88w27/short-term-reliability-of-inflammatory-mediators-and-response-to-exercise-in-the-heat

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